anti-Polymerase (DNA Directed), gamma (POLG) Antikörper

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. Zusätzlich bieten wir Ihnen POLG Proteine (32) und POLG Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
POLG 5428 P54098
POLG 18975  
POLG 85472 Q9QYV8
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Top anti-POLG Antikörper auf

Showing 10 out of 56 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB Western Blot: DNA Polymerase gamma Antibody [NBP1-52300] - Analysis of anti-POLG antibody with (30 ug of whole cell lysate). A: 293T. 5% SDS PAGE. POLG antibody diluted at 1:5000. Immunocytochemistry/Immunofluorescence: DNA Polymerase gamma Antibody [NBP1-52300] - Analysis of anti-POLG antibody with methanol-fixed HeLa cell at 1:200 dilution. 0.05 mL Anmelden zum Anzeigen 5 bis 8 Tage
341,00 €
Human Kaninchen Unkonjugiert EIA, FACS, IF, IHC (p), WB   0.4 mL Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human laryngeal tissue labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 18 bis 22 Tage
304,36 €
Human Kaninchen Unkonjugiert IF, IHC (p), WB Immunofluorescence analysis of methanol-fixed HeLa, using DNA polymerase gamma antibody at 1:200 dilution. Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
Maus Kaninchen Unkonjugiert FACS, IF, IHC (p), WB POLG Antibody (C-term)  western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the POLG antibody detected the POLG protein (arrow). POLG Antibody (C-term)  flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: DNA Polymerase gamma Antibody [NBP1-33633] - Paraffin-embedded Skeletal Muscle, using antibody 10 ug/ml. Western Blot: DNA Polymerase gamma Antibody [NBP1-33633] - Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
341,00 €
Human Kaninchen Unkonjugiert ICC, IF, IP, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human skeletal muscle, using DNA polymerase gamma, antibody(10 μg/ml). 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €

POLG Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine) ,
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Am meisten referenzierte anti-POLG Antikörper

  1. Human Polyclonal POLG Primary Antibody für ICC, IF - ABIN4305533 : Wu, Li, Zhang, Wu, Huang, Chen: Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine. in Mutation research 2009 (PubMed)
    Zeige alle 3 Referenzen für 4305533

  2. Cow (Bovine) Polyclonal POLG Primary Antibody für WB - ABIN2783430 : Mancini, Roncaglia, Brussino, Stevanin, Lo Buono, Krmac, Maltecca, Gazzano, Bartoletti Stella, Calvaruso, Iommarini, Cagnoli, Forlani, Le Ber, Durr, Brice, Ghigo, Casari, Porcelli, Funaro, Gasparre et al.: Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. ... in BMC medical genomics 2013 (PubMed)

  3. Human Polyclonal POLG Primary Antibody für IF (p), IHC (p) - ABIN1714946 : Chen, Zhao, Cai, Sun, Hu, Huang, Kong, Kong: The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways. in Redox biology 2017 (PubMed)

Weitere Antikörper gegen POLG Interaktionspartner

Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), gamma (POLG) Interaktionspartner

  1. The stimulatory effect of mtSSB (zeige SSBP1 Antikörper) on Pol gamma on these ssDNA templates is not species-specific.

  2. Muscle-specific (zeige EIF3K Antikörper) overexpression of the catalytic subunit of DNA polymerase gamma induces pupal lethality in Drosophila melanogaster.

  3. mtSSB (zeige SSBP1 Antikörper) uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells

  4. DNA-binding mutants of mitochondrial single-stranded DNA-binding protein (zeige RPA1 Antikörper) are defective in stimulation of DNA synthesis by pol gamma

Human Polymerase (DNA Directed), gamma (POLG) Interaktionspartner

  1. The rs758130 in POLG gene was significantly associated with the prognosis of patients in a dose-dependent manner. Moreover, GG genotype in rs1061316 showed significantly high mtDNA content, an indicator of better prognosis.

  2. Pol G composes the mtDNA replication machinery, this replication machinery and failure to repair these mtDNA errors results in mtDNA mutations and as a result mitochondrial dysfunction - a major driving force behind aging and age-related diseases.

  3. POLG mutations are associated with progressive external ophthalmoplegia.

  4. tudies on the impact of mitochondrial DNA variants present conflicting data but highlight POLG as a particularly interesting candidate gene for both male and female infertility.

  5. This review presented that the patient with epilepsy due to homozygous pathogenic variants located in the linker region of POLG were associated with later age of onset and longer survival compared to compound heterozygous variants.

  6. MGME1 processes flaps into ligatable nicks in concert with DNA polymerase gamma during mtDNA replication.

  7. Study further demonstrated the broad POLG-related spectrum and led to the identification of Sensory Ataxic Neuropathy with Ophthalmoparesis but without dysarthria (SANO), a new yet common phenotype of this spectrum characterized by the lack of cerebellar signs and by a less severe prognosis than in Sensory Ataxic Neuropathy, Dysarthria and Ophthalmoparesis (SANDO) and Spino (zeige PPP1R9B PLURAL_@14456@) Cerebellar Ataxia (zeige USP14 PLURAL_@14456@) with Epilepsy (SCAE)

  8. molecular dynamics simulations of the human Pol gamma replicative complex

  9. Overall, POLG interactome mapping identifies novel proteins which support mitochondrial biogenesis and a potential novel mitochondrial isoform of Ruvbl2 (zeige RUVBL2 Antikörper).

  10. lymphocytes with POLG mutations are more sensitive than control cells to oxidative stress-induced (zeige SQSTM1 Antikörper) apoptosis.

Mouse (Murine) Polymerase (DNA Directed), gamma (POLG) Interaktionspartner

  1. Cardiac mitochondrial polymerase gamma dysfunction alters nuclear DNA methylation (zeige HELLS Antikörper).

  2. Taken together, our findings may provide clues to further investigate the molecular mechanism underlying premature aging phenotype in Polg mutant mice.

  3. POLG's 3'-5' exonuclease (zeige EXOSC10 Antikörper) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  4. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts.

  5. mitochondrial respiratory chain proteins are specifically decreased in abundance in the brains of the polg mutator mice, including several nuclear encoded mitochondrial components.

  6. in a mouse odel of diabetic retinopathy, POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulatory region of POLG hyper-methylated even after three months of glycemic control

  7. This method gives us insights into the pausing of two pol-gamma variants: the A467T substitution that causes PEO (zeige C10ORF2 Antikörper) and Alpers syndrome, and the exonuclease (zeige EXO1 Antikörper) deficient pol-gamma (exo (zeige XRN1 Antikörper)(-)) in premature aging mouse models.

  8. reduced diabetic symptoms of aging Polg (D257A mutation in mitochondrial DNA polymerase gamma) Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis

  9. Control region multimers demonstrate that polymerase-gamma 3'-5' exonuclease (zeige EXOSC10 Antikörper) activity is required for preserving mtDNA integrity.

  10. causative link between mtDNA mutations and ageing phenotypes, seen in Polg mutant knock-in mice

POLG Antigen-Profil

Protein Überblick

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Genbezeichner und Symbole assoziert mit POLG

  • tamas (tam) Antikörper
  • polymerase (DNA directed), gamma (POLG) Antikörper
  • DNA polymerase gamma 35kD (DNApol-gamma35) Antikörper
  • polymerase (DNA directed), gamma (polg) Antikörper
  • polymerase (DNA directed), gamma (Polg) Antikörper
  • 34Dc Antikörper
  • AA409516 Antikörper
  • AAC47658 Antikörper
  • anon-34Dc Antikörper
  • BG:DS00941.6 Antikörper
  • BG:DS00941.9 Antikörper
  • br5 Antikörper
  • br16 Antikörper
  • cDNA 2 Antikörper
  • CG8969 Antikörper
  • CG8987 Antikörper
  • CG33084 Antikörper
  • CG33650 Antikörper
  • D-pol gamma-alpha Antikörper
  • D-pol gamma-beta Antikörper
  • Dmel\\CG8987 Antikörper
  • Dmel\\CG33650 Antikörper
  • DNA pol-gam.35 Antikörper
  • DNApol-gamma Antikörper
  • DNApol-gamma.35 Antikörper
  • DNApol-gamma125 Antikörper
  • l(2)34Dc Antikörper
  • l(2)34De Antikörper
  • l(2)br5 Antikörper
  • l(2)br14 Antikörper
  • l(2)br16 Antikörper
  • l(2)brS Antikörper
  • MDP1 Antikörper
  • MIRAS Antikörper
  • mtDNA pol Antikörper
  • MTDPS4A Antikörper
  • MTDPS4B Antikörper
  • mtPolA Antikörper
  • MtPolB Antikörper
  • PEO Antikörper
  • PolG Antikörper
  • POLG1 Antikörper
  • PolgA Antikörper
  • polgamma Antikörper
  • pol gamma Antikörper
  • pol gamma-alpha Antikörper
  • polgamma-alpha Antikörper
  • polgamma-beta Antikörper
  • pol gamma-beta Antikörper
  • pol gamma35 Antikörper
  • SANDO Antikörper
  • SCAE Antikörper
  • Tam Antikörper

Bezeichner auf Proteinebene für POLG

CG8987-PA , DNA polymerase gamma , DNA polymerase gamma 125kD , alpha subunit , catalytic subunit of the mitochondrial DNA polymerase , catalytic(alpha)subunit , lethal 14 in the black-reduced region , lethal 5 in the black-reduced region , lethal(2)34Dc , mitochondrial gamma polymerase , mtDNA polymerase alpha , tam-PA , polymerase (DNA directed), gamma , CG33650-PA , DNA polymerase -gamma , DNApol-gamma35-PA , accessory subunit of mitochondrial DNA polymerase , accessory(beta)subunit , beta subunit , lethal 16 in the black-reduced region , lethal(2)34De , mitochondrial DNA polymerase accessory subunit , DNA polymerase subunit gamma-1-like , DNA polymerase subunit gamma-1 , PolG-alpha , mitochondrial DNA polymerase catalytic subunit , DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) , Pol gamma , mitochondrial DNA polymerase gamma , mitochondrial DNA polymerase-gamma , mitochondrial polymerase gamma , polG-alpha , polymerase, gamma , DNA-directed DNA polymerase gamma

34792 Drosophila melanogaster
467754 Pan troglodytes
488732 Canis lupus familiaris
699750 Macaca mulatta
3772064 Drosophila melanogaster
100038061 Xenopus (Silurana) tropicalis
100053827 Equus caballus
100408039 Callithrix jacchus
5428 Homo sapiens
18975 Mus musculus
85472 Rattus norvegicus
404292 Gallus gallus
397851 Xenopus laevis
Ausgewählte Anbieter für anti-POLG (POLG) Antikörper
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