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Nesprin3 Antikörper (Chromosome 14 Open Reading Frame 49) (AA 855-884)

Details für Produkt anti-C14orf49 Antikörper Nr. ABIN953651, Anbieter: Anmelden zum Anzeigen
Antigen
  • C14orf49
  • NET53
  • Nesp3
  • 4831426I19Rik
  • nesprin-3
Epitop
AA 855-884, C-Term
15
15
3
2
2
2
1
Reaktivität
Human, Maus
30
13
Wirt
Kaninchen
31
1
Klonalität
Polyklonal
Konjugat
Dieser Nesprin3 Antikörper ist unkonjugiert
2
2
2
2
2
2
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
29
23
14
4
3
1
1
1
1
Hersteller
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Immunogen KLH conjugated synthetic peptide between 855-884 amino acids from the C-terminal region of human SYNE3
Isotyp Ig
Spezifität This antibody reacts tp SYNE3.
Kreuzreaktivität (Details) Species reactivity (tested):Human and Mouse.
Reinigung Affinity chromatography on Protein A
Andere Bezeichnung Nesprin-3 (C14orf49 Antibody Abstract)
Hintergrund Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.Synonyms: C14orf49
Molekulargewicht 112216 Da
Gen-ID 161176
NCBI Accession NP_689805
Pathways
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Nesprin3 Antikörper (Chromosome 14 Open Reading Frame 49) (AA 855-884) (ABIN953651) SYNE3 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin ...
Western Blotting (WB) image for anti-Nesprin3 Antikörper (Chromosome 14 Open Reading Frame 49) (AA 855-884) (ABIN953651) SYNE3 Antibody (C-term) western blot analysis in mouse spleen cell line lysates (35µg...
Allgemeine Veröffentlichungen Nery, Zeng, Niland et al.: "TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton." in: Journal of cell science, Vol. 121, Issue Pt 20, pp. 3476-86, 2008 (PubMed).

Stewart-Hutchinson, Hale, Wirtz et al.: "Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness." in: Experimental cell research, Vol. 314, Issue 8, pp. 1892-905, 2008 (PubMed).

Wilhelmsen, Litjens, Kuikman et al.: "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin." in: The Journal of cell biology, Vol. 171, Issue 5, pp. 799-810, 2005 (PubMed).

Heilig, Eckenberg, Petit et al.: "The DNA sequence and analysis of human chromosome 14. ..." in: Nature, Vol. 421, Issue 6923, pp. 601-7, 2003 (PubMed).