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PLAT Proteine (PLAT)

Plasminogen Activator, Tissue Proteine (PLAT)
Auf finden Sie aktuell 70 Plasminogen Activator, Tissue (PLAT) Proteine von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PLAT Antikörper (318) und PLAT Kits (85) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 488 PLAT Produkte verfügbar.
AU020998, AW212668, D8Ertd2e, PATISS, Plat, T-PA, tPA
alle Proteine anzeigen Gen GeneID UniProt
PLAT 5327 P00750
PLAT 18791 P11214
PLAT 25692 P19637

Weitere Synonyme anzeigen

PLAT Proteine (PLAT) nach Spezies

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Am meisten referenzierte PLAT Proteine

  1. Mouse (Murine) PLAT Protein expressed in Insect Cells - ABIN491605 : Lin, Jin, Mars, Reeves, Hu: Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. in The American journal of pathology 2014 (PubMed)
    Zeige alle 9 Referenzen für ABIN491605

  2. Human PLAT Protein expressed in CHO - ABIN491596 : Harr, Moore, Chin, Chapman, Ghasabyan, Stringham, Banerjee, Silliman: Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early. in European journal of trauma and emergency surgery : official publication of the European Trauma Society 2015 (PubMed)
    Zeige alle 5 Referenzen für ABIN491596

  3. Human PLAT Protein expressed in Human Cells - ABIN2002195 : Boose, Kuismanen, Gerard, Sambrook, Gething: The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site. in Biochemistry 1989 (PubMed)
    Zeige alle 5 Referenzen für ABIN2002195

  4. Human PLAT Protein expressed in Insect Cells - ABIN491598 : Mantuano, Lam, Shibayama, Campana, Gonias: The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. in Journal of cell science 2015 (PubMed)
    Zeige alle 2 Referenzen für ABIN491598

  5. Human PLAT Protein expressed in CHO - ABIN491026 : Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011 (PubMed)

Weitere Proteine zu PLAT Interaktionspartnern

Human Plasminogen Activator, Tissue (PLAT) Interaktionspartner

  1. local accumulation of cortisol is a causative factor for amnion epithelial apoptosis via activation of tPA/plasmin (zeige PLG Proteine) system toward the end of gestation. This may contribute to the ROM (zeige ROM1 Proteine) at both term and preterm birth.

  2. We identified a homozygous null mutation in PLAT that abrogated t-PA level in patient cells. This is the first reported human knockout mutation of PLAT. The apparent association with hydranencephaly, diaphragmatic hernia and postnatal lethality requires further validation.

  3. Tissue plasminogen activator (t-PA) antigen is a marker of cardiovascular risk. Exercise interventions associated with weight loss reduce t-PA antigen. Endurance training per se reduces t-PA antigen in healthy overweight men.

  4. we reviewed current knowledge of mechanisms by which tPA can influence brain function in physiological and pathological conditions--REVIEW}

  5. This study examines the complexes of PAI-1 (zeige SERPINE1 Proteine) with tissue-type and urokinase-type plasminogen activator (zeige PLAU Proteine) and vitronectin (zeige VTN Proteine) revealed by changes in the conformation and dynamics of the reactive center loop.

  6. Data suggest that baseline levels of adiponectin, C-reactive protein, TPA, and fibrinogen or changes in these levels do not explain increased risk of diabetes type 2 in overweight women with glucose intolerance and histories of gestational diabetes.

  7. Tissue plasminogen activator (tPA) may be a general factor in the immunological response to viruses.

  8. tPA has a role in progression of periventricular white matter hyperintensities

  9. These data indicate that oxygen-glucose deprivation-triggered Cav-1 (zeige CAV1 Proteine) S-nitrosylation interacts with tPA-induced ERK (zeige EPHB2 Proteine) activation to augment MMP2 (zeige MMP2 Proteine) and 9 secretion and subsequent extracellular matrix degradation.

  10. tPA-dependent activation of EGFRs leads to downregulation of NMDAR (zeige GRIN1 Proteine) signaling and to subsequent neurotrophic effects.

Mouse (Murine) Plasminogen Activator, Tissue (PLAT) Interaktionspartner

  1. mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA

  2. administration of ADAMTS13 (zeige ADAMTS13 Proteine) 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA (zeige RSPH1 Proteine) patency and consequently reduced cerebral infarct sizes

  3. strategies contributing to promote either endogenous production of tPA or its associated EGFR (zeige EGFR Proteine)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.

  4. Plasminogen (zeige PLG Proteine) activation contributes to wound repair and suggest that adenosine A2A receptor (zeige ADORA2A Proteine) activation promotes wound closure by a mechanism that depends on tPA.

  5. Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK (zeige PTK2 Proteine), Rac-1, and NF-kappaB (zeige NFKB1 Proteine).

  6. the protective effect of neuroserpin (zeige SERPINI1 Proteine) maybe independent from its canonical interaction with a tissue-type plasminogen activator

  7. Erythropoietin (zeige EPO Proteine) protects mouse renal tubular basement membrane by promoting bone marrow cells to generate and secrete miR (zeige MLXIP Proteine)-144, which, in turn, inhibits activation of the tPA/MMP9 (zeige MMP9 Proteine)-mediated proteolytic network.

  8. tPA activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1 (zeige LYNX1 Proteine), a negative regulator of adult plasticity.

  9. Study shows that the competitive expression or activity of tPA and/or PAI-1 (zeige SERPINE1 Proteine), rather than an altered uPA (zeige PLAU Proteine) expression, determines the plasmin (zeige PLG Proteine)-mediated Abeta (zeige APP Proteine) proteolysis in brains affected by Alzheimer's disease

  10. Results demonstrate that synaptic potentiation results in tissue plasminogen activator-dependent reelin (zeige RELN Proteine) processing and suggest that extracellular proteolysis of reelin (zeige RELN Proteine) may regulate reelin (zeige RELN Proteine) signaling in the adult brain

Pig (Porcine) Plasminogen Activator, Tissue (PLAT) Interaktionspartner

  1. The plasminogen/plasminogen (zeige PLG Proteine) activator/plasmin (zeige PLG Proteine) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.

  3. a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile

  4. ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP

Cow (Bovine) Plasminogen Activator, Tissue (PLAT) Interaktionspartner

  1. The plasminogen/plasminogen (zeige PLG Proteine) activator/plasmin (zeige PLG Proteine) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. stage-dependent regulation of granulosa cell PA and SerpinE2 (zeige SERPINE2 Proteine) production, consistent with a role in extracellular matrix remodeling during follicle growth

  3. These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (zeige MAPK8 Proteine) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.

PLAT Protein Überblick

Protein Überblick

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PLAT

  • plasminogen activator, tissue (PLAT)
  • plasminogen activator, tissue (plat)
  • tissue-type plasminogen activator (tpa)
  • plasminogen activator, tissue (Plat)
  • AU020998 Protein
  • AW212668 Protein
  • D8Ertd2e Protein
  • PATISS Protein
  • Plat Protein
  • T-PA Protein
  • tPA Protein

Bezeichner auf Proteinebene für PLAT

plasminogen activator, tissue , plasminogen activator, tissue type , tissue-type plasminogen activator , t-PA , t-plasminogen activator , tPA , tissue-type plasminogen activator-like , alteplase , reteplase , tissue plasminogen activator (t-PA) , tissue plasminogen activator , T-plasminogen activator

374183 Gallus gallus
472748 Pan troglodytes
594962 Xenopus (Silurana) tropicalis
704475 Macaca mulatta
100049466 Oryzias latipes
100050239 Equus caballus
100173068 Pongo abelii
100391990 Callithrix jacchus
100542402 Meleagris gallopavo
100586515 Nomascus leucogenys
5327 Homo sapiens
18791 Mus musculus
25692 Rattus norvegicus
397121 Sus scrofa
100725281 Cavia porcellus
100009556 Oryctolagus cuniculus
281407 Bos taurus
482840 Canis lupus familiaris
426791 Gallus gallus
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