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IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Zusätzlich bieten wir Ihnen IKZF3 Antikörper (147) und IKZF3 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros (zeige IKZF1 Proteine) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF (zeige TNFSF13B Proteine) and Aiolos may prime CD27 (zeige CD27 Proteine)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF (zeige TNFSF13B Proteine) and proinflammatory cytokines.
this study shows that Ikaros (zeige IKZF1 Proteine) undergoes a transient increase in protein levels at the transitional single-positive CD8 (zeige CD8A Proteine)+ developmental stage before diverging in their expression patterns at later stages
Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants.
results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA
Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.
NFKB1 (zeige NFKB1 Proteine), CD27 (zeige CD27 Proteine), LAG3 (zeige LAG3 Proteine) and IKZF3 are new susceptibility genes for psoriasis.
lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (zeige NFKB1 Proteine) activity.
The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (zeige ZPBP2 Proteine) locus confers risk for early-onset psoriasis.
A strong association between rs907091 in the IKZF3 gene and SLE was identified.
The immunosuppressive enzyme IL4I1 (zeige IL4I1 Proteine) expressed differentially in human induced Aiolos+, but not natural Helios (zeige ZNFN1A2 Proteine)+, FOXP3 (zeige FOXP3 Proteine)+ Treg cells.
These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.
study demonstrated that Aiolos silenced the Il2 (zeige IL2 Proteine) locus, promoting TH17 differentiation in vitro and in vivo
Aiolos and Ikaros (zeige IKZF1 Proteine) bind to the c-myc (zeige MYC Proteine) promoter in vivo and directly suppress c-myc (zeige MYC Proteine) expression in pre-B cells.
Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.
A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (zeige IL4 Proteine)-deprived cells via association to the transcription factor Aiolos.
Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.
A novel role for OBF-1 (zeige POU2AF1 Proteine) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (zeige BCR Proteine) function.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
zinc finger protein Aiolos
, zinc finger protein, subfamily 1A, 3 (Aiolos)
, lymphoid transcription factor
, IKAROS family zinc finger 3 (Aiolos)
, ikaros family zinc finger protein 3
, zinc finger protein Aiolos-like