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Promoter of ITIH4 major acute phase protein has been isolated, cloned, and proven functional by response to an inflammatory stimulus (interleukin-6 (zeige IL6 Proteine)) in human Hep3B cells. (inter-alpha-trypsin heavy chain 4; ITIH4 (zeige ITIH4 Proteine))
Three loci showed robust, replicating association with circulating FXI (zeige F11 Proteine) levels: KNG1 (rs710446, P-value = 2.07 x 10-302), F11 (zeige F11 Proteine) (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (zeige GCKR Proteine) (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI (zeige F11 Proteine) regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin (zeige F3 Proteine) time
findings show that the KNG1 locus plays a central role as a genetic determinant of the entire coagulation pathway and thrombus/clot (zeige TXNDC17 Proteine) formation
Urinary KNG1 and RBP4 clearly respond to AKI. Additionally, RBP4 could predict recovery by monitoring this protein levels over time after AKI, as RBP4 reflects patient's normalization earlier than sCr values do.
KNG1 rs710446/ rs2304456 SNPs are not related to the incidence of Alzheimer's disease in a Hunan Han Chinese population.
Low urine KNG1 expression is associated with clear cell renal cell carcinoma (zeige MOK Proteine).
The results of this study supported the association of the epistatic interactions of ALOX5AP (zeige ALOX5AP Proteine), THBD (zeige THBD Proteine), and KNG1 and present novel evidence for the main effect of KNG1 gene on IS susceptibility.
Bradykinin stimulates pro-contractile signalling mechanisms in human myometrial cells and arrestin (zeige SAG Proteine) proteins play key roles in their regulation.
2 genetic loci (kininogen 1 and kallikrein (zeige KLK4 Proteine) B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein (zeige KLK4 Proteine)-kinin system and the RAAS.
Measuring plasma levels of cleaved HK may be a sensitive mean of assessing disease severity in HAE-C1-INH (zeige SERPING1 Proteine) patients.
The antimicrobial protein kininogen evolved adaptively in mammals and human populations.
uPAR (zeige PLAUR Proteine) mediates efferocytosis through high molecular weight kininogen interaction with phosphatidylserine on apoptotic cells
mice deficient in KNG showed less severe blood-brain barrier damage and edema formation, and the local inflammatory response was reduced compared with controls.
Domain 5 of kininogen was identified as an anti-adhesive component with a potent anti-inflammatory action in a peritonitis mouse model.
His-Gly-Lys (zeige LYZ Proteine) motif and lysine residue (Lys487) play essential roles in inhibition of cell adhesion and invasion in vitro and in prevention of metastasis of cancer cells in vivo
mKng1 is responsible for production of plasma kininogen
Bradykinin, together with its precursor and tissue kallikrein (zeige KLK1 Proteine), is continuously released into the vasculature of the isolated, perfused, lactating bovine udder.
Bradykini stimulates endothelial cell fatty acid oxidation by calmodulin-dependent kinase kinase -dependent activation of AMP-activated protein kinase (AMPK (zeige PRKAA2 Proteine))
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
, kininogen 1
, ITI heavy chain H4
, inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
, inter-alpha-inhibitor heavy chain 4
, inter-alpha-trypsin inhibitor family heavy chain-related protein
, inter-alpha-trypsin inhibitor heavy chain H4
, major acute phase protein
, alpha-2-thiol proteinase inhibitor
, fitzgerald factor
, high molecular weight kininogen
, williams-Fitzgerald-Flaujeac factor
, kininogen I
, kininogen II
, thiol proteinase inhibitor
, K-kininogen, differential splicing leads to HMW Kngk
, LMW T-kininogen I
, T-kininogen 1
, T-kininogen I
, kininogen 1, variant 1
, low molecular weight kininogen
, T-kininogen 2
, T-kininogen II
, low molecular weight (LMW) T-kininogen II
, major acute phase protein (alpha-1-MAP)