anti-SMAD, Mothers Against DPP Homolog 5 (SMAD5) Antikörper

The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. Zusätzlich bieten wir Ihnen SMAD5 Proteine (14) und SMAD5 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SMAD5 4090 Q99717
SMAD5 17129 P97454
SMAD5 59328 Q9R1V3
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Showing 10 out of 111 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-SMAD5 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate WB Suggested Anti-SMAD5 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: HepG2 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of SMAD5 expression in HeLa (A), mouse testis (B), PC12 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
Details
Human Kaninchen Unkonjugiert WB SMAD5 Antibody (Center) (ABIN1881816) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. SMAD5 Antibody (Center) (arrow) was detected using the purified Pab. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Maus Unkonjugiert ICC, FACS, IHC, ELISA, WB Figure 1: Flow cytometric analysis of Jurkat cells using SMAD5 mouse mAb (green) and negative control (purple) . Figure 2: Immunofluorescence analysis of NTERA-2 cells using SMAD5 mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
453,56 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
583,17 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-SMAD5 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti-SMAD5 antibody, IHC(P) IHC(P): Rat Intestine Tissue 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
298,57 €
Details
Human Kaninchen Unkonjugiert ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Uterus, antibody was diluted at 1:100. 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Kaninchen Unkonjugiert ICC, IF, WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using SMAD5, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2000. 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
Details
Hund Kaninchen Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
374,52 €
Details
Human Maus Unkonjugiert ELISA, FACS, ICC, IF, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
618,10 €
Details

SMAD5 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-SMAD5 Antikörper

  1. Human Polyclonal SMAD5 Primary Antibody für WB - ABIN1881816 : Park, Lee, Ahn, Kim: Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity. in Molecular bioSystems 2009 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal SMAD5 Primary Antibody für ICC, FACS - ABIN969404 : Chang, Chang, Lee, Lee, Yeh, Yeh, Cheng, Chien, Chiu: Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen SMAD5 Interaktionspartner

Zebrafish SMAD, Mothers Against DPP Homolog 5 (SMAD5) Interaktionspartner

  1. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.

  2. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.

  3. Data show that interplay of Smad1 (zeige SMAD1 Antikörper)/5 and MAP kinase (zeige MAPK1 Antikörper) signaling system (ERK (zeige MAPK1 Antikörper) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.

  4. this study uncovers that smad1 (zeige SMAD1 Antikörper) and smad9 (zeige SMAD9 Antikörper) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.

  5. Functional investigation of a subset of these genes, fgf10a (zeige FGF10 Antikörper), tgfb2 (zeige TGFB2 Antikörper), pax9 (zeige PAX9 Antikörper), and smad5 revealed their necessity in zebrafish palatogenesis.

  6. maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (zeige BMP4 Antikörper)/7 signaling to establish the initial dorsoventral asymmetry

  7. Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.

  8. that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (zeige SMAD1 Antikörper) and Smad5.

  9. Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.

Human SMAD, Mothers Against DPP Homolog 5 (SMAD5) Interaktionspartner

  1. the BMP-2 (zeige BMP2 Antikörper)/Smad1 (zeige GARS Antikörper)/5/RUNX2 (zeige RUNX2 Antikörper) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (zeige BGLAP Antikörper) synth

  2. miR (zeige MLXIP Antikörper)-23a and miR (zeige MLXIP Antikörper)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (zeige FASL Antikörper)-Fas (zeige FAS Antikörper) pathway

  3. Our findings suggest that suppression of miR (zeige MLXIP Antikörper)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (zeige RUNX2 Antikörper) signaling axis.

  4. Overexpression of the BMP4 (zeige BMP4 Antikörper)/SMAD4 (zeige SMAD4 Antikörper)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.

  5. The polycomb group protein L3MBTL1 (zeige L3MBTL1 Antikörper) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  6. adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (zeige AKT1 Antikörper) and SMAD1 (zeige GARS Antikörper)/5 during long-period culture.

  7. balance between Smad1 (zeige GARS Antikörper)/5- and Smad2 (zeige SMAD2 Antikörper)/3-dependent signaling defines the outcome of the effect of TGF-beta (zeige TGFB1 Antikörper) on atherosclerosis where Smad1 (zeige GARS Antikörper)/5 is responsible for proatherogenic effects

  8. among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs (zeige CA8 Antikörper).

  9. Our results indicated that KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4 (zeige SMAD4 Antikörper)/smad5 pathway.

  10. Inhibiting Smurf1 (zeige SMURF1 Antikörper) mediated ubiquitination of Smad1 (zeige GARS Antikörper)/5.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) Interaktionspartner

  1. We discovered that Smad1 (zeige SMAD1 Antikörper)/5/4-Amhr2 (zeige AMHR2 Antikörper)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1 (zeige SMAD1 Antikörper)/5/4-Amhr2 (zeige AMHR2 Antikörper)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.

  2. these studies characterize an accessory TGF-beta (zeige TGFB1 Antikörper)-stimulated BMP R-Smad (zeige SMAD1 Antikörper) signaling mechanism in interstitial cells of the developing lung.

  3. Thyroid-specific Smad1 (zeige SMAD1 Antikörper) and Smad5 double-knockout (Smad1 (zeige SMAD1 Antikörper)/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.

  4. Smad1 (zeige SMAD1 Antikörper) and Smad5 have overlapping functions to govern hepcidin (zeige HAMP Antikörper) transcription. Moreover, erythropoietin (zeige EPO Antikörper) and erythroferrone target Smad1 (zeige SMAD1 Antikörper)/5 signaling and require Smad1 (zeige SMAD1 Antikörper)/5 to suppress hepcidin (zeige HAMP Antikörper) expression.

  5. miR (zeige MLXIP Antikörper)-106b-5p and miR-17-5p are novel Smad5 regulators.

  6. BetA can enhance in vivo osteogenic potentials of BMP2 (zeige BMP2 Antikörper), possibly via stimulating Smad 1 (zeige SMAD1 Antikörper)/5/8 and p38 (zeige CRK Antikörper) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.

  7. Data show that in R-Smad (zeige SMAD1 Antikörper) proteins Smad1 (zeige SMAD1 Antikörper);Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD (zeige SMAD1 Antikörper) signaling is dispensable for self-renewal.

  8. Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).

  9. The crystal structure of Smad5-MH1 (zeige SCN5A Antikörper) domain in complex with a composite DNA sequence demonstrates that the MH1 (zeige SCN5A Antikörper) domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 (zeige SCN5A Antikörper) assembly.

  10. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (zeige BMP2 Antikörper)/Smad1 (zeige SMAD1 Antikörper)/5/8 and Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathways.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) Interaktionspartner

  1. a detailed computational model for TGF-beta (zeige TGFB1 Antikörper) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Antikörper)/5/8 and Smad2 (zeige SMAD2 Antikörper)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Antikörper).

SMAD5 Antigen-Profil

Protein Überblick

The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Genbezeichner und Symbole assoziert mit SMAD5

  • SMAD family member 5 (SMAD5) Antikörper
  • MAD homolog 5 (Drosophila) (smad5) Antikörper
  • SMAD family member 4, gene 2 (smad4.2-b) Antikörper
  • SMAD family member 5 (Smad5) Antikörper
  • 1110051M15Rik Antikörper
  • AI451355 Antikörper
  • DKFZp468M0619 Antikörper
  • dpc4 Antikörper
  • Dwf-C Antikörper
  • DWFC Antikörper
  • fb67b04 Antikörper
  • jip Antikörper
  • JV5-1 Antikörper
  • mad Antikörper
  • madh4 Antikörper
  • Madh5 Antikörper
  • MusMLP Antikörper
  • sb:cb400 Antikörper
  • SBN Antikörper
  • SMAD5 Antikörper
  • smad10 Antikörper
  • smd5 Antikörper
  • wu:fb67b04 Antikörper
  • xsmad4 Antikörper
  • XSmad4alpha Antikörper

Bezeichner auf Proteinebene für SMAD5

mothers against decapentaplegic homolog 5 , SMA- and MAD-related protein 5 , SMAD 5 , SMAD family member 5 , mothers against DPP homolog 5 , pgy , piggytail , somitabun , MAD, mothers against decapentaplegic homolog 5 , SMAD, mothers against DPP homolog 5 , mothers against decapentaplegic, drosophila, homolog of, 5 , MAD homolog 5 , Smad 5 , dwarfin-C , mSmad5 , Mothers against decapentaplegic homolog 5

GENE ID SPEZIES
100033851 Equus caballus
30641 Danio rerio
403398 Xenopus laevis
4090 Homo sapiens
17129 Mus musculus
59328 Rattus norvegicus
395679 Gallus gallus
481520 Canis lupus familiaris
768050 Bos taurus
100173534 Pongo abelii
100303615 Sus scrofa
Ausgewählte Anbieter für anti-SMAD5 (SMAD5) Antikörper
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