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demonstration of presence of FAS and FASL in the equine corpus luteum throughout the luteal phase
IL-8 (zeige IL8 Proteine) induced apoptosis via NF-AT (zeige NFATC3 Proteine)-dependent FasL expression.
Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor (zeige AGTR2 Proteine), GATA-6 (zeige GATA6 Proteine) activation, and FasL-Fas (zeige FAS Proteine) engagement.
Results show that the FasL:Fas complex shares structural features with the FasL:DcR3 assembly and the glycosylation contributes to the activity of soluble FasL
The dysregulation of ADAM10 (zeige ADAM10 Proteine), Fas (zeige FAS Proteine) and FasL could be useful indicators of the progression and severity of OSCC.
FASLG c.-844TC genotype may be protective against familial mediterranean fever (zeige MEFV Proteine) in the Turkish population.
The rs763110 TT genotype significantly increased the risk of cervical cancer compared with the CC/CT genotype. Patients carrying this genotype presented a lower cancerous FASL expression than that of the CC/CT genotypes. OCT1 (zeige POU2F1 Proteine) was recruited to the FASL promoter region and regulated the FASL gene transcription by interacting with C/EBPbeta (zeige CEBPB Proteine).
Inhibition of miR-149-5p can induce apoptosis in THP-1 cells. These inductive effects might be via targeting FASLG and activating FADD and caspases.
FasL gene polymorphism is associated with Hashimoto's thyroiditis.
There is a positive correlation of the serum level of sFasL ( Fas (zeige FAS Proteine)/FasL axis )with uptake index of parotid gland in our expectation. In addition, liver injury involvement in SS patients showed decreased level of sFasL. Furthermore, we here also observed that the protective cytokine IL-10 (zeige IL10 Proteine) expression was positively correlated with sFasL expression
The Fas (zeige FAS Proteine)-1377G > A polymorphism is associated with a higher risk of pre-eclampsia.
It has been shown that treatment with anti-FasL prevents lymphocyte apoptosis, upregulates type-1 responses to Trypanosoma cruzi antigens, and reduces infection in macrophages cocultured with activated CD8 (zeige CD8A Proteine) T cells.
Here the authors show using an autoperfused flow chamber assay of whole blood neutrophils and intravital microscopy of the inflamed cremaster muscle that CD95 (zeige FAS Proteine) mediates leukocyte slow rolling, adhesion and transmigration upon binding of CD95-ligand (CD95L) that is presented by endothelial cells.
FasL expression in splenic CD5 (zeige CD5 Proteine)(+)CD1d (zeige CD1D Proteine)(hi) B cells was decreased compared to the control group after TLR4 (zeige TLR4 Proteine) ligation.
The interaction of Fas receptor (zeige FAS Proteine) with FasL leads to an activation of the Tag7 (zeige PGLYRP1 Proteine)-Hsp70 (zeige HSP70 Proteine) complex in the lymphocyte membrane fraction, and here FasL acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA (zeige MICA Proteine) stress ligand with the NKG2D (zeige KLRK1 Proteine) receptor is necessary for the release of this cytotoxic complex
this study shows that one-time intraocular adeno (zeige ADORA2A Proteine)-associated virus-mediated gene delivery of soluble FasL provides complete and sustained neuroprotection in the models of glaucoma
Study found that propofol anesthesia activates Fas (zeige FAS Proteine)/FasL-mediated extrinsic and Bcl-2 (zeige BCL2 Proteine)-dependent intrinsic apoptotic pathways, resulting in caspase-8 (zeige CASP8 Proteine) and caspase-9 (zeige CASP9 Proteine) activations, respectively, and established upregulation of caspase-1 (zeige CASP1 Proteine) and IL-1beta (zeige IL1B Proteine) cytokine transcriptions as well as subsequent activation of microglia. Behavioral data revealed that hyperactivity persists through adolescence and young adulthood.
this study shows that neutrophil-dependent expression of the death-receptor ligand FasL by iNKT cells restricts autoantibody production by B cells during inflammasome-driven inflammation
Expression of FasL on the surface of peripheral B-1 cells increased in filarial patients and positively correlated with peripheral apoptotic T-helper cells indicating FasL-expressing B-1 cells may be one of the important mediators of Th-cell apoptosis and immune anergy during filarial pathology.
the activation of ERK5 (zeige MAPK7 Proteine)-AKT (zeige AKT1 Proteine)-FoxO3a (zeige FOXO3 Proteine) signaling pathways by fluid shear stress resulted in a decreased expression of FasL and Bim (zeige BCL2L11 Proteine) and an inhibition of caspase-3 (zeige CASP3 Proteine) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.
these data show for the first time LRH-1 (zeige NR5A2 Proteine) expression in T cells, its role in FASLG transcription and the potential of pharmacological inhibition of LRH-1 (zeige NR5A2 Proteine) in the treatment of FasL-mediated immunopathologies
Data suggest forkhead box protein O1 (FoxO1 (zeige FOXO1 Proteine)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (zeige TNFSF10 Proteine) and Fas ligand FasL expression during follicular atresia.
FasL was not detected on fetal pig pancreatic cells but could be induced on both beta and non-beta cells when the cells were treated with IL1beta (zeige IL1B Proteine).
The expression of FAS (zeige FAS Proteine) and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported
the result indicates that the expression of FasL by chondrocytes is capable of inducing apoptosis of activated T cells
The present results may provide some insights to understand the role of Fas (zeige FAS Proteine)/FasL in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.
It was concluded that the Fas (zeige FAS Proteine)-FasL signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B (zeige TDO2 Proteine) cell lymphoma/leukemia-2 associated X upregulation.
activation of the Fas (zeige FAS Proteine) pathway and presence of FSH (zeige BRD2 Proteine) during in vitro maturation increased the incidence of apoptosis in cumulus cells
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).
, fas ligand receptor soluble form
, tumor necrosis factor receptor superfamily member 6
, Fas ligand (TNF superfamily, member 6)
, Fas (TNF receptor superfamily, member 6)
, Fas antigen
, tumor necrosis factor receptor superfamily, member 6
, tumor necrosis factor ligand superfamily member 6
, apoptosis (APO-1) antigen ligand 1
, CD95 ligand
, apoptosis antigen ligand
, fas antigen ligand
, tumor necrosis factor (ligand) superfamily, member 6
, Fas antigen ligand
, generalized lymphoproliferative disease
, Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)
, CD95L protein
, Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
, Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
, FAS antigen CD95
, APO-1 ligand
, TNF superfamily, member 6