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Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. Zusätzlich bieten wir Ihnen CYFIP1 Antikörper (24) und CYFIP1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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The studies suggest that MNK (zeige ATP7A Proteine)-eiF4E (zeige EIF4E Proteine) axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1. (Review)
rs4778298, a common variant at CYFIP1 is associated with inter-individual variation in surface area across the left supramarginal gyrus.
we show that stapled peptides targeting the interface between NCKAP1 (zeige NCKAP1 Proteine) and CYFIP1 destabilize the WASF3 (zeige WASF3 Proteine) complex... thereby suppressing invasion and metastasis of breast cancer cells.
Both mRNA and protein expression levels of Cyfip1 were significantly lower in ALL patients.
Reduced CYFIP1 in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks.
Hippocampal synapses with reduced Cyfip1 are larger and release neurotransmitter more rapidly.
Data confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time
This study confirmed that CYFIP2 (zeige CYFIP2 Proteine) were altered in postsynaptic density in patient with schizophrenia.
An imbalance of specific isoforms of CYFIP1, an FMRP (zeige FMR1 Proteine) interaction partner, and CAMK4 (zeige CAMK4 Proteine), a transcriptional regulator of the FMRP (zeige FMR1 Proteine) gene, modulates risk for autism spectrum disorders.
Protein complexes containing CYFIP/Sra (zeige SRA1 Proteine)/PIR121 (zeige CYFIP2 Proteine) coordinate Arf1 (zeige ARF1 Proteine) and Rac1 signalling during clathrin-AP-1 (zeige FOSB Proteine)-coated carrier biogenesis at the trans-golgi network.
These results illustrate a new model to explain the cellular roles of FMRP (zeige FMR1 Proteine) and CYFIP1 and the molecular significance of their interaction.
In Cyfip1-deficient mice, parental origin determines the impairment of synaptic functions and behavior.
Data suggest that MAP kinase (zeige MAPK1 Proteine)-interacting kinases (Mnk1 (zeige MKNK1 Proteine), Mnk2 (zeige MKNK2 Proteine)) regulate cell migration/wound healing, expression of vimentin (zeige VIM Proteine), stability of vimentin (zeige VIM Proteine) protein, and binding of cytoplasmic eIF4E (eukaryotic translation initiation factor 4E (zeige EIF4E Proteine)) and Cyfip1.
CYFIP2 (zeige CYFIP2 Proteine) is a key regulator of cocaine response in mammals and present a framework to use mouse substrains to identify previously unknown genes and alleles regulating behavior.
This study demonistrated that CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.
haploinsufficiency of Cyfip1 mimics key aspects of the phenotype of Fmr1 (zeige FMR1 Proteine) knockout mice and are consistent with the hypothesis that these effects are mediated by interaction of Cyfip1 and Fmrp (zeige FMR1 Proteine) in regulating activity-dependent translation.
Sra-1 and Nap1 are constitutive and essential components of a WAVE2- and Abi-1-containing complex linking Rac to site-directed actin assembly.
The translational repression activity of FMRP (zeige FMR1 Proteine) in the brain is mediated, at least in part, by CYFIP1.
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
cytoplasmic FMR1 interacting protein 1
, cytoplasmic FMR1-interacting protein 1
, cytoplasmic FMRP interacting protein 1
, selective hybridizing clone
, specifically Rac1-associated protein 1
, cytoplasmic FMR1-interacting protein 1 homolog