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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 6 Antikörper (218) und Sirtuin 6 Kits (18) und viele weitere Produktgruppen zu diesem Protein an.
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Human SIRT6 Protein expressed in Wheat germ - ABIN1320053
Palmer, Fullston, Mitchell, Setchell, Lane: SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity. in Reproduction, fertility, and development 2011
The expression of SIRT6 was reduced during cellular senescence, whereas enforced SIRT6 expression promoted cell proliferation and antagonized cellular senescence.Furthermore, SIRT6 directly interacted with p27 (zeige PAK2 Proteine). Finally, SIRT6 markedly rescued senescence induced by p27 (zeige PAK2 Proteine).
Previously unknown reciprocal influence of SIRT6 and HK2 (zeige HK2 Proteine) in regulating autophagy driven monocyte differentiation.
our findings describe TRF2 (zeige TERF2 Proteine) as a novel SIRT6 substrate and demonstrate that acetylation of TRF2 (zeige TERF2 Proteine) plays a crucial role in the regulation of TRF2 (zeige TERF2 Proteine) protein stability, thus providing a new route for modulating its expression level during oncogenesis and damage response.
SIRT6 over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 (zeige HK2 Proteine) promoter chromatin structure makes it receptive to interaction with MZF1 (zeige ZFP42 Proteine)/SIRT6 complex, thereby favouring a regulatory state conducive to diminished transcription
This study demonstrates that CSNK2A1 (zeige CSNK2A1 Proteine) and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1 (zeige CSNK2A1 Proteine)-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.
Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.
HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (zeige PARP1 Proteine) and/or Sirt6..physical interaction of HBx and PARP1 (zeige PARP1 Proteine) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis
Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (zeige ATG5 Proteine), LC3B (zeige MAP1LC3B Proteine), LAMP1 (zeige LAMP1 Proteine), ABCA1 (zeige ABCA1 Proteine), ABCG1 (zeige ABCG1 Proteine), and MIRN33. (ATG5 (zeige ATG5 Proteine) = autophagy-related protein 5 (zeige CAPS Proteine); LC3B (zeige MAP1LC3B Proteine) = microtubule-associated protein 1 light chain 3 beta (zeige MAP1LC3B Proteine); LAMP1 (zeige LAMP1 Proteine) = lysosomal-associated membrane protein 1 (zeige LAMP1 Proteine); ABCA1 (zeige ABCA1 Proteine)/ABCG1 (zeige ABCG1 Proteine) = ATP-binding cassette transporters 1/8)
These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (zeige HMGB1 Proteine) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.
In obese patients, the expression of Sirt6 expression is reduced.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (zeige MAS1 Proteine)) and management in beef cattle breeding programs.
these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function
The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (zeige INS Proteine) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.
Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.
Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (zeige NFKB1 Proteine)) and endogenous production of interleukin-6 (zeige IL6 Proteine), which led to STAT3 (zeige STAT3 Proteine) activation and the positive feedback circuits for NF-kappaB (zeige NFKB1 Proteine) stimulation; this cross talk expedited an M1 polarization
These data suggest that the function of SIRT6 in the Fabp4 (zeige FABP4 Proteine)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.
a physiological defects in adult SIRT6-/- mice
In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.
It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.
Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (zeige INS Proteine) resistance in high-fat diet-fed FKO mice.
SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6