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Sirtuin 6 Proteine (SIRT6)

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 6 Antikörper (210) und Sirtuin 6 Kits (15) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT6 51548 Q8N6T7
SIRT6 50721 P59941
SIRT6 299638  
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Top Sirtuin 6 Proteine auf antikoerper-online.de

Showing 10 out of 21 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 11 bis 15 Tage
555,24 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
453,97 €
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HOST_Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
685,71 €
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HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
548,57 €
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HOST_Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
337,56 €
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HOST_Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
487,62 €
Details
HOST_Escherichia coli (E. coli) Human GST tag SIRT6 protein gel. SIRT6 run on a 10% SDS-PAGE gel and stained with Coomassie blue. Arrow indicates recombinant SIRT6. 25 μg Anmelden zum Anzeigen 1 bis 3 Tage
469,44 €
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SIRT6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Am meisten referenzierte Sirtuin 6 Proteine

  1. Human SIRT6 Protein expressed in Escherichia coli (E. coli) - ABIN666639 : Michishita, McCord, Berber, Kioi, Padilla-Nash, Damian, Cheung, Kusumoto, Kawahara, Barrett, Chang, Bohr, Ried, Gozani, Chua: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. in Nature 2008 (PubMed)
    Zeige alle 2 Referenzen für ABIN666639

  2. Human SIRT6 Protein expressed in Wheat germ - ABIN1320053 : Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011 (PubMed)

Weitere Proteine zu Sirtuin 6 (SIRT6) Interaktionspartnern

Human Sirtuin 6 (SIRT6) Interaktionspartner

  1. Data show that the increased acetylation of Ku autoantigen 70kDa (Ku70 (zeige XRCC6 Proteine)) in sirtuin 6 protein (SIRT6)-depleted cells disrupt its interaction with Bax (zeige BAX Proteine) apoptosis regulator protein (Bax (zeige BAX Proteine)), which finally resulted in Bax (zeige BAX Proteine) mitochondrial translocalization.

  2. Taken together, these data demonstrated that astragaloside IV sensitized tumor cells to gefitinib via regulation of SIRT6, suggesting that astragaloside IV may serve as potential therapeutic approach for lung cance

  3. SIRT6 prevents matrix degradation of nucleus pulposus via the NF-kappaB (zeige NFKB1 Proteine) signaling pathway in intervertebral disc degeneration. SIRT6 physically interacted with nuclear factor-kappaB (NF-kappaB (zeige NFKB1 Proteine)).

  4. The single nucleotide polymorphisms rs117385980 (C;T) in sirtuin 6 , situated 23 bases downstream of the exon 2 exon/intron border was found in heterozygous form in 1/43 longer-living healthy men (Minor allele frequency (MAF (zeige MAF Proteine)) 0,0116) and in 9/92 controls.

  5. In the model of CIA (zeige ASF1A Proteine), forced expression of SIRT6 ameliorated disease progression, osteoblastic synthesis of Cyr61 (zeige CYR61 Proteine), and macrophage recruitment. More importantly, expression of LDHA (zeige LDHA Proteine) and oxidative lesions were decreased in osteoblasts of SIRT6-treated joints. Our findings suggest that SIRT6 suppresses inflammatory response in osteoblasts via modulation of glucose metabolism and redox homeostasis.

  6. The data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acy (zeige ACY1 Proteine)lase activity to SIRT6's various functions.

  7. SIRT6, TNF-alpha (zeige TNF Proteine), and IFN-gamma (zeige IFNG Proteine) were significantly higher in lesional than perilesional and control skin.

  8. this study shoes that through the antiglycolytic activity of SIRT6, the autophagy is suppressed, which is beneficial to nasal polyp formation

  9. The promoter regions of the SIRT6 gene were genetically analyzed in large cohorts of MI patients (n = 371) and ethnically-matched controls (n = 383). Results: A total of 15 DNA sequence variants (DSVs) were identified, including seven single-nucleotide polymorphisms (SNPs). Two novel heterozygous DSVs, g.4183823G>C and g.4183742G>A, were identified in two MI patients but in none of the controls.

  10. we examined the role and mechanisms of SIRT6 in suppressing postoperative epidural scar formation. We showed that SIRT6 promoted the expression of miR (zeige MLXIP Proteine)-21 and then suppressed TGF-beta2 (zeige TGFB2 Proteine) expression in a targeted manner.

Cow (Bovine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (zeige MAS1 Proteine)) and management in beef cattle breeding programs.

Mouse (Murine) Sirtuin 6 (SIRT6) Interaktionspartner

  1. Data suggest that expression of Sirt6 in pancreatic beta cells protects against dysfunction (loss of hyperglycemia-induced insulin (zeige INS Proteine) secretion) and apoptosis; Sirt6 appears to protect beta cells against the oxidative stress of diabetes type 2 and of cellular aging.

  2. SIRT6, a sirtuin (zeige SIRT1 Proteine) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.

  3. data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acylase (zeige ACY1 Proteine) activity to SIRT6's various functions

  4. Sirt6 binds to promoters of NKG2D (zeige KLRK1 Proteine) ligand genes and regulates the H3K9 and H3K56 acetylation levels

  5. The critical role of SIRT6 on aging and inflammation.

  6. The SIRT6 regulates HSC (zeige FUT1 Proteine) homeostasis through the transcriptional repression of Wnt (zeige WNT2 Proteine) target genes. Sirt6 deletion promoted HSC (zeige FUT1 Proteine) proliferation through aberrant activation of Wnt (zeige WNT2 Proteine) signaling.

  7. Sirt6 plays a crucial role in dendritic cell differentiation and function and reduced Sirt6 activity may contribute to immunosenescence.

  8. up-regulates AMP (zeige TMPRSS5 Proteine)/ATP and then activates the AMPK (zeige PRKAA1 Proteine)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart

  9. SIRT6 is important for glucose-stimulated insulin (zeige INS Proteine) secretion from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin (zeige INS Proteine) secretion in diabetes

  10. These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.

Sirtuin 6 (SIRT6) Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit Sirtuin 6 Proteine (SIRT6)

  • sirtuin 6 (sirt6)
  • sirtuin 6 (SIRT6)
  • sirtuin 6 (Sirt6)
  • 2810449N18Rik Protein
  • AI043036 Protein
  • Sir2l6 Protein

Bezeichner auf Proteinebene für Sirtuin 6 Proteine (SIRT6)

sirtuin (silent mating type information regulation 2 homolog) 6 , NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6

GENE ID SPEZIES
444018 Xenopus laevis
428332 Gallus gallus
51548 Homo sapiens
485045 Canis lupus familiaris
100126274 Sus scrofa
535416 Bos taurus
50721 Mus musculus
299638 Rattus norvegicus
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