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Human GZMA ELISA Kit für Sandwich ELISA - ABIN416794
Hildebrand, Bode, Rieß, Cerny, Waldhuber, Römmler, Strack, Korten, Orth, Miethke, Heeg, Kubatzky: Granzyme A produces bioactive IL-1? through a nonapoptotic inflammasome-independent pathway. in Cell reports 2014
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this study shows that gzmA and gzmB (zeige Gzmb ELISA Kits) partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae
Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis.
The results, in susceptible B6 mice for GzmB (zeige Gzmb ELISA Kits) and in resistant 129/Sv mice for GzmA and/or the GzmB (zeige Gzmb ELISA Kits) cluster, point to granzyme-mediated host defense regulation in the liver in experimental visceral leishmaniasis.
Estrogen increases the extracellular expression and interleukin (IL)-12 (zeige IL12A ELISA Kits)-induced activity of a critical member of serine protease (zeige F2 ELISA Kits) family granzyme A.
functional divergence between human and mouse granzyme A
Regulated secretion of granzyme A and cytotoxic killing was enhanced and correlated with increased vesicle-associated membrane protein 7 (zeige VAMP7 ELISA Kits) availability.
GzmA deficiency in filarial infection is linked with reduced inflammation and a trend toward increased alternatively activated macrophages.
granzyme A- and B-cluster deficiency delays the acute progression of pneumovirus disease by reducing alveolar injury.
the genes for perforin (zeige PRF1 ELISA Kits), the three major T cell granzymes (A-C) and IFN-gamma (zeige IFNG ELISA Kits) are differentially expressed during primary activation of naive CD8 (zeige CD8A ELISA Kits)(+) T cells, kinetically and at the single-cell level
granzyme A and granzyme B (zeige Gzmb ELISA Kits) have a similar potential to induce rapid perf (zeige FABP9 ELISA Kits)-mediated apoptosis but that their individual contribution to the underlying intracellular process is dictated by the quality of the target cell
GzmA plays an unfavorable role in host defense during pneumococcal pneumonia by a mechanism that does not depend on natural killer cells.
Carbamate pesticides significantly reduced the intracellular levels of perforin (zeige PRF1 ELISA Kits), GrA (zeige NR3C1 ELISA Kits), GrB, Gr3 (zeige PRLHR ELISA Kits)/K, and GRN (zeige GRN ELISA Kits) in NK-92CI cells.
Our results suggest that granzyme A could be considered another biomarker of TB, that can be used, other than IFN-gamma (zeige IFNG ELISA Kits), to discriminate between patients with active TB and LTBI subjects
Delivered into parasite infected cells by granulysin (zeige GNLY ELISA Kits) and perforin (zeige PRF1 ELISA Kits), granzymes generate superoxide and inactivate oxidative defense enzymes to kill the parasite.
Taken together, the authors verified that histone H3 (zeige HIST3H3 ELISA Kits) is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin.
Results reveal enhanced intra- and extracellular expression of gzmA and B in patients with pulmonary TB, suggesting that gzms are part of the host response to tuberculosis.
Levels of GZMA and ITGAE (zeige ITGAE ELISA Kits) mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients.
GzmA and GzmB (zeige Gzmb ELISA Kits) expressing cells in the airways and lung parenchyma was higher in subjects who died from asthma
GZMA, GBP5 and CD64 (zeige FCGR1A ELISA Kits) genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases.
We herewith identify GZMA as critical effector molecule of human Treg function for gastrointestinal immune response in an experimental GvHD model.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.
, Granzyme A
, BLT esterase
, H factor
, Hanukah factor
, autocrine thymic lymphoma granzyme-like serine protease
, serine esterase 1
, t cell-specific serine protease 1
, CTL tryptase
, Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)
, cytotoxic T-lymphocyte proteinase 1
, h factor