IKAROS Family Zinc Finger 3 (Aiolos) Proteine (IKZF3)

IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Zusätzlich bieten wir Ihnen IKZF3 Antikörper (139) und IKZF3 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IKZF3 22806 Q9UKT9
IKZF3 22780 O08900
Ratte IKZF3 IKZF3 303511  
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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IKZF3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) Interaktionspartnern

Mouse (Murine) IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) Interaktionspartner

  1. These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.

  2. study demonstrated that Aiolos silenced the Il2 (zeige IL2 Proteine) locus, promoting TH17 differentiation in vitro and in vivo

  3. Aiolos and Ikaros (zeige IKZF1 Proteine) bind to the c-myc (zeige MYC Proteine) promoter in vivo and directly suppress c-myc (zeige MYC Proteine) expression in pre-B cells.

  4. Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.

  5. A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (zeige IL4 Proteine)-deprived cells via association to the transcription factor Aiolos.

  6. Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.

  7. A novel role for OBF-1 (zeige POU2AF1 Proteine) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (zeige BCR Proteine) function.

Human IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) Interaktionspartner

  1. this study shows that Ikaros (zeige IKZF1 Proteine) undergoes a transient increase in protein levels at the transitional single-positive CD8 (zeige CD8A Proteine)+ developmental stage before diverging in their expression patterns at later stages

  2. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants.

  3. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA

  4. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.

  5. NFKB1 (zeige NFKB1 Proteine), CD27 (zeige CD27 Proteine), LAG3 (zeige LAG3 Proteine) and IKZF3 are new susceptibility genes for psoriasis.

  6. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (zeige NFKB1 Proteine) activity.

  7. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (zeige ZPBP2 Proteine) locus confers risk for early-onset psoriasis.

  8. A strong association between rs907091 in the IKZF3 gene and SLE was identified.

  9. The immunosuppressive enzyme IL4I1 (zeige IL4I1 Proteine) expressed differentially in human induced Aiolos+, but not natural Helios (zeige ZNFN1A2 Proteine)+, FOXP3 (zeige FOXP3 Proteine)+ Treg cells.

  10. A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population.

IKZF3 Protein Überblick

Protein Überblick

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Genbezeichner und Symbole assoziert mit IKZF3

  • IKAROS family zinc finger 3 (Aiolos) (IKZF3)
  • IKAROS family zinc finger 3 (Aiolos) (ikzf3)
  • IKAROS family zinc finger 3 (Ikzf3)
  • 5830411O07Rik Protein
  • aio Protein
  • Aiolos Protein
  • IKZF3 Protein
  • Zfpn1a3 Protein
  • Znfn1a3 Protein

Bezeichner auf Proteinebene für IKZF3

zinc finger protein Aiolos , zinc finger protein, subfamily 1A, 3 (Aiolos) , lymphoid transcription factor , IKAROS family zinc finger 3 (Aiolos) , ikaros family zinc finger protein 3 , zinc finger protein Aiolos-like

GENE ID SPEZIES
22806 Homo sapiens
444381 Xenopus laevis
395614 Gallus gallus
468232 Pan troglodytes
491020 Canis lupus familiaris
540676 Bos taurus
698083 Macaca mulatta
100015975 Monodelphis domestica
100085644 Ornithorhynchus anatinus
100392424 Callithrix jacchus
100445787 Pongo abelii
100604740 Nomascus leucogenys
22780 Mus musculus
303511 Rattus norvegicus
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