anti-HMGCR (HMGCR) Antikörper

Bezeichnung:
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase Antikörper (HMGCR)
Auf www.antikoerper-online.de finden Sie aktuell 86 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HMGCR Kits (29) und HMGCR Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 125 HMGCR Produkte verfügbar.
Synonyme:
3H3M, BcDNA:LD15354, bro1, bs32f05.y1, CG10367, clb, Dmel\\CG10367, DmHMG-CoAr, Hmg, hmg-coa-r, HMG-CoAR, hmgc, HMGCoAr, HMGCoARr, hmgcr, HMGCR_Dm, HMGR, hmgrc, l(3)01152, l(3)04684, LDLCQ3, Red

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anti-Human HMGCR Antikörper:

anti-Rat (Rattus) HMGCR Antikörper:

anti-Mouse (Murine) HMGCR Antikörper:

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Am meisten referenzierte anti-HMGCR Antikörper

  1. Human Polyclonal HMGCR Primary Antibody für IF (p), IHC (p) - ABIN709196 : Wu, He, Wang, Xue, Ning, Zou, Ye, Li, Wang, Pang: The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 (PubMed)
    Zeige alle 4 Referenzen für 709196

  2. Human Polyclonal HMGCR Primary Antibody für ICC, IF - ABIN4319308 : Bjarnadottir, Romero, Bendahl, Jirström, Rydén, Loman, Uhlén, Johannesson, Rose, Grabau, Borgquist: Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial. in Breast cancer research and treatment 2013 (PubMed)
    Zeige alle 4 Referenzen für 4319308

Weitere Antikörper gegen HMGCR Interaktionspartner

Fruit Fly (Drosophila melanogaster) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Interaktionspartner

  1. The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos.

Human 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Interaktionspartner

  1. To estimate the association between changes in levels of LDL-C (and other lipoproteins) and the risk of cardiovascular events related to variants in the CETP (zeige CETP Antikörper) gene, both alone and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene.

  2. Low LDL cholesterol levels due to PCSK9 (zeige PCSK9 Antikörper) and HMGCR variants had no causal effect on high risk of Alzheimer's disease, vascular dementia, any dementia, or Parkinson's disease; however, low LDL cholesterol levels may have a causal effect in reducing the risk of Alzheimer's disease.

  3. These results indicate that HIF-mediated induction of Insig-2 (zeige INSIG2 Antikörper) and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  4. TGF-beta1 (zeige TGFB1 Antikörper) induces cholesterol synthesis by increasing HMG-CoA reductase mRNA expression in keratinocytes.

  5. Gene expression profile and the biological functions of HMGCR in gastric cancer were studied. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells.

  6. In this study, variants in PCSK9 (zeige PCSK9 Antikörper) had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.

  7. Data show that simvastatin significantly inhibited cellular proliferation, induced cell cycle G1 arrest and apoptosis, and caused cellular stress via reduction in the enzymatic activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR).

  8. no associations found between HMGCR rs3846662, HMRCR alternative splicing and Alzheimer's disease pathology pathology.

  9. results indicate that abnormal lipid metabolism may exist in spontaneous preterm delivery (SPTD) women and the premature fetus and the HMGCR gene may be a susceptible gene for SPTD

  10. Report the mechanism of polyphenol binding to and activity regulation of HMGR (zeige HMGA1 Antikörper) using molecular docking.

Pig (Porcine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Interaktionspartner

  1. The relative expression level of HMGR was high in liver, heart, kidney, bladder and subcutaneous fat, medium in lung, uterus and large intestine, and low in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine.

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Interaktionspartner

  1. These results indicate that HIF-mediated induction of Insig-2 (zeige INSIG2 Antikörper) and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  2. these studies designate sterol-accelerated degradation of HMGCR as a potential therapeutic target for prevention of atherosclerosis and associated cardiovascular disease.

  3. To eludicate the mechanisms underlying statin myotoxicity and HMGCR function in skeletal muscle, we developed the skeletal muscle-specific (zeige EIF3K Antikörper) HMGCR knockout mice.

  4. High-dose simvastatin inhibits HMGCoA reductase and prevents experimental hyperinflation lung injury by angioprotective and anti-inflammatory effects.

  5. TSH can regulate the phosphorylation of HMGCR via AMPK (zeige PRKAA1 Antikörper).

  6. HMGCR proteasomal-degradation by IFN strictly requires the synthesis of endogenous 25-Hydroxycholesterol.

  7. Increased cholesterol synthesis mediated by HMGCoA (zeige HMGCS2 Antikörper)-R under inflammatory stress may be one of the mechanisms for intracellular lipid accumulation and statin resistance.

  8. we consistently observe involvement of gp78 (zeige AMFR Antikörper) in Insig-1 (zeige INSIG1 Antikörper) degradation, we find no substantive evidence to support roles for either gp78 (zeige AMFR Antikörper) or TRC8 (zeige RNF139 Antikörper) in the robust sterol-accelerated degradation of HMG-CoA reductase.

  9. Hepatocyte HMGCR is essential for the survival of mice, and its abrogation elicits hepatic steatosis with jaundice and hypoglycemia.

  10. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms.

HMGCR Antigen-Profil

Beschreibung des Gens

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HMGCR

  • HMG Coenzyme A reductase (Hmgcr) Antikörper
  • 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) Antikörper
  • 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) Antikörper
  • 3-hydroxy-3-methylglutaryl-CoA reductase (hmgcr) Antikörper
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) Antikörper
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (LOC100357791) Antikörper
  • 3H3M Antikörper
  • BcDNA:LD15354 Antikörper
  • bro1 Antikörper
  • bs32f05.y1 Antikörper
  • CG10367 Antikörper
  • clb Antikörper
  • Dmel\\CG10367 Antikörper
  • DmHMG-CoAr Antikörper
  • Hmg Antikörper
  • hmg-coa-r Antikörper
  • HMG-CoAR Antikörper
  • hmgc Antikörper
  • HMGCoAr Antikörper
  • HMGCoARr Antikörper
  • hmgcr Antikörper
  • HMGCR_Dm Antikörper
  • HMGR Antikörper
  • hmgrc Antikörper
  • l(3)01152 Antikörper
  • l(3)04684 Antikörper
  • LDLCQ3 Antikörper
  • Red Antikörper

Bezeichner auf Proteinebene für HMGCR

3-Hydroxy-3-Methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase , CG10367-PA , HMG coenzyme A reductase , HMG-CoA reductase , HMGCo-A reductase , HMGCoA reductase , Hmg-CoA-reductase , Hmgcr-PA , columbus , lethal (3) 04684 , 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) , 3-hydroxy-3-methylglutaryl-Coenzyme A reductase , hydroxymethylglutaryl-CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase , 3-hydroxy-3-methylglutaryl-coenzyme A reductase , 3-hydroxy-3-methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl-CoA reductase

GENE ID SPEZIES
42803 Drosophila melanogaster
3156 Homo sapiens
479182 Canis lupus familiaris
100144446 Sus scrofa
407159 Bos taurus
25675 Rattus norvegicus
395145 Gallus gallus
397750 Xenopus laevis
100173499 Pongo abelii
15357 Mus musculus
100357791 Oryctolagus cuniculus
100756363 Cricetulus griseus
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