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Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. Zusätzlich bieten wir Ihnen Spermine Oxidase Kits (10) und Spermine Oxidase Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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A novel enzyme with spermine oxidase properties in bovine liver mitochondria has been isolated and characterized.
AtPAO1 is the first plant Polyamine oxidase (zeige PAOX Antikörper) reported to be involved in a polyamine back-conversion pathway.
effect of Tat (zeige TAT Antikörper) on Nrf2 (zeige GABPA Antikörper) activation in human neuroblastoma (zeige ARHGEF16 Antikörper) cells and the role of NMDA receptor and spermine oxidase on Tat (zeige TAT Antikörper)-induced nuclear factor erythroid 2-related factor 2 (Nrf2 (zeige NFE2L2 Antikörper)) activation
During H. pylori infection, the enzyme spermine oxidase (SMOX) is induced, which generates hydrogen peroxide from the catabolism of the polyamine spermine, and increases gastric cancer risk.
study postulates a mechanism for SAT1 (zeige SAT1 Antikörper) and SMOX down-regulation by post-transcriptional activity of miRNAs.
Tat (zeige TAT Antikörper) was found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase (SMO)
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA (zeige S100A8 Antikörper).
each gene was associated with at least one main outcome: anxiety (SAT1 (zeige SAT1 Antikörper), SMS (zeige SMS Antikörper)), mood disorders (SAT1 (zeige SAT1 Antikörper), SMOX), and suicide attempts (SAT1 (zeige SAT1 Antikörper), OATL1 (zeige TBC1D25 Antikörper)).
Spermine oxidase (SMO) has a role in response to BENSpm and CPENSpm in breast tumor cells
Increased expression of spermine oxidase is associated with ulcerative colitis.
the genetic and epigenetic factors examined in this study show little influence on the expression level of SMOX in suicide completers.
Knockdown studies suggest that induction of SSAT (zeige SAT1 Antikörper) and SMO is correlated with the antiproliferative effects of BENSpm with 5-FU or paclitaxel in MDA-MB-231 cells.
Spermine oxidase is an important regulator of muscle gene expression and fiber size.
Data (including data from studies using recombinant mutant proteins) suggest that Glu216-Ser218 is a hot spot responsible for Smox substrate specificity; Smox with mutation E216L/S218A exhibits specificity for N'-acetylspermine rather than spermine.
ROS (zeige ROS1 Antikörper) overexposure by mSMOX delivers an earlier adaptive response to radiation
Spermine oxidase binds spermine in a similar conformation as that observed in the yeast polyamine oxidase (zeige PAOX Antikörper) FMS1-spermine complex and demonstrate a major role for residues His82 and Lys367 in substrate binding and catalysis.
expression and characterization of mouse spermine oxidase
we identified a second domain that is necessary for nuclear localization of the spermine oxidase splice variant
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.
, flavin containing amine oxidase
, flavin-containing spermine oxidase
, polyamine oxidase 1
, putative cyclin G1 interacting protein