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The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Zusätzlich bieten wir Ihnen FKBP5 Antikörper (127) und FKBP5 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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This study demonstrated suggest that FKBP5 in the GR pathway may be a point of vulnerability to early-life adversity, as seen in this group of non-traumatized young adults.
Association of FKBP5 haplotype with risk of suicide attempt.
This study provides initial evidence that the risk alleles of the FKBP5 polymorphism are associated with different resting-state activity in a frontotemporal-parietal network, and may point to mechanisms underpinning high-risk carriers' vulnerability to severe stress reactions.
This review showed a significant genetic association in most studies in FKBP5 with a high rate of attempted suicide.
Associations between the FKBP5 SNPs, exposure to violence and anxiety in females.
FKBP51 (zeige FKBP4 ELISA Kits) is primarily localized in mitochondria and hTERT is totally nuclear, upon the onset of oxidative stress, FKBP51 (zeige FKBP4 ELISA Kits) (but not FKBP52 (zeige FKBP4 ELISA Kits)) becomes mostly nuclear colocalizing with hTERT, and longer exposure times to peroxide favors hTERT export to mitochondria.
The results show that the presence of the T allele of the FKBP5 SNP rs1360780 was associated with weight loss after bariatric surgery. Bariatric surgery can interact with genes involved in metabolic regulation, leading to different weight loss outcomes
The role of FKBP51 (zeige FKBP4 ELISA Kits) in intracellular pathways involved in adaptation is summarized.
we found no effect of early life trauma on heavy drinking in rs1360780*T-allele carriers, rs1360780*C homozygotes exposed to early life trauma had a lower probability of heavy drinking compared to rs1360780*C homozygotes not exposed to early life trauma (P < 0.01). There exists a developmental period of susceptibility to stress that is moderated by FKBP5 genotype.
LIF (zeige LIF ELISA Kits) and FKBP51 (zeige FKBP4 ELISA Kits) expression in epithelial cells were the most interesting markers of Airway epithelial cells dysfunction/response to corticosteroid treatment.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (zeige HSP90 ELISA Kits) cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context.
Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.
important regulator of PPARgamma (zeige PPARG ELISA Kits) in white adipose tissue
FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice
findings show that miR (zeige MLXIP ELISA Kits)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.
These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.
We discovered that the suggested psychiatric risk factor FK506 binding protein (zeige FKBPL ELISA Kits) 51 (FKBP51) increases phosphorylation of GSK3beta (zeige GSK3b ELISA Kits) at serine 9 (pGSK3beta(S9)).
Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (zeige HELLS ELISA Kits), and its subsequent regulation of glucocorticoid receptor (zeige NR3C1 ELISA Kits) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton
the abundance of BDNF (zeige BDNF ELISA Kits) positively correlated and phosphorylated DNMT1 (zeige DNMT1 ELISA Kits) inversely correlated with that of FKBP51 in cells
FKBP5 associates with BECN1 (zeige BECN1 ELISA Kits), changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
FK506 binding protein 5
, FK506-binding protein 5
, PPIase FKBP5
, peptidyl-prolyl cis-trans isomerase FKBP5
, 51 kDa FK506-binding protein 5
, 51 kDa FKBP
, 54 kDa progesterone receptor-associated immunophilin
, FF1 antigen
, HSP90-binding immunophilin
, T-cell FK506-binding protein
, androgen-regulated protein 6
, peptidylprolyl cis-trans isomerase
, 51 kDa FK506-binding protein