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May act as a receptor in regulating T-cell proliferation.. Zusätzlich bieten wir Ihnen CD5 Antikörper (1366) und CD5 Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.
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FasL (zeige FASL ELISA Kits) expression in splenic CD5(+)CD1d (zeige CD1D ELISA Kits)(hi) B cells was decreased compared to the control group after TLR4 (zeige TLR4 ELISA Kits) ligation.
CD5-CK2 signaling axis regulates positive selection by modulating activation of ERK and promoting survival independent of proximal TCR signals
the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency.
In mice lacking functional KDELR1, surviving naive T cells expressed significantly higher levels of CD5, a surrogate marker of TCR self-reactivity.
In mouse tumor models, CD5(+) but not CD5(-) B cells promoted tumor growth. The results demonstrate a critical role of CD5(+) B cells in promoting cancer.
CD5 and CD72 (zeige CD72 ELISA Kits) play a critical role in maintaining regulatory T and B cell homeostasis
CD5 promoted Treg cell induction in response to self and tolerizing antigens by blocking mTOR (zeige FRAP1 ELISA Kits) activation.
Data indicate that CD5-casein kinase 2 (CK2 (zeige CSNK2A1 ELISA Kits)) signaling is necessary for efficient nuclear localization of orphan nuclear receptor (zeige NR1D1 ELISA Kits) ROR (zeige RORB ELISA Kits)-gammaT (RORgammat).
These results support the notion that the distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via c-Cbl (zeige CBL ELISA Kits).
Although the percentage of CD1d (zeige CD1D ELISA Kits)(hi)CD5+ subset in splenic B cells does not change significantly, percent IL-10 (zeige IL10 ELISA Kits)-expressing cells among total splenic B cells or the CD1dhiCD5+ population significantly increases 3-7 days after rCRT/39-272 administration
ZAP70 (zeige ZAP70 ELISA Kits) is the only gene that is differentially expressed in CD5-high and CD5-low normal B-lymphocytes, confirming the key role of Zap-70 (zeige ZAP70 ELISA Kits) tyrosine kinase (zeige TXK ELISA Kits) in BCR (zeige BCR ELISA Kits) signaling alterations in B-CLL.
The high CD5 plasma levels in patients with severe ASD (zeige ARSD ELISA Kits), probably indicated that CD5 might be implicated in the physiology of autism. However, this finding should be treated with caution until further investigations are performed with larger populations to determine whether the increase in plasma CD5 levels is a mere consequence of autism or it plays a pathogenic role in the disease.
A CD34 (zeige CD34 ELISA Kits)-negative MYC (zeige MYC ELISA Kits)-rearranged B-lymphoblastic lymphoma aberrantly expresses CD3 (zeige CD3 ELISA Kits) and CD5.
study provides understanding of the regulation of CD5 expression on leukaemic T cells, and may help in understanding the molecular mechanism of CD5 down-regulation.
CD5 transcription is increased, leading to the production of three mRNA isoforms by APA (zeige ENPEP ELISA Kits), all contributing for protein production, at different levels. PTBP1 (zeige PTBP1 ELISA Kits) binds in the vicinity of pA1 (zeige PAGR1 ELISA Kits), leading to an increase in mRNA levels and miR (zeige MLXIP ELISA Kits)-204 targets the longer CD5 mRNA.
High CD5 expression is associated with lymphoma in Waldeyer ring.
Thus, trans-signaling of IL-6 (zeige IL6 ELISA Kits) can only occur via sIL (zeige PMEL ELISA Kits)-6R, but not sCD5 (zeige SCD5 ELISA Kits).
The major proportion of CD5(low) B cells in patients are leukemic, thus identifying CD5(low) B cells as an important component of CLL, with implications for CLL pathogenesis, clinical monitoring, and the development of anti-CD5-directed therapies.
the CD5 Pro224-Ala471 haplotype in homozygosis improved melanoma survival in the entire set of patients (HR = 0.27, 95% CI 0.11-0.67, Adj. p = 0.005). These findings highlight the relevance of genetic variability in immune-related genes for clinical outcome in melanoma.
R-EPOCH therapy does not seem to impact the known poorer prognosis of patients with de novo CD5+ diffuse large B-cell lymphoma , and CD5 expression was still an independent prognostic factor in R-EPOCH-treated patients with diffuse large B-cell lymphoma.
Findings suggest that development, selection and function of different B- and T-cell subsets may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like (zeige CD5L ELISA Kits) molecules expressed on T cells compared to B (zeige TDO2 ELISA Kits) cells.
May act as a receptor in regulating T-cell proliferation.
, t-cell surface glycoprotein CD5-like
, T-cell surface glycoprotein CD5
, lymphocyte antigen 1
, CD5 antigen (p56-62)
, lymphocyte antigen T1/Leu-1
, CD5 antigen
, Lymphocyte antigen CD5
, CD74 antigen, invariant polypeptide of major
, lymphocyte receptor CD5