PLAT Proteine (PLAT)

Bezeichnung:
Plasminogen Activator, Tissue Proteine (PLAT)
Auf www.antikoerper-online.de finden Sie aktuell 72 Plasminogen Activator, Tissue (PLAT) Proteine von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PLAT Antikörper (324) und PLAT Kits (86) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 497 PLAT Produkte verfügbar.
Synonyme:
AU020998, AW212668, D8Ertd2e, PATISS, Plat, T-PA, tPA
alle Proteine anzeigen Gen GeneID UniProt
PLAT 5327 P00750
PLAT 18791 P11214
PLAT 25692 P19637

Weitere Synonyme anzeigen

PLAT Proteine (PLAT) nach Spezies

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Am meisten referenzierte PLAT Proteine

  1. Mouse (Murine) PLAT Protein expressed in Insect Cells - ABIN491605 : Lin, Jin, Mars, Reeves, Hu: Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. in The American journal of pathology 2014 (PubMed)
    Zeige alle 9 Referenzen für 491605

  2. Human PLAT Protein expressed in CHO - ABIN491596 : Harr, Moore, Chin, Chapman, Ghasabyan, Stringham, Banerjee, Silliman: Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early. in European journal of trauma and emergency surgery : official publication of the European Trauma Society 2015 (PubMed)
    Zeige alle 5 Referenzen für 491596

  3. Human PLAT Protein expressed in Human Cells - ABIN2002195 : Boose, Kuismanen, Gerard, Sambrook, Gething: The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site. in Biochemistry 1989 (PubMed)
    Zeige alle 5 Referenzen für 2002195

  4. Human PLAT Protein expressed in Insect Cells - ABIN491598 : Mantuano, Lam, Shibayama, Campana, Gonias: The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. in Journal of cell science 2015 (PubMed)
    Zeige alle 2 Referenzen für 491598

  5. Human PLAT Protein expressed in CHO - ABIN491026 : Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011 (PubMed)

Weitere Proteine zu PLAT Interaktionspartnern

Human Plasminogen Activator, Tissue (PLAT) Interaktionspartner

  1. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.

  2. Data suggest that protein aggregates interact with tissue-type plasminogen activator and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).

  3. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.

  4. tPA is a ligand of the N-terminal domain of the obligatory GluN1 (zeige GRIN1 Proteine) subunit of NMDAR (zeige GRIN1 Proteine) acting as a modulator of their dynamic distribution at the neuronal surface and subsequent signaling.

  5. t-PA binds to Lys91 in the MBP (zeige MBL2 Proteine) NH2-terminal region and PLGbinds to Lys122 in the MBP (zeige MBL2 Proteine) COOH-terminal region. This proximity promotes the activation of Pg by t-PA.

  6. local accumulation of cortisol is a causative factor for amnion epithelial apoptosis via activation of tPA/plasmin (zeige PLG Proteine) system toward the end of gestation. This may contribute to the ROM (zeige ROM1 Proteine) at both term and preterm birth.

  7. We identified a homozygous null mutation in PLAT that abrogated t-PA level in patient cells. This is the first reported human knockout mutation of PLAT. The apparent association with hydranencephaly, diaphragmatic hernia and postnatal lethality requires further validation.

  8. Tissue plasminogen activator (t-PA) antigen is a marker of cardiovascular risk. Exercise interventions associated with weight loss reduce t-PA antigen. Endurance training per se reduces t-PA antigen in healthy overweight men.

  9. we reviewed current knowledge of mechanisms by which tPA can influence brain function in physiological and pathological conditions--REVIEW}

  10. This study examines the complexes of PAI-1 (zeige SERPINE1 Proteine) with tissue-type and urokinase-type plasminogen activator (zeige PLAU Proteine) and vitronectin (zeige VTN Proteine) revealed by changes in the conformation and dynamics of the reactive center loop.

Mouse (Murine) Plasminogen Activator, Tissue (PLAT) Interaktionspartner

  1. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.

  2. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.

  3. A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA).

  4. While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis.

  5. mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA

  6. administration of ADAMTS13 (zeige ADAMTS13 Proteine) 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA (zeige RSPH1 Proteine) patency and consequently reduced cerebral infarct sizes

  7. strategies contributing to promote either endogenous production of tPA or its associated EGFR (zeige EGFR Proteine)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.

  8. Plasminogen (zeige PLG Proteine) activation contributes to wound repair and suggest that adenosine A2A receptor (zeige ADORA2A Proteine) activation promotes wound closure by a mechanism that depends on tPA.

  9. Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK (zeige PTK2 Proteine), Rac-1, and NF-kappaB (zeige NFKB1 Proteine).

  10. the protective effect of neuroserpin (zeige SERPINI1 Proteine) maybe independent from its canonical interaction with a tissue-type plasminogen activator

Pig (Porcine) Plasminogen Activator, Tissue (PLAT) Interaktionspartner

  1. The plasminogen/plasminogen (zeige PLG Proteine) activator/plasmin (zeige PLG Proteine) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.

  3. a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile

  4. ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP

Cow (Bovine) Plasminogen Activator, Tissue (PLAT) Interaktionspartner

  1. The plasminogen/plasminogen (zeige PLG Proteine) activator/plasmin (zeige PLG Proteine) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. stage-dependent regulation of granulosa cell PA and SerpinE2 (zeige SERPINE2 Proteine) production, consistent with a role in extracellular matrix remodeling during follicle growth

  3. These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (zeige MAPK8 Proteine) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.

PLAT Protein Überblick

Protein Überblick

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PLAT

  • plasminogen activator, tissue (PLAT)
  • plasminogen activator, tissue (plat)
  • tissue-type plasminogen activator (tpa)
  • plasminogen activator, tissue (Plat)
  • AU020998 Protein
  • AW212668 Protein
  • D8Ertd2e Protein
  • PATISS Protein
  • Plat Protein
  • T-PA Protein
  • tPA Protein

Bezeichner auf Proteinebene für PLAT

plasminogen activator, tissue , plasminogen activator, tissue type , tissue-type plasminogen activator , t-PA , t-plasminogen activator , tPA , tissue-type plasminogen activator-like , alteplase , reteplase , tissue plasminogen activator (t-PA) , tissue plasminogen activator , T-plasminogen activator

GENE ID SPEZIES
374183 Gallus gallus
472748 Pan troglodytes
594962 Xenopus (Silurana) tropicalis
704475 Macaca mulatta
100049466 Oryzias latipes
100050239 Equus caballus
100173068 Pongo abelii
100391990 Callithrix jacchus
100542402 Meleagris gallopavo
100586515 Nomascus leucogenys
5327 Homo sapiens
18791 Mus musculus
25692 Rattus norvegicus
397121 Sus scrofa
100725281 Cavia porcellus
100009556 Oryctolagus cuniculus
281407 Bos taurus
482840 Canis lupus familiaris
426791 Gallus gallus
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