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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 6 Antikörper (218) und Sirtuin 6 Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.
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Previously unknown reciprocal influence of SIRT6 and HK2 (zeige HK2 ELISA Kits) in regulating autophagy driven monocyte differentiation.
our findings describe TRF2 (zeige TERF2 ELISA Kits) as a novel SIRT6 substrate and demonstrate that acetylation of TRF2 (zeige TERF2 ELISA Kits) plays a crucial role in the regulation of TRF2 (zeige TERF2 ELISA Kits) protein stability, thus providing a new route for modulating its expression level during oncogenesis and damage response.
SIRT6 over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 (zeige HK2 ELISA Kits) promoter chromatin structure makes it receptive to interaction with MZF1 (zeige ZFP42 ELISA Kits)/SIRT6 complex, thereby favouring a regulatory state conducive to diminished transcription
This study demonstrates that CSNK2A1 (zeige CSNK2A1 ELISA Kits) and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1 (zeige CSNK2A1 ELISA Kits)-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.
Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.
HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (zeige PARP1 ELISA Kits) and/or Sirt6..physical interaction of HBx and PARP1 (zeige PARP1 ELISA Kits) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis
Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (zeige ATG5 ELISA Kits), LC3B (zeige MAP1LC3B ELISA Kits), LAMP1 (zeige LAMP1 ELISA Kits), ABCA1 (zeige ABCA1 ELISA Kits), ABCG1 (zeige ABCG1 ELISA Kits), and MIRN33. (ATG5 (zeige ATG5 ELISA Kits) = autophagy-related protein 5 (zeige CAPS ELISA Kits); LC3B (zeige MAP1LC3B ELISA Kits) = microtubule-associated protein 1 light chain 3 beta (zeige MAP1LC3B ELISA Kits); LAMP1 (zeige LAMP1 ELISA Kits) = lysosomal-associated membrane protein 1 (zeige LAMP1 ELISA Kits); ABCA1 (zeige ABCA1 ELISA Kits)/ABCG1 (zeige ABCG1 ELISA Kits) = ATP-binding cassette transporters 1/8)
These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (zeige HMGB1 ELISA Kits) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.
In obese patients, the expression of Sirt6 expression is reduced.
positive regulator of aldose reductase (zeige AKR1B1 ELISA Kits) expression in U937 and HeLa cells under osmotic stress
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (zeige MAS1 ELISA Kits)) and management in beef cattle breeding programs.
The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (zeige INS ELISA Kits) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.
Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.
Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (zeige NFKB1 ELISA Kits)) and endogenous production of interleukin-6 (zeige IL6 ELISA Kits), which led to STAT3 (zeige STAT3 ELISA Kits) activation and the positive feedback circuits for NF-kappaB (zeige NFKB1 ELISA Kits) stimulation; this cross talk expedited an M1 polarization
These data suggest that the function of SIRT6 in the Fabp4 (zeige FABP4 ELISA Kits)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.
a physiological defects in adult SIRT6-/- mice
In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.
It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.
Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (zeige INS ELISA Kits) resistance in high-fat diet-fed FKO mice.
SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.
Data suggest that expression of Sirt6 in pancreatic beta cells protects against dysfunction (loss of hyperglycemia-induced insulin (zeige INS ELISA Kits) secretion) and apoptosis; Sirt6 appears to protect beta cells against the oxidative stress of diabetes type 2 and of cellular aging.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6