E-cadherin Antikörper (Arg3)
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- Target Alle E-cadherin (CDH1) Antikörper anzeigen
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
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Bindungsspezifität
- Arg3
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser E-cadherin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody detects endogenous levels of ARC protein. (region surrounding Glu194)
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Mouse, Rat.
- Aufreinigung
- Affinity Chromatography using epitope-specific immunogen
- Top Product
- Discover our top product CDH1 Primärantikörper
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- Applikationshinweise
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ELISA: 1/40000-1/60000. Western blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200. Immunofluorescence: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- PBS, pH ~7.2, 0.05 % Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- Andere Bezeichnung
- ARC / .1 (CDH1 Produkte)
- Hintergrund
- Growth factor stimulation has been shown to induce the expression of immediate early genes in non-neuronal cells, which encode a variety of molecules that are potentially involved in long-term cellular responses. Similar responses induced by neurotransmitter stimulation have also been seen in neuronal cells and evidence suggests that protein synthesis is required for long-term synaptic plasticity. Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activitydependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to co-localize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.Synonyms: Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, KIAA0278
- Molekulargewicht
- approx. 24 or 28 kDa
- Gen-ID
- 23237
- NCBI Accession
- NP_056008
- UniProt
- Q7LC44
- Pathways
- WNT Signalweg, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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