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XAF1 encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. Zusätzlich bieten wir Ihnen XAF1 Antikörper (92) und viele weitere Produktgruppen zu diesem Protein an.
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Dysfunction of XAF1 is frequent and is regulated through XAF1 promoter hypermethylation in gastric cancer. Circulating methylated XAF1 DNA was associated with tumor burden and malignant progression, which may be a valuable biomarker for diagnosis of gastric cancer, predicting patients' prognosis and monitoring tumor recurrence after surgery treatment.
XAF1 promoter hypomethylation is associated with high-grade gliomas.
human genome-wide gene expression profile assay was used to screen the targets of miR (zeige MLXIP Proteine)-3131. The overexpressed miR (zeige MLXIP Proteine)-3131 could lead to a significant decrease of DTHD1 and XAF1 mRNA level.
XAF1 acts as a feedback regulator of the TNF (zeige TNF Proteine) receptor signaling pathway to suppress NF-kappaB (zeige NFKB1 Proteine) activation
Taken together, our results suggest that ROS (zeige ROS1 Proteine) generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha (zeige GADD45A Proteine) expression by MAPK (zeige MAPK1 Proteine) and functional p53 (zeige TP53 Proteine).
Expression of XAF1 and TAp73 (zeige TP73 Proteine) was also upregulated in casticin-treated T24 cells.
Data show that X-linked inhibitor of apoptosis protein (XIAP (zeige XIAP Proteine)) mRNA and protein expression increased, whereas XIAP-associated factor 1 (XAF1) mRNA and protein expression decreased with the growth of radiation dose and exposure time.
the present study was the first to construct an adenovirus which coexpressed XAF1 and TNFalpha (zeige TNF Proteine) in the same open reading frame and expressed them proportionally. As AdXAF1&TNFalpha (zeige TNF Proteine) inhibited HCC (zeige FAM126A Proteine) cells with enhanced efficiency, it may be applicable for the treatment of HCC (zeige FAM126A Proteine).
SHC1 (zeige SHC1 Proteine) regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death.
Our study identified a novel splice variant of XAF1 in cancer cells
Interferon gamma (zeige IFNG Proteine) induces XAF1 and Noxa (zeige PMAIP1 Proteine) expression and potentiates apoptosis by STAT3 (zeige STAT3 Proteine) activation
XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1 (zeige TIE1 Proteine), Ang-1 (zeige ANGPT1 Proteine), Ang-2 (zeige ANGPT2 Proteine) and c-Myc (zeige MYC Proteine) may be mechanistically responsible for the observed antiangiogenesis effect.
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene.
XIAP-associated factor 1
, BIRC4 binding protein
, BIRC4-binding protein
, F-box protein 39
, novel TRAF-type zinc finger protein