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TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Zusätzlich bieten wir Ihnen TJP2 Antikörper (106) und TJP2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Patients with a confirmed ABCB11 (zeige ABCB11 ELISA Kits) or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (zeige ATP8B1 ELISA Kits) mutation had an elevated THBA proportion (7.51-37.26%).
Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.
Data identified two Disease-causing Genes TJP2 and GJB2 (zeige GJB2 ELISA Kits) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.
TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood
Claudin-19 (zeige CLDN19 ELISA Kits), the most abundant claudin in myelin, exhibited no binding to ZO2.
JAM-A (zeige F11R ELISA Kits) regulates epithelial permeability via association with ZO-2, afadin (zeige MLLT4 ELISA Kits), and PDZ-GEF1 (zeige RAPGEF2 ELISA Kits) to activate Rap2c (zeige RAP2C ELISA Kits) and control contraction of the apical cytoskeleton.
Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.
demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (zeige MMP14 ELISA Kits)
the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer.
ZO-2 inhibits the Wnt (zeige WNT2 ELISA Kits) signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.
Expression of Podocalyxin (zeige PODXL ELISA Kits), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (zeige EZR ELISA Kits).
SNX27 (zeige SNX27 ELISA Kits) associates with ZO-2 and modulates the epithelial tight junction.
ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway
the first PDZ domain (zeige INADL ELISA Kits) of ZO-2 interacts with YAP2 (zeige YAP1 ELISA Kits) to form complex; ZO-2 facilitates both nuclear translocation of YAP2 (zeige YAP1 ELISA Kits) & pro-apoptotic function of YAP2 (zeige YAP1 ELISA Kits); these activities of ZO-2 are PDZ-domain (zeige INADL ELISA Kits)-dependent
Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.
nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions
ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical
These findings indicate that ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 can independently determine whether and where claudins are polymerized.
These results suggest novel roles for ZO proteins as Src (zeige SRC ELISA Kits)/Csk (zeige CSK ELISA Kits) scaffolds potentially involved in the regulation of Src (zeige SRC ELISA Kits) transformation.
Early embryonic lethality of mice lacking Tjp2, but not Tjp3 (zeige TJP3 ELISA Kits), reveal critical and nonredundant roles for individual zonula occludens proteins in mammalian development.
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
Friedreich ataxia region gene X104 (tight junction protein ZO-2)
, tight junction protein ZO-2
, zona occludens 2
, zonula occludens protein 2
, tight junction protein 2 (zona occludens 2)
, Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2)
, zona occludens protein 2
, tight junction protein 2 L homeolog
, tight junction protein 2b