anti-LKB1 (STK11) Antikörper

anti-serine/threonine Kinase 11 Antikörper (STK11)
Auf finden Sie aktuell 352 serine/threonine Kinase 11 (STK11) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen LKB1 Kits (22) und LKB1 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 413 LKB1 Produkte verfügbar.
AA408040, hLKB1, Lkb1, mLKB1, Par-4, PJS, R75140, Stk11, wu:fj61a05, xeek1, zgc:110180
Alle Antikörper anzeigen Gen GeneID UniProt
STK11 6794 Q15831
STK11 20869 Q9WTK7
STK11 314621  

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Meistgesuchte Reaktivitäten zu anti-LKB1 (STK11) Antikörper

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anti-Human LKB1 Antikörper:

anti-Mouse (Murine) LKB1 Antikörper:

anti-Rat (Rattus) LKB1 Antikörper:

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Am meisten referenzierte anti-LKB1 Antikörper

  1. Human Polyclonal LKB1 Primary Antibody für EIA, WB - ABIN359444 : Martínez-Torrecuadrada, Romero, Núñez, Alfonso, Sánchez-Céspedes, Casal: An efficient expression system for the production of functionally active human LKB1. in Journal of biotechnology 2004 (PubMed)
    Zeige alle 4 Referenzen für 359444

  2. Human Monoclonal LKB1 Primary Antibody für FACS, ELISA - ABIN969424 : Al-Nashash, Fatoo, Mirza, Ahmed, Agrawal, Thakor, All: Spinal cord injury detection and monitoring using spectral coherence. in IEEE transactions on bio-medical engineering 2009 (PubMed)
    Zeige alle 3 Referenzen für 969424

  3. Human Polyclonal LKB1 Primary Antibody für FACS, IF - ABIN391352 : Suzuki, Kusakai, Kishimoto, Shimojo, Ogura, Lavin, Esumi: IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. in Biochemical and biophysical research communications 2004 (PubMed)
    Zeige alle 3 Referenzen für 391352

  4. Human Polyclonal LKB1 Primary Antibody für IHC (p), WB - ABIN1537707 : Howard, Panchal, McCarthy, Ashworth: Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. in Genes & development 2005 (PubMed)
    Zeige alle 2 Referenzen für 1537707

  5. Human Polyclonal LKB1 Primary Antibody für IF (p), IHC (p) - ABIN751573 : Wang, Zhao, Yu, Feng, Zhang, Kou, Chu, Cui, Li, Zhang, Shen, Min: Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis. in Toxicology and applied pharmacology 2016 (PubMed)
    Zeige alle 2 Referenzen für 751573

  6. Dog (Canine) Polyclonal LKB1 Primary Antibody für IHC, WB - ABIN2776968 : Xie, Dong, Zhang, Cui, Cohen, Riek, Neumann, Schlattner, Zou: Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells. in The Journal of biological chemistry 2006 (PubMed)

  7. Human Polyclonal LKB1 Primary Antibody für FACS, IF - ABIN391350 : Sohn, Jang, Campan, Weisenberger, Dickhout, Wang, Cho, Yates, Lucock, Chiang, Austin, Choi, Laird, Kim et al.: The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer ... in International journal of cancer. Journal international du cancer 2009 (PubMed)

Weitere Antikörper gegen LKB1 Interaktionspartner

Human serine/threonine Kinase 11 (STK11) Interaktionspartner

  1. Mutations in TP53 and STK11 also impacted tumor biology regardless of KRAS status, with TP53 strongly associated with enhanced proliferation and STK11 with suppression of immune surveillance. These findings illustrate the remarkably distinct ways through which tumor suppressor mutations may contribute to heterogeneity in KRAS-mutant tumor biology.

  2. Studies indicate that the serine-threonine kinase 11 (Peutz-Jeghers syndrome) LKB1 gene is somatically mutated in female reproductive tract cancers.

  3. Our results indicate that HPV16 E6/E7 indirectly upregulated the expression of VEGF by inhibition of liver kinase B1 expression and upregulation of hypoxia-inducible factor 2alpha expression,thus propose a human papillomavirus-liver kinase B1-hypoxia-inducible factor 2A-vascular endothelial growth factor axis for the tumorigenesis of lung cancer

  4. The expression of LKB1 is down-regulated in most of the lung cell lines.

  5. Genetic variability at STK11 locus is associated with coronary artery disease risk in type 2 diabetes in the Chinese population.

  6. pregulation of PTEN (zeige PTEN Antikörper) and LKB1 in concert with negative or low levels of activated Akt (zeige AKT1 Antikörper), mTOR (zeige FRAP1 Antikörper) and S6 indicates that PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) pathway may not play a significant role in pathogenesis of leiomyoma.

  7. Data provide evidence for three novel mutations and three recurrent mutations in STK11 were identified in Chinese families with Peutz-Jeghers syndrome, which further broaden the mutation spectrum of STK11.

  8. The mutation detection rate for the LKB1 gene was 85.7% in our Chinese familial Peutz-Jeghers Syndrome and 63.2% in all Chinese Peutz-Jeghers Syndrome patients. The amplification and sequencing results of the flanking sequences presented 3 kinds of polymorphisms in introns of LKB1 gene: (c.374+24G>T, c.464+47_48inGGGGGCC, and c.920+7G>C).

  9. STK11 mutation in gastric in gastric-type endocervical adenocarcinoma is associated with worse prognosis.

  10. identification of a network linking metabolic and epigenetic alterations that is central to oncogenic transformation downstream of the liver kinase B1 (LKB1, also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and growth

Mouse (Murine) serine/threonine Kinase 11 (STK11) Interaktionspartner

  1. These results suggest that although physiologic LKB1 expression exerts a potent pro-survival effect in lymphocytes, LKB1 inactivation nonetheless facilitates transformation of B, but not T, lymphocytes.

  2. These results suggest that the LKB1-AMPK (zeige PRKAA1 Antikörper)-FoxO1 (zeige FOXO1 Antikörper) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.

  3. Lkb1 activates the Notch (zeige NOTCH1 Antikörper) signaling pathway, which subsequently increases Pax7 (zeige PAX7 Antikörper) expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 regulates Notch (zeige NOTCH1 Antikörper) activation through AMPK (zeige PRKAA1 Antikörper)-mTOR (zeige FRAP1 Antikörper) pathway in myoblasts.

  4. mitochondrial dysfunction triggers LKB1-mediated AMPK (zeige PRKAA1 Antikörper) activation, which stimulates Sirt2 (zeige SIRT2 Antikörper) phosphorylation, leading to activation of mTOR (zeige FRAP1 Antikörper)-RAPTOR (zeige RPTOR Antikörper) and Glut1 (zeige SLC2A1 Antikörper)-mediated glucose uptake.

  5. these data demonstrated that LKB1/AMPK (zeige PRKAA1 Antikörper) signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1/AMPK (zeige PRKAA1 Antikörper) signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.

  6. Data show that the serine/threonine kinase (zeige CDK4 Antikörper) LKB1 regulates mitochondrial calcium uniporter (MCU (zeige MCU Antikörper))-expression, mitochondria-dependent Ca2 (zeige CA2 Antikörper)+ clearance, and thereby, presynaptic release properties.

  7. LKB1 deficiency in LKB1(Pax2 (zeige PAX2 Antikörper)) CKO mice disrupted hair cell planar polarity during embryonic development. The results suggest that LKB1 is required in planar cell polarity formation in cochlear hair cells in mice.

  8. silencing of the LKB1 tumor suppressor affects the delamination of pre-migratory cephalic neural crest cells from the neural primordium as well as their polarization and survival, thus resulting in severe facial and brain defects

  9. LKB1 complex proteins have a role in myofilament function and myocellular "energy" sensing in the heart

  10. identification of a network linking metabolic and epigenetic alterations that is central to oncogenic transformation downstream of the liver kinase B1 (LKB1, also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and growth

Zebrafish serine/threonine Kinase 11 (STK11) Interaktionspartner

  1. inactivation of zebrafish Lkb1 upregulates pyruvate dehydrogenase kinase 2 (zeige PDK2 Antikörper) expression and inactivates pyruvate dehydrogenase (zeige PDK2 Antikörper) complex by increasing phosphorylation of pyruvate dehydrogenase (zeige PDK2 Antikörper).

  2. A critical role for LKB1 in regulating energy homeostasis at the whole-organism level in a vertebrate, is demonstrated.

  3. Data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates.

Pig (Porcine) serine/threonine Kinase 11 (STK11) Interaktionspartner

  1. Suggest that LKB1 plays an inhibitory role in endothelial cell proliferation and can promote endothelial senescence.

LKB1 (STK11) Antigen-Profil

Beschreibung des Gens

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Alternative names and synonyms associated with LKB1 (STK11)

  • serine/threonine kinase 11 (STK11) Antikörper
  • serine/threonine kinase 11 (stk11) Antikörper
  • polarization-related protein LKB1 (lkb1) Antikörper
  • serine/threonine kinase 11 (Stk11) Antikörper
  • AA408040 Antikörper
  • hLKB1 Antikörper
  • Lkb1 Antikörper
  • mLKB1 Antikörper
  • Par-4 Antikörper
  • PJS Antikörper
  • R75140 Antikörper
  • Stk11 Antikörper
  • wu:fj61a05 Antikörper
  • xeek1 Antikörper
  • zgc:110180 Antikörper

Bezeichner auf Proteinebene für STK11

serine/threonine protein kinase 11 , serine/threonine kinase 11 (Peutz-Jeghers syndrome) , GLEAN_12166 , Serine/threonine-protein kinase 11 , serine/threonine-protein kinase STK11 , serine/threonine kinase 11 , serine/threonine-protein kinase 11-like , liver kinase B1 , polarization-related protein LKB1 , renal carcinoma antigen NY-REN-19 , serine/threonine-protein kinase 11 , serine/threonine-protein kinase LKB1 , LKB1 short isoform , liver kinase B1 homolog , lkb1 , egg and embryo kinase 1 , serine/threonine-protein kinase XEEK1 , serine/threonine-protein kinase stk11

468641 Pan troglodytes
549287 Xenopus (Silurana) tropicalis
662493 Tribolium castaneum
705686 Macaca mulatta
100022246 Monodelphis domestica
100055913 Equus caballus
100460337 Pongo abelii
100477412 Ailuropoda melanoleuca
6794 Homo sapiens
20869 Mus musculus
550537 Danio rerio
399100 Xenopus laevis
420105 Gallus gallus
485088 Canis lupus familiaris
515245 Bos taurus
314621 Rattus norvegicus
100512213 Sus scrofa
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