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APOB product is the main apolipoprotein of chylomicrons and low density lipoproteins. Zusätzlich bieten wir Ihnen APOB Antikörper (359) und APOB Kits (132) und viele weitere Produktgruppen zu diesem Protein an.
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Identify LDLR (zeige LDLR Proteine), APOB and PCSK9 (zeige PCSK9 Proteine) novel mutations causing familial hypercholesterolemia in the central south region of China.
Rare variants of APOB or PCSK9 (zeige PCSK9 Proteine) were identified in nine of the 22 study patients with extremely low LDL-C levels
Eicosapentaenoic acid has direct antioxidant benefits in various apoB-containing subfractions.
Association of plasma apoB with IR in obese subjects is dependent on gynoid WAT dysfunction
Serum ApoB was not significantly different between term SGA newborns and control term newborns.
This study showed that the predictive value of apolipoprotein B/A-I ratio for coronary artery calcification may differ according to kidney function.
APOB associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age =65 years, and LDL-C levels >/=160 mg/dl.
we identified common intronic SNPs (rs676210 and rs1042034) in the APOB gene and found five SNPs that were collectively associated with hyperlipidemia in the adult Chinese Yugur population. Importantly, we demonstrated that the G allele of rs676210 may confer an increased risk of hyperlipidemia.
APOB missense variants, A224T and V925L, in a black South African woman with marked hypocholesterolemia
male gender, ageing in women and menopause were associated with increased apoB concentrations.
enhanced VLDL TG secretion in the absence of hepatocyte ABCA1 (zeige ABCA1 Proteine) is due to altered intracellular trafficking of apolipoprotein B (apoB), resulting in augmented TG addition to nascent VLDL.
We carried out our experiment in mice deficient in the low density lipoprotein (LDL) receptor (zeige LDLR Proteine) and expressing only ApoB100 molecule (ApoB - LDLr (zeige LDLR Proteine)) where the development of atherosclerosis is known to closely mimic human atherosclerosis
The effect of hypercholesterolemia induced immune response and inflammation on progression of atherosclerosis in ApoB(tm25gy) LDLr (zeige LDLR Proteine)(tm1Her) mice, expressing only ApoB100 and deficient in the low density lipoprotein receptor (zeige LDLR Proteine).
ApoB-containing lipoproteins contribute to augmentation of AngII-induced abdominal aortic aneurysms in male mice.
Immunization with human apolipoprotein B100 (ApoB) resulted in four-fold increased accumulation of effector T cells in ApoB-containing matrigel
PCSK9 (zeige PCSK9 Proteine) markedly increases intestinal triglyceride-rich apoB production through mechanisms mediated in part by transcriptional effects on apoB.
Mice that produce apoB100 in the RPE (zeige RPE Proteine) and liver secrete lipoproteins into Bruch's membrane, but not to the extent that distinct features of AMD (zeige AMD1 Proteine) develop
The aim of this study was to characterize the ocular morphology of low-density lipoprotein receptor-deficient apolipoprotein B-100-only mice, with IGF-II overexpression.
Our data establish the role of APOB gene in severe gut (zeige GUSB Proteine) dysmotility.
Cardiac lipotoxicity may originate from direct inhibition of myocardial ApoB lipoprotein and subsequent decreased lipid export, caused by supraphysiological levels of catecholamines.
Beyond malabsorption of dietary lipids, deleterious effects of apolipoprotein B deficiency on hepatic lipid metabolism, steroid biosynthesis, and cell membrane function can be expected, which may result in unspecific symptoms of reduced fertility, growth, and health.
Cholesterol deficiency results from a 1.3kbp insertion of an endogenous retrovirus (ERV2-1-LTR_BT) into exon 5 of the APOB gene at BTA11:77,959kb. The insertion is flanked by 6bp target site duplications as described for insertions mediated by retroviral integrases.
A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle
Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE (zeige APOE Proteine), MTP (zeige MTTP Proteine), and LDLR (zeige LDLR Proteine), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (zeige MTTP Proteine)) and apolipoprotein E (zeige APOE Proteine) messenger RNA abundance were higher in the liver.
found association between genotypes for LDLR (zeige LDLR Proteine) and APOB polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
, apolipoprotein B (including Ag(x) antigen)
, apolipoprotein B-100
, apolipoprotein B48
, mutant Apo B 100
, apolipoprotein B PI
, apolipoprotein B-48
, apolipoprotein B