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Huntingtin Associated Protein 1 (HAP1) ELISA Kits

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. Zusätzlich bieten wir Ihnen HAP1 Antikörper (85) und HAP1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus HAP1 HAP1 11792 P28352
HAP1 9001 P54257
Anti-Ratte HAP1 HAP1 29430 P54256
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 15.6 pg/mL 62.5-4000 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 9 bis 12 Tage
772,39 €

Weitere ELISA Kits für HAP1 Interaktionspartner

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) Interaktionspartner

  1. Is closely associated with upregulation of the Ref1 (zeige THOC4 ELISA Kits)/Nrf2 (zeige NFE2L2 ELISA Kits) signalling pathway.

  2. Results show the stimulatory effect of PARP-1 (zeige PARP1 ELISA Kits) on APE1 (zeige APEX1 ELISA Kits)-dependent base excision repair (BER). PARP-1 (zeige PARP1 ELISA Kits) and APE1 (zeige APEX1 ELISA Kits) appear to have a functional interaction in BER since PARP-1 (zeige PARP1 ELISA Kits) can stimulate the strand incision activity of APE1 (zeige APEX1 ELISA Kits).

  3. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

  4. Hap1 interacts with Bcr (zeige BCR ELISA Kits) on microtubules to regulate neuronal differentiation.

  5. increases in APEX1 (zeige APEX1 ELISA Kits) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (zeige APEX1 ELISA Kits) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells

  6. Endothelial cell tumor proliferation was found to be dependent on Apex-1 (zeige APEX1 ELISA Kits) expression.

  7. Expression of OGG1 (zeige OGG1 ELISA Kits) and APEX1 (zeige APEX1 ELISA Kits) was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 (zeige APEX1 ELISA Kits) was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.

  8. Data indicate that the endonuclease activity of APE1 is required for class switch recombination (CSR).

  9. These results suggest that mitochondrial APE1/Ref-1 (zeige APEX1 ELISA Kits) is contributed to the protective role to protein kinase C (zeige PKC ELISA Kits)-induced mitochondrial dysfunction in endothelial cells.

  10. Spinal motor neurones down-regulate APE1 (zeige APEX1 ELISA Kits) upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions.

Human Huntingtin Associated Protein 1 (HAP1) Interaktionspartner

  1. data fully support that HAP1 (zeige APEX1 ELISA Kits) is a GKAP (zeige DLGAP1 ELISA Kits), anchoring specifically to the cGMP-dependent protein kinase (zeige CDK7 ELISA Kits) isoform Ibeta, and provide further evidence that also PKG (zeige PRKG1 ELISA Kits) spatiotemporal signaling is largely controlled by anchoring proteins

  2. HAP1 (zeige APEX1 ELISA Kits) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

  3. Overexpression of HAP1 (zeige APEX1 ELISA Kits) reduced in vitro cell growth in breast cancer cell lines.

  4. The results of this study found no association was found between the HAP1 (zeige APEX1 ELISA Kits) T441M polymorphism and the age at onset of Huntington's disease .

  5. The results of this study suggested that HAP1 (zeige APEX1 ELISA Kits) co-localizes and associates with APP (zeige APP ELISA Kits) in physiological conditions of mouse and human brain.

  6. WT HTT (zeige HTT ELISA Kits) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (zeige PCM1 ELISA Kits)).

  7. HAP1 (zeige APEX1 ELISA Kits)/stigmoid body interacts with the normal ataxin-3 (zeige ATXN3 ELISA Kits) through Josephin (zeige ATXN3 ELISA Kits) domain

  8. sortilin (zeige SORT1 ELISA Kits) stabilizes the proBDNF.HAP1 complex

  9. ADORA2A (zeige ADORA2A ELISA Kits), but not HAP1 (zeige APEX1 ELISA Kits) or OGG1 (zeige OGG1 ELISA Kits), may have a role in age at onset in Huntington's disease

  10. REVIEW: function of HAP1 (zeige APEX1 ELISA Kits)

HAP1 Antigen-Profil

Beschreibung des Gens

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit HAP1

  • apurinic/apyrimidinic endonuclease 1 (Apex1) Antikörper
  • huntingtin-associated protein 1 (HAP1) Antikörper
  • huntingtin-associated protein 1 (Hap1) Antikörper
  • APE Antikörper
  • Apex Antikörper
  • HAP-1 Antikörper
  • HAP1 Antikörper
  • HAP1-A Antikörper
  • HAP1-B Antikörper
  • HAP2 Antikörper
  • hHLP1 Antikörper
  • HIP5 Antikörper
  • HLP Antikörper
  • Ref-1 Antikörper

Bezeichner auf Proteinebene für HAP1

AP endonuclease 1 , APEN , APEX nuclease , DNA-(apurinic or apyrimidinic site) lyase , apurinic-apyrimidinic endonuclease 1 , redox factor-1 , HAP-1 , huntingtin-associated protein 2 , neuroan 1 , huntingtin-associated protein 1 (neuroan 1)

11792 Mus musculus
9001 Homo sapiens
15114 Mus musculus
29430 Rattus norvegicus
607751 Canis lupus familiaris
618422 Bos taurus
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