Tight Junction Protein 2 (Zona Occludens 2) (TJP2) ELISA Kits

TJP2 encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. Zusätzlich bieten wir Ihnen TJP2 Antikörper (106) und TJP2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
TJP2 9414 Q9UDY2
Anti-Maus TJP2 TJP2 21873 Q9Z0U1
Anti-Ratte TJP2 TJP2 115769  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 4.68 pg/mL 18.75-1200 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
Human 0.055 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 8 bis 12 Tage

Weitere ELISA Kits für TJP2 Interaktionspartner

Human Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaktionspartner

  1. Patients with a confirmed ABCB11 (zeige ABCB11 ELISA Kits) or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (zeige ATP8B1 ELISA Kits) mutation had an elevated THBA proportion (7.51-37.26%).

  2. Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors.

  3. Data identified two Disease-causing Genes TJP2 and GJB2 (zeige GJB2 ELISA Kits) in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.

  4. TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood

  5. Claudin-19 (zeige CLDN19 ELISA Kits), the most abundant claudin in myelin, exhibited no binding to ZO2.

  6. JAM-A (zeige F11R ELISA Kits) regulates epithelial permeability via association with ZO-2, afadin (zeige MLLT4 ELISA Kits), and PDZ-GEF1 (zeige RAPGEF2 ELISA Kits) to activate Rap2c (zeige RAP2C ELISA Kits) and control contraction of the apical cytoskeleton.

  7. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.

  8. demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP (zeige MMP14 ELISA Kits)

  9. the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer.

  10. ZO-2 inhibits the Wnt (zeige WNT2 ELISA Kits) signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer.

Mouse (Murine) Tight Junction Protein 2 (Zona Occludens 2) (TJP2) Interaktionspartner

  1. Expression of Podocalyxin (zeige PODXL ELISA Kits), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin (zeige EZR ELISA Kits).

  2. SNX27 (zeige SNX27 ELISA Kits) associates with ZO-2 and modulates the epithelial tight junction.

  3. ZO-2 protects against podocyte dysfunction induced by adreiamycin. This action is regulated by ZO-2-mediated inhibition of the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway

  4. the first PDZ domain (zeige INADL ELISA Kits) of ZO-2 interacts with YAP2 (zeige YAP1 ELISA Kits) to form complex; ZO-2 facilitates both nuclear translocation of YAP2 (zeige YAP1 ELISA Kits) & pro-apoptotic function of YAP2 (zeige YAP1 ELISA Kits); these activities of ZO-2 are PDZ-domain (zeige INADL ELISA Kits)-dependent

  5. Male ZO-2 chimeras show reduced fertility and pathological changes in the testis. Lanthanum tracer experiments show a compromised blood-testis barrier.

  6. nuclear ZO-2 is present in epithelial and endothelial cells, particularly in response to environmental stress conditions

  7. ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical

  8. These findings indicate that ZO-1 (zeige TJP1 ELISA Kits) and ZO-2 can independently determine whether and where claudins are polymerized.

  9. These results suggest novel roles for ZO proteins as Src (zeige SRC ELISA Kits)/Csk (zeige CSK ELISA Kits) scaffolds potentially involved in the regulation of Src (zeige SRC ELISA Kits) transformation.

  10. Early embryonic lethality of mice lacking Tjp2, but not Tjp3 (zeige TJP3 ELISA Kits), reveal critical and nonredundant roles for individual zonula occludens proteins in mammalian development.

TJP2 Antigen-Profil

Beschreibung des Gens

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit TJP2

  • tight junction protein 2 (TJP2) Antikörper
  • tight junction protein 2 (Tjp2) Antikörper
  • tight junction protein 2 L homeolog (tjp2.L) Antikörper
  • tight junction protein 2b (zona occludens 2) (tjp2b) Antikörper
  • C9DUPq21.11 Antikörper
  • DFNA51 Antikörper
  • DUP9q21.11 Antikörper
  • tjp2 Antikörper
  • wu:fb62b09 Antikörper
  • x104 Antikörper
  • zgc:92094 Antikörper
  • zo-2 Antikörper
  • zo2 Antikörper

Bezeichner auf Proteinebene für TJP2

Friedreich ataxia region gene X104 (tight junction protein ZO-2) , tight junction protein ZO-2 , zona occludens 2 , zonula occludens protein 2 , tight junction protein 2 (zona occludens 2) , Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2) , zona occludens protein 2 , tight junction protein 2 L homeolog , fb62b09 , tight junction protein 2b , tjp2.2 , zo-2.2

9414 Homo sapiens
100229218 Taeniopygia guttata
21873 Mus musculus
115769 Rattus norvegicus
395751 Gallus gallus
403854 Canis lupus familiaris
407101 Bos taurus
100729549 Cavia porcellus
779228 Xenopus laevis
436639 Danio rerio
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