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SESN2 encodes a member of the sestrin family of PA26-related proteins. Zusätzlich bieten wir Ihnen Sestrin 2 Antikörper (53) und Sestrin 2 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Sestrin 2 ELISA Kit für Sandwich ELISA - ABIN418510
Tsilioni, Filippidis, Kerenidi, Budanov, Zarogiannis, Gourgoulianis: Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells. in Clinical biochemistry 2016
The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma
The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4 (zeige ATF4 ELISA Kits).
Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase (zeige TXNRD1 ELISA Kits) motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1.
SESN2-AMPK (zeige PRKAA1 ELISA Kits) signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function.
Sesn2 is a potential tumor suppressor in lung epithelial cells. The expression level of Sesn2 may serve as a prognostic marker for Chinese lung cancer patients in the clinic.
The findings suggested that a decreased expression of sestrin 2 is associated with an unfavorable prognosis, which suggests that it is a novel and crucial predictor for colorectal cancer metastasis.
an AMPK (zeige PRKAA1 ELISA Kits)-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported.
GAA (zeige GAA ELISA Kits) promotes FoxO3 (zeige FOXO3 ELISA Kits) nuclear translocation and binding to the SESN2 enhancer.
Data indicate that inactivation of Sestrin 2 (Sesn2) or nuclear factor erythroid 2-related factor 2 (Nrf2 (zeige NFE2L2 ELISA Kits)) induced reactive oxygen species-mediated proteasomal inhibition and platelet-derived growth factor receptor beta (zeige PDGFRB ELISA Kits) (Pdgfrbeta) accumulation.
Sesn2 is oncogenic in skin squamous cell carcinoma and melanoma.
SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.
Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK (zeige PRKAA1 ELISA Kits) activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.
p53 (zeige TP53 ELISA Kits)-dependent coordination with SESN2 regulates AMPK (zeige PRKAA1 ELISA Kits) and mTORC1 signaling and controls parturition timing
Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin (zeige INS ELISA Kits) signaling through the activation of AMPK (zeige PRKAA1 ELISA Kits) signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin (zeige INS ELISA Kits) sensitivity and glucose metabolism via AMPK (zeige PRKAA1 ELISA Kits)-dependent autophagic activation.
Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1 (zeige HMOX1 ELISA Kits)/Sesn2 signaling pathway.
suggest that TLR-mediated Sesn2 induction is dependent on AP-1 (zeige JUN ELISA Kits), Nrf2 (zeige NFE2L2 ELISA Kits), and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity
Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (zeige PRKAA1 ELISA Kits) or TSC2 (zeige TSC2 ELISA Kits). Surprisingly, when coexpressed with a GTP (zeige AK3 ELISA Kits)-bound constitutively active form of RagB (zeige RRAGB ELISA Kits) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
Sestrin2 plays an important role in cardioprotection against I/R injury, serving as an LKB1 (zeige STK11 ELISA Kits)-AMPK (zeige PRKAA1 ELISA Kits) scaffold to initiate AMPK (zeige PRKAA1 ELISA Kits) activation during ischemic insults
Data indicate that sestrin2 expression is upregulated by dopamine D2 receptor (zeige DRD2 ELISA Kits).
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.
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