anti-Hermansky-Pudlak Syndrome 4 (HPS4) Antikörper

HPS4 encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). Zusätzlich bieten wir Ihnen HPS4 Kits (12) und HPS4 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HPS4 89781 Q9NQG7
Anti-Maus HPS4 HPS4 192232 Q99KG7
Anti-Ratte HPS4 HPS4 304555  
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunohistochemistry: HPS4 Antibody [NBP2-31898] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: HPS4 Antibody [NBP2-31898] - Staining of human cell line A-431 shows positivity in centrosome. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Human Kaninchen Unkonjugiert IHC, ELISA, WB   200 μL Anmelden zum Anzeigen 10 bis 13 Tage
560,48 €

HPS4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Human ,

Weitere Antikörper gegen HPS4 Interaktionspartner

Human Hermansky-Pudlak Syndrome 4 (HPS4) Interaktionspartner

  1. BLOC-3 is a Rab32 (zeige RAB32 Antikörper) and Rab38 (zeige RAB38 Antikörper) guanine nucleotide exchange factor (zeige RASGRF1 Antikörper), with a specific function in the biogenesis of lysosome-related organelles. Silencing of the BLOC-3 subunits Hps1 (zeige HPS1 Antikörper) and Hps4 results in the mislocalization of Rab32 (zeige RAB32 Antikörper) and Rab38 (zeige RAB38 Antikörper).

  2. These findings suggested the involvement of HPS4 in the working memory of healthy subjects and in the executive function deficits in schizophrenia.

  3. These results suggest that the HPS4 gene confers a susceptibility to schizophrenia.

  4. Seven mutations (six previously unreported) were described in the HPS1 (zeige HPS1 Antikörper), HPS4, and HPS5 (zeige HPS5 Antikörper) genes among Hermansky-Pudlak Syndrome patients of Mexican, Uruguayan, Honduran, Cuban, Venezuelan, and Salvadoran ancestries.

  5. Data show that recombinant HPS1 (zeige HPS1 Antikörper)-HPS4 produced in insect cells can be efficiently isolated as a 1:1 heterodimer, and might function as a Rab9 (zeige RAB9A Antikörper) effector in the biogenesis of lysosome-related organelles.

  6. identification of mutations which establish HPS4 as important in Herman-Pudlak syndrome, and identification of mouse homolog light-ear gene

  7. identification as a component of two complexes, BLOC-3 and BLOC-4, involved in the biogenesis of lysosome-related organelles

  8. Hermansky-Pudlak syndrome type 4 (HPS-4) patients exhibited iris transillumination, variable hair and skin pigmentation, absent platelet dense bodies, and occasional pulmonary fibrosis and granulomatous colitis.

  9. observations demonstrate that the Hermansky-Pudlak syndrome 1(HPS1 (zeige HPS1 Antikörper)) and HPS4 proteins are components of a cytosolic complex that is involved in the biogenesis of lysosomal-related organelles

  10. HPS4 but not HPS3 associates with HPS1 in a complex, which we term biogenesis of lysosome-related organelles complex 3 (BLOC-3)

HPS4 Antigen-Profil

Protein Überblick

This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit HPS4

  • Hermansky-Pudlak syndrome 4 (HPS4) Antikörper
  • Hermansky-Pudlak syndrome 4 homolog (human) (Hps4) Antikörper
  • Hermansky-Pudlak syndrome 4 (Hps4) Antikörper
  • 2010205O06Rik Antikörper
  • AU040608 Antikörper
  • BLOC-3 Antikörper
  • C130020P05Rik Antikörper
  • le Antikörper
  • mKIAA1667 Antikörper

Bezeichner auf Proteinebene für HPS4

Hermansky-Pudlak syndrome 4 protein , light-ear protein homolog , Hermansky-Pudlak syndrome 4 protein homolog , light ear , light-ear protein , Hermansky-Pudlak syndrome 4 homolog

89781 Homo sapiens
192232 Mus musculus
304555 Rattus norvegicus
100721935 Cavia porcellus
101118387 Ovis aries
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