Sirtuin 6 Proteine (SIRT6)

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 6 Antikörper (216) und Sirtuin 6 Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT6 51548 Q8N6T7
SIRT6 50721 P59941
SIRT6 299638  
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Top Sirtuin 6 Proteine auf

Showing 10 out of 21 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 11 bis 15 Tage
555,24 €
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
453,97 €
HOST_Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
685,71 €
HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
548,57 €
HOST_Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
337,56 €
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
HOST_Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
487,62 €

SIRT6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Am meisten referenzierte Sirtuin 6 Proteine

  1. Human SIRT6 Protein expressed in Escherichia coli (E. coli) - ABIN666639 : Michishita, McCord, Berber, Kioi, Padilla-Nash, Damian, Cheung, Kusumoto, Kawahara, Barrett, Chang, Bohr, Ried, Gozani, Chua: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. in Nature 2008 (PubMed)
    Zeige alle 2 Referenzen für 666639

  2. Human SIRT6 Protein expressed in Wheat germ - ABIN1320053 : Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011 (PubMed)

Weitere Proteine zu Sirtuin 6 (SIRT6) Interaktionspartnern

Human Sirtuin 6 (SIRT6) Interaktionspartner

  1. This study demonstrates that CSNK2A1 (zeige CSNK2A1 Proteine) and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1 (zeige CSNK2A1 Proteine)-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.

  2. Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.

  3. HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (zeige PARP1 Proteine) and/or Sirt6..physical interaction of HBx and PARP1 (zeige PARP1 Proteine) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis

  4. Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (zeige ATG5 Proteine), LC3B (zeige MAP1LC3B Proteine), LAMP1 (zeige LAMP1 Proteine), ABCA1 (zeige ABCA1 Proteine), ABCG1 (zeige ABCG1 Proteine), and MIRN33. (ATG5 (zeige ATG5 Proteine) = autophagy-related protein 5 (zeige CAPS Proteine); LC3B (zeige MAP1LC3B Proteine) = microtubule-associated protein 1 light chain 3 beta (zeige MAP1LC3B Proteine); LAMP1 (zeige LAMP1 Proteine) = lysosomal-associated membrane protein 1 (zeige LAMP1 Proteine); ABCA1 (zeige ABCA1 Proteine)/ABCG1 (zeige ABCG1 Proteine) = ATP-binding cassette transporters 1/8)

  5. These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (zeige HMGB1 Proteine) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.

  6. In obese patients, the expression of Sirt6 expression is reduced.

  7. positive regulator of aldose reductase (zeige AKR1B1 Proteine) expression in U937 and HeLa cells under osmotic stress

  8. these results suggest that SIRT6 enhances cell aggressiveness in PTC (zeige F9 Proteine) via BRAF (zeige BRAF Proteine)/ERK (zeige EPHB2 Proteine)/Mcl1 (zeige MCL1 Proteine) pathway, and thus may be a promising target in the treatment of the disease.

  9. our studies shed insights into the crucial functions of sirtuin 6 in esophageal carcinoma cells and provide evidence supporting sirtuin 6-based personalized therapies in esophageal carcinoma cell patients

  10. SIRT6 promotes deacetylation of a new substrate, residue K18 (zeige KRT18 Proteine) of histone H3 (zeige HIST3H3 Proteine) (H3K18), and inactivation of SIRT6 in cells leads to H3K18 hyperacetylation and aberrant accumulation of pericentric transcripts.

Cow (Bovine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (zeige MAS1 Proteine)) and management in beef cattle breeding programs.

Mouse (Murine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. These data suggest that the function of SIRT6 in the Fabp4 (zeige FABP4 Proteine)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.

  2. a physiological defects in adult SIRT6-/- mice

  3. In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.

  4. It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.

  5. Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (zeige INS Proteine) resistance in high-fat diet-fed FKO mice.

  6. SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.

  7. Data suggest that expression of Sirt6 in pancreatic beta cells protects against dysfunction (loss of hyperglycemia-induced insulin (zeige INS Proteine) secretion) and apoptosis; Sirt6 appears to protect beta cells against the oxidative stress of diabetes type 2 and of cellular aging.

  8. SIRT6, a sirtuin (zeige SIRT1 Proteine) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.

  9. data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acylase (zeige ACY1 Proteine) activity to SIRT6's various functions

  10. Sirt6 binds to promoters of NKG2D (zeige KLRK1 Proteine) ligand genes and regulates the H3K9 and H3K56 acetylation levels

Sirtuin 6 (SIRT6) Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit Sirtuin 6 Proteine (SIRT6)

  • sirtuin 6 (sirt6)
  • sirtuin 6 (SIRT6)
  • sirtuin 6 (Sirt6)
  • 2810449N18Rik Protein
  • AI043036 Protein
  • Sir2l6 Protein

Bezeichner auf Proteinebene für Sirtuin 6 Proteine (SIRT6)

sirtuin (silent mating type information regulation 2 homolog) 6 , NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6

444018 Xenopus laevis
428332 Gallus gallus
51548 Homo sapiens
485045 Canis lupus familiaris
100126274 Sus scrofa
535416 Bos taurus
50721 Mus musculus
299638 Rattus norvegicus
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