SMAD3 Proteine (SMAD3)

Bezeichnung:
SMAD, Mothers Against DPP Homolog 3 Proteine (SMAD3)
Auf www.antikoerper-online.de finden Sie aktuell 27 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMAD3 Antikörper (515) und SMAD3 Kits (57) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 642 SMAD3 Produkte verfügbar.
Synonyme:
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
alle Proteine anzeigen Gen GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

Weitere Synonyme anzeigen

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Am meisten referenzierte SMAD3 Proteine

  1. Human SMAD3 Protein expressed in Escherichia coli (E. coli) - ABIN666909 : Wang, Song, Sponseller, Danielpour: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. in The Journal of biological chemistry 2005 (PubMed)
    Zeige alle 2 Referenzen für 666909

Weitere Proteine zu SMAD3 Interaktionspartnern

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. Data suggest that Clock1a (zeige CLOCK Proteine) coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 signaling; Clock1a (zeige CLOCK Proteine) alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a (zeige CLOCK Proteine) activates Smad3a promoter via its E-box1 element. (Clock1a (zeige CLOCK Proteine) = clock circadian regulator (zeige CLOCK Proteine) a; Nodal = nodal modulator 1 (zeige NOMO1 Proteine); Smad3a = SMAD (zeige SMAD1 Proteine) family member 3a)

  2. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (zeige TGFB1 Proteine) control of zebrafish spinal cord development

  3. Nodal signaling and mesendoderm induction depend on Smad2 (zeige SMAD2 Proteine)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (zeige SMAD2 Proteine)/3 signaling and embryonic patterning.

  4. although the role of Smad (zeige SMAD1 Proteine) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (zeige TDP2 Proteine) provides insight into a novel Smad (zeige SMAD1 Proteine) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  5. Smad2 (zeige SMAD2 Proteine)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (zeige TGFB1 Proteine)/Smad3 signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. TF-induced microvessel stabilization is regulated via PAR2 (zeige F2RL1 Proteine)-SMAD3 that is indispensable for the maintenance of vascular integrity.

  2. cPLA2alpha (zeige PLA2G4A Proteine) activates PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and inhibits Smad2 (zeige SMAD2 Proteine)/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells.

  3. stablish PPM1A (zeige PPM1A Proteine) as a novel repressor of the SMAD3 pathway in renal fibrosis

  4. Methylation in SMAD3 was selectively increased in asthmatic children of asthmatic mothers and was associated with childhood asthma risk

  5. a direct crosstalk between the STAT3 (zeige STAT3 Proteine) and Smad3 signaling pathways that may contribute to tumor development and inflammation.

  6. It is reported here that TGF-beta (zeige TGFB1 Proteine) directly regulates alternative splicing of cancer stem cell marker CD44 (zeige CD44 Proteine) through a phosphorylated threonine179 of SMAD3-mediated interaction with RNA-binding protein (zeige PTBP1 Proteine) PCBP1 (zeige PCBP1 Proteine).

  7. Bcl-3 (zeige BCL3 Proteine) knockdown enhanced the degradation of Smad3 but not Smad2 (zeige SMAD2 Proteine) following TGFbeta (zeige TGFB1 Proteine) treatment.

  8. miR (zeige MLXIP Proteine)-206 and miR (zeige MLXIP Proteine)-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 (zeige TRIB2 Proteine) promoter activity through p-Smad3.

  9. These studies support previously unrecognized, cooperative interaction between the CCN1 (zeige CCNA2 Proteine) matricellular protein and canonical TGF-beta1 (zeige TGFB1 Proteine)/SMAD3 signaling that promotes lung fibrosis.

  10. c-Abl (zeige ABL1 Proteine) promotes TGF-beta (zeige TGFB1 Proteine)-induced SKIP/Smad3 interaction.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. E2a (zeige TCF3 Proteine) is necessary to drive transcription of Smad2 (zeige SMAD2 Proteine)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. Activin A (zeige INHBA Proteine) and overexpression of SMAD2 (zeige SMAD2 Proteine)/3 significantly promoted expressions of porcine NANOG (zeige NANOG Proteine) and OCT4 (zeige POU5F1 Proteine),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Proteine)/OCT4 (zeige POU5F1 Proteine) expression.

  2. Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition

  3. SP1 (zeige SP1 Proteine) and SMAD3 are required for high glucose-induced p21(WAF1 (zeige CDKN1A Proteine)) gene transcription in LLC-PK1 (zeige PKLR Proteine) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. The results uncover an important aspect of the cross-talk between TGFbeta (zeige TGFB1 Proteine) and Hippo signaling, showing that TGFbeta (zeige TGFB1 Proteine) induces TAZ (zeige TAZ Proteine) via a Smad3-independent, p38 (zeige CRK Proteine)- and MRTF-mediated and yet MRTF translocation-independent mechanism.

  2. Data suggest that Gas5 suppresses Tgfb1 (zeige TGFB1 Proteine)/Smad3 signaling in vascular smooth muscle cell differentiation from mesenchymal progenitor cells; Gas5 competitively binds Smad3 via multiple RNA Smad (zeige SMAD1 Proteine)-binding elements. (Gas5 = growth arrest-specific 5 long non-coding RNA; Tgfb1 (zeige TGFB1 Proteine) = transforming growth factor beta 1 (zeige TGFB1 Proteine); Smad3 = MAD homolog 3 protein)

  3. point mutant that was unable to bind pSMAD3 proved ineffective. These findings indicate that specifically targeting pSMAD3 can ameliorate both the direct and indirect fibroproliferative actions of TGF-beta (zeige TGFB1 Proteine).

  4. Soluble epoxide hydrolase (zeige EPHX2 Proteine) inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38 (zeige CRK Proteine)/Smad3 signaling pathway.

  5. A critical role for the Smad3-c-Jun (zeige JUN Proteine) pathway in the regulation of Fstl1 (zeige FSTL1 Proteine).

  6. Mirtazapine suppressed 5-HT-mediated TGF-beta1/Smad3 and ERK1/2 signaling pathways as well as oxidative stress that contribute to the progression of liver fibrosis.

  7. These results suggest that Nedd9 (zeige NEDD9 Proteine) is a Smad2 (zeige SMAD2 Proteine)/3 target gene implicated in RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis.

  8. These results suggested that TGF-beta1 (zeige TGFB1 Proteine)/Smad3 signaling was activated during CCl4 (zeige CCL4 Proteine)-induced acute liver injury in mice, and Smad3 overexpression aggravated acute liver injury by promoting inflammatory cells infiltration, inflammatory cytokines release and hepatocytes apoptosis.

  9. gonadotropin-releasing hormone receptor (zeige GNRHR Proteine) mRNA levels were significantly elevated in knock-outs in both sexes. Interestingly, luteinizing hormone production was altered in a sex-specific fashion. Overall, our analyses demonstrate that SMAD3 is required for FSH (zeige BRD2 Proteine) synthesis in vivo

  10. Evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization (CNV). The size of the CNV induced was significantly smaller in KO mice as compared with WT mice at day 14.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) Interaktionspartner

  1. the present work provides evidence supporting a functional role of SMAD2 (zeige SMAD2 Proteine)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (zeige SMAD2 Proteine)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2 (zeige SMAD2 Proteine)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).

SMAD3 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3)
  • MAD homolog 3a (Drosophila) (smad3a)
  • mothers against decapentaplegic homolog 3 (LOC100346303)
  • SMAD family member 3 (smad3)
  • SMAD family member 3 (Smad3)
  • AU022421 Protein
  • HSPC193 Protein
  • HsT17436 Protein
  • JV15-2 Protein
  • LDS1C Protein
  • LDS3 Protein
  • mad3 Protein
  • Madh3 Protein
  • madh3-A Protein
  • madh3a Protein
  • Smad 3 Protein
  • smad3 Protein
  • wu:fa99e03 Protein
  • XenMLP Protein
  • Xmad3 Protein
  • XSmad3 Protein

Bezeichner auf Proteinebene für SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

GENE ID SPEZIES
100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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