anti-Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) Antikörper

The product of P2RY12 belongs to the family of G-protein coupled receptors. Zusätzlich bieten wir Ihnen P2RY12 Kits (24) und P2RY12 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
P2RY12 70839 Q9CPV9
P2RY12 64805 Q9H244
P2RY12 64803 Q9EPX4
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Top anti-P2RY12 Antikörper auf antikoerper-online.de

Showing 10 out of 34 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert DB, ELISA, ICC, IF, IHC, IHC (p), IP, WB Western Blot: P2Y12/P2RY12 Antibody [NBP1-78249] - Antibody dilution 1:500, MW is 41 kDa Immunohistochemistry-Paraffin: P2Y12/P2RY12 Antibody [NBP1-78249] - Rat spinal cord. Dilution 1:100. 0.1 mg Anmelden zum Anzeigen 10 bis 13 Tage
$725.94
Details
Human Kaninchen Biotin IHC (p), WB   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$395.45
Details
Human Kaninchen Unkonjugiert IHC (p), WB Formalin-fixed and paraffin embedded rat anterior horn of spinal cord labeled with Anti-P2Y12 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$318.45
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: P2Y12 Antibody [NBP1-89673] - Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in reaction center cells, lymphoid cells outside reaction centra. Western Blot: P2Y12 Antibody [NBP1-89673] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert WB P2RY12 antibody used at 1 ug/ml to detect target protein. 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$473.93
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Human Kaninchen HRP IHC (p), WB   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$417.45
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Kaninchen Unkonjugiert ICC, IHC (p) Anti-P2RY12 / P2Y12 antibody  ABIN1049207 IHC staining of human blood, platelets. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Hund Kaninchen Unkonjugiert IHC (p) Anti-P2RY12 / P2Y12 antibody  ABIN1049208 IHC staining of human bone marrow, megakaryocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Human Kaninchen Unkonjugiert WB Western Blot: P2Y12 Antibody [NBP2-19660] - Sample (30 ug of whole cell lysate) A: NT2D1 B: PC-3 C: U87-MG D: SK-N-SH 10% SDS PAGE gel, diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details

P2RY12 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine)


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Rat (Rattus)


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Am meisten referenzierte anti-P2RY12 Antikörper

  1. Human Polyclonal P2RY12 Primary Antibody für IHC (p), WB - ABIN1394995 : Garcia-Mesa, Jay, Checkley, Luttge, Dobrowolski, Valadkhan, Landreth, Karn, Alvarez-Carbonell: Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system. in Journal of neurovirology 2016 (PubMed)

  2. Human Polyclonal P2RY12 Primary Antibody für DB, ELISA - ABIN4342653 : Abbracchio, Burnstock: Purinoceptors: are there families of P2X and P2Y purinoceptors? in Pharmacology & therapeutics 1995 (PubMed)

  3. Human Polyclonal P2RY12 Primary Antibody für IHC, IHC (p) - ABIN4342655 : Bornø, Ploug, Bune, Rosenmeier, Thaning: Purinergic receptors expressed in human skeletal muscle fibres. in Purinergic signalling 2012 (PubMed)

Weitere Antikörper gegen P2RY12 Interaktionspartner

Mouse (Murine) Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) Interaktionspartner

  1. Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/P2Y13 (zeige P2RY13 Antikörper) receptors among BV-2 microglia.

  2. findings not only revealed the critical role of P2Y12 in Th17 differentiation and EAE pathogenesis, but also suggested the promising potential of P2Y12 antagonists in the treatment of autoimmune diseases

  3. P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice.

  4. In P2Y12(-/-) mice, the growth of syngeneic ovarian cancer tumors was reduced by >85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1 (zeige P2RY1 Antikörper)(-/-) and WT mice.

  5. Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin (zeige CFL1 Antikörper) dephosphorylation, plays a critical role in the development of atherosclerotic lesions.

  6. P2Y12 null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y12 receptor during sepsis.

  7. excessive mechanical stress may induce a sustained release of ADP and promote SMC senescence via P2ry12-dependent sustained Ras activation, thereby contributing to excessive inflammation and degeneration, which provides insights into TAAD formation and progression.

  8. AHR (zeige AHR Antikörper) and airway inflammation in a mouse model of asthma. P2Y12 can be a novel therapeutic target to the suppression of eosinophils in asthma.

  9. quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury

  10. Disrupting P2Y12 alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity.

Human Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) Interaktionspartner

  1. The results suggest that P2Y12 is a useful marker for the identification of human microglia throughout the lifespan. Moreover, P2Y12 expression might help to discriminate activated microglia and infiltrating myeloid cells from quiescent microglia in the human CNS.

  2. P2RY12, the gene related to thrombogenesis was differentially expressed between the left atrium and right atrium in Sinus rhythm and Atrial fibrillation. Therefore, the changes in the expression of these genes were likely involved in the pathophysiology of AF-related thrombus formation.

  3. Abnormalities of P2Y12 receptor include congenital deficiencies or high activity in diseases like diabetes mellitus and chronic kidney disease, exposing such patients to a prothrombotic condition. (Review)

  4. Data suggest that PAR4 (zeige PAWR Antikörper) and P2Y12 heterodimer internalization/endocytosis is required for beta-arrestin-2 (zeige ARRB2 Antikörper) recruitment to endosomes and up-regulation of Akt (zeige AKT1 Antikörper) signaling; activation of PAR4 (zeige PAWR Antikörper) but not of P2Y12 drives internalization of the PAR4 (zeige PAWR Antikörper)-P2Y12 heterodimer. (PAR4 (zeige PAWR Antikörper) = protease-activated receptor 4 (zeige F2RL3 Antikörper); P2Y12 = purinergic receptor P2Y (zeige P2RY1 Antikörper), G-protein coupled, 12 protein; Akt (zeige AKT1 Antikörper) = proto-oncogene (zeige RAB1A Antikörper) protein c (zeige PROC Antikörper)-akt (zeige AKT1 Antikörper))

  5. Studies indicate that purinergic receptor P2Y12 (P2Y12 receptor) gene C34T and G52T polymorphism might be a risk factor for the poor response to the platelet in patients on clopidogrel therapy.

  6. studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation.

  7. apart from the established association of the CYP2C19 *2 and *3 LOF alleles with high on-treatment platelet reactivity (HTPR), haplotypes of P2RY12 rs6798347, rs6787801, rs6801273, and rs6785930 rather than rs2046934 (T744C) that related to pharmacodynamics of clopidogrel in patients with ACS were independently associated with HTPR

  8. The present report illustrates an update of dysfunctional platelet P2Y12R mutations diagnosed with congenital lifelong bleeding problems. [review]

  9. aim of this study was to evaluate the effects of platelet receptor gene (P2Y12, P2Y1 (zeige P2RY1 Antikörper)) and glycoprotein gene (GPIIIa (zeige ITGB3 Antikörper)) polymorphisms, as well as their interactions, on antiplatelet drug responsiveness and clinical outcomes in patients with acute MIS (zeige AMH Antikörper)

  10. The Conundrum of Platelet P2Y12 Inhibition in ST-Segment Elevation Myocardial Infarction.

P2RY12 Antigen-Profil

Protein Überblick

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

Genbezeichner und Symbole assoziert mit P2RY12

  • purinergic receptor P2Y, G-protein coupled 12 (P2ry12) Antikörper
  • purinergic receptor P2Y12 (P2RY12) Antikörper
  • purinergic receptor P2Y12 (P2ry12) Antikörper
  • 2900079B22Rik Antikörper
  • 4921504D23Rik Antikörper
  • ADPG-R Antikörper
  • BDPLT8 Antikörper
  • HORK3 Antikörper
  • P2T(AC) Antikörper
  • P2Y(12)R Antikörper
  • P2Y(AC) Antikörper
  • P2Y(ADP) Antikörper
  • P2Y(cyc) Antikörper
  • P2y12 Antikörper
  • SP1999 Antikörper

Bezeichner auf Proteinebene für P2RY12

P2Y purinoceptor 12 , ADP-glucose receptor , G-protein coupled receptor SP1999 , Gi-coupled ADP receptor HORK3 , P2Y12 platelet ADP receptor , purinergic receptor P2RY12 , putative G-protein coupled receptor

GENE ID SPEZIES
70839 Mus musculus
64805 Homo sapiens
64803 Rattus norvegicus
442958 Canis lupus familiaris
Ausgewählte Anbieter für anti-P2RY12 (P2RY12) Antikörper
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