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This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. Zusätzlich bieten wir Ihnen SRGAP2 Antikörper (26) und SRGAP2 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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The extended F-BAR (F-BARx) domain of SRGAP2 generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.
human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance
This study illustrated that the role of SRGAP2 protein and its human-specific paralogs in human brain development and evolution.
interlocus gene conversions in SRGAP2
SRGAP2 has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp (zeige MBL2 ELISA Kits) of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.
Results uncover a new function for ancestral SRGAP2 in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex
after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.
srGAP2 arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.
FNBP2 gene was linked to IKBKE (zeige IKBKE ELISA Kits) and NORE1 (zeige RASSF5 ELISA Kits) genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma.
The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (zeige ARHGEF16 ELISA Kits) cells.
Data show that srGAP2 is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.
Study reports that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.
SLIT-ROBO Rho GTPase-activating protein 2
, formin binding protein 2
, formin-binding protein 2
, rho GTPase-activating protein 34
, formin-binding protein 27