anti-PLK1 (PLK1) Antikörper

Bezeichnung:
anti-Polo-Like Kinase 1 Antikörper (PLK1)
Auf www.antikoerper-online.de finden Sie aktuell 377 Polo-Like Kinase 1 (PLK1) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PLK1 Kits (14) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 425 PLK1 Produkte verfügbar.
Synonyme:
0256/04, 1324/08, anon-WO0172774.3, cb525, cb636, CG12306, Dmel\CG12306, ik:tdsubc_2d1, l(3)01673, l(3)77Aa, l(3)S025604, l(3)S132408, Plk, PLK-1, PLK1, Plx1, Polo, POLO/PLK1, Polo kinase, Snk, STPK13, wu:fb37g11, wu:fb76g03, xx:tdsubc_2d1
Alle Antikörper anzeigen Gen GeneID UniProt
PLK1 5347 P53350
PLK1 18817 Q07832
Anti-Ratte PLK1 PLK1 25515 Q62673

Alle Spezies anzeigen

Weitere Synonyme anzeigen

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Am meisten referenzierte anti-PLK1 Antikörper

  1. Human Monoclonal PLK1 Primary Antibody für FACS, IHC - ABIN1098105 : Lin, Sun, Wang: Suppression of Polo like kinase 1 (PLK1) by p21(Waf1) mediates the p53-dependent prevention of caspase-independent mitotic death. in Cellular signalling 2011 (PubMed)
    Zeige alle 3 Referenzen für 1098105

  2. Human Monoclonal PLK1 Primary Antibody für WB - ABIN967616 : Ando, Ozaki, Yamamoto, Furuya, Hosoda, Hayashi, Fukuzawa, Nakagawara: Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 3 Referenzen für 967616

  3. Human Monoclonal PLK1 Primary Antibody für ICC, ELISA - ABIN969580 : Lee, Rhee: PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis. in The Journal of cell biology 2011 (PubMed)
    Zeige alle 2 Referenzen für 969580

  4. Human Polyclonal PLK1 Primary Antibody für IHC (p), WB - ABIN392446 : Negishi, Kumano, Nishida: Polo-like kinase 1 is required for localization of Posterior End Mark protein to the centrosome-attracting body and unequal cleavages in ascidian embryos. in Development, growth & differentiation 2011 (PubMed)
    Zeige alle 2 Referenzen für 392446

  5. Human Monoclonal PLK1 Primary Antibody für ICS - ABIN1177153 : Peter, Gleixner, Cerny-Reiterer, Herrmann, Winter, Hadzijusufovic, Ferenc, Schuch, Mirkina, Horny, Pickl, Müllauer, Willmann, Valent: Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536. in Haematologica 2011 (PubMed)

  6. Human Monoclonal PLK1 Primary Antibody für ICS - ABIN1177152 : Jang, Ma, Terada, Erikson: Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase. in The Journal of biological chemistry 2002 (PubMed)

  7. Human Polyclonal PLK1 Primary Antibody für IHC, ELISA - ABIN129581 : Adler, Müller, Rached, Dekant, Mally: Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. in Carcinogenesis 2009 (PubMed)

  8. Cow (Bovine) Polyclonal PLK1 Primary Antibody für IHC, WB - ABIN2782496 : Yamashiro, Yamakita, Totsukawa, Goto, Kaibuchi, Ito, Hartshorne, Matsumura: Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. in Developmental cell 2008 (PubMed)

Weitere Antikörper gegen PLK1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Polo-Like Kinase 1 (PLK1) Interaktionspartner

  1. Study shows that cnn exon1A-encoded proteins interact with Polo at 2 residues and that this interaction is required for polar body and pericentriolar matrix formation in syncytial embryos.

  2. Cdk1 (zeige CDK1 Antikörper) phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles.

  3. Polo is an important in vivo regulator of the pathological functions of APP (zeige APP Antikörper).

  4. Both conditions impaired NSC lineage progression. Ca(2 (zeige CA2 Antikörper)) mito homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro

  5. During pericentriolar matrix formation exon 1A Cnn-Long Form proteins likely bind Polo kinase before phosphorylation by Polo for Cnn transport to the centrosome.

  6. Polo kinase is required for localization and activity of the chromosomal passenger complex in mitosis and meiosis.

  7. Centrioles, which usually separate during the anaphase of the first meiosis, remained held together in a V-shaped configuration suggesting that Polo kinase regulates the proteolysis that breaks centriole linkage to ensure their disengagement.

  8. Results show that Polo kinase positively and negatively regulates Augmin distribution for microtubule nucleation and acentrosomal spindle formation.

  9. Regulation of Polo by Aurora B (zeige AURKB Antikörper) and Map205 is required for cytokinesis.

  10. These data indicate APC (zeige APC Antikörper)(Cort (zeige CORT Antikörper)) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence.

Xenopus laevis Polo-Like Kinase 1 (PLK1) Interaktionspartner

  1. Novel roles for Plk and GSK3 (zeige GSK3b Antikörper) regulation of ADAM13 (zeige ADAM33 Antikörper) function in cranial neural crest cell migration.

  2. Plx1-mediated degradation of Bora in interphase generates oscillations in Plx1 activity and is essential for development.

  3. Coordinated interplays between Plx1 and Gwl (zeige MASTL Antikörper) are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

  4. the penultimate CRS (zeige CARS Antikörper) serine (Ser (zeige SIGLEC1 Antikörper) 101) of cyclin b1 (zeige CCNB1 Antikörper) is a Plx substrate

  5. Results suggest that polo-like kinase (Plx1) could be the missing regulator that prevents maturation-promoting factor autoamplification in stage IV oocytes.

  6. Plx1 cooperates with CaMKII (zeige CAMK2G Antikörper) to regulate cyclosome regulators, and is necessary for release of cytostatic factor metaphase arrest and sufficient when overexpressed.

  7. Data show that Plx1 couples tension signals to cellular responses through phosphorylation of the 3F3 (zeige TRIM32 Antikörper)/2 epitope and targeting structural and checkpoint proteins to kinetochores.

  8. Polo-like kinase Plx1 is an essential factor for calcium ion-induced meiotic exit during cytostatic factor arrest

  9. Polo-like kinase (Plx1) phosphorylates xTRF1 in vitro and the mitotic xTRF1-chromatin association was significantly impaired when Plx1 was immunodepleted from the extracts (Plx1).

  10. Cdk1 (zeige CDK1 Antikörper) phosphorylation of BubR1 (zeige BUB1B Antikörper) controls spindle checkpoint arrest and plk-mediated formation of the 3F3 (zeige TRIM32 Antikörper)/2 epitope.

Human Polo-Like Kinase 1 (PLK1) Interaktionspartner

  1. Mutant IDH1 (zeige IDH1 Antikörper) promotes checkpoint adaptation which can be exploited therapeutically with the combination of TMZ and a PLK1 inhibitor, indicating PLK1 inhibitors may be clinically valuable in the treatment of IDH1 (zeige IDH1 Antikörper) mutant gliomas

  2. Genistein induced mitotic arrest by inhibiting Plk1 activity and, consequently, led to mitotic catastrophe and apoptosis. Tumor cells with TP53 (zeige TP53 Antikörper) mutations were more sensitive to cell death by treatment of genistein.

  3. we show that Plk1 phosphorylates Mre11 (zeige MRE11A Antikörper) at S649 during G2 DNA damage recovery and Mre11 (zeige MRE11A Antikörper) phosphorylation at S649/S689 drives premature checkpoint termination and reduced DNA repair

  4. We propose that the DDR (zeige DDR1 Antikörper) targets recruitment of Aurora A (zeige AURKA Antikörper) to the Plk1/Bora complex to prevent activation of Plk1 during DNA damage in G2.

  5. The findings reveal a PLK1-Fbw7 (zeige FBXW7 Antikörper)-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.

  6. Studies provide evidence that PLK1 plays a role during cell cycle progression and human pediatric cancer. [review]

  7. Small molecule inhibition of polo-like kinase 1 by volasertib (BI 6727) causes significant melanoma growth delay and regression in vivo.

  8. Mutations of the LIM protein (zeige CSRP1 Antikörper) AJUBA (zeige AJUBA Antikörper) mediate sensitivity of head and neck squamous cell carcinomas to treatment with PLK1 inhibitors.

  9. PLK1 may be an important regulator of metabolism maintenance in melanoma cells.

  10. The authors show that a global spread of ATM (zeige ATM Antikörper) activity on chromatin and phosphorylation of ATM (zeige ATM Antikörper) targets including KAP1 (zeige CDKN3 Antikörper) control Plk1 re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1 (zeige PPM1D Antikörper), allowing cell cycle restart despite persistent ATM (zeige ATM Antikörper) activity present at DNA lesions.

Pig (Porcine) Polo-Like Kinase 1 (PLK1) Interaktionspartner

  1. Thus, these results indicated that Plk1 is essential for porcine embryos to complete the first mitotic division. Furthermore, Plk1 regulation was associated with effects on spindle assembly and chromosome arrangement

  2. PLK1 might play a critical role in vascular smooth muscle cell mitosis in hyperplastic intima of the injured vessels.

  3. Data show that Polo-like kinase 1 is activated before M phase promoting factor (MPF (zeige MSLN Antikörper)), which is consistent with its role in activating MPF (zeige MSLN Antikörper) in mammalian oocytes.

Mouse (Murine) Polo-Like Kinase 1 (PLK1) Interaktionspartner

  1. Plk1 regulated angiotensin II-dependent activation of RhoA (zeige RHOA Antikörper) and actomyosin dynamics in VSMCs in a mitosis-independent manner. This regulation depended on Plk1 kinase activity. Plk1 haploinsufficiency in mice did not induce obvious cell proliferation defects but did result in arterial structural alterations, which frequently led to aortic rupture and death.

  2. The findings reveal a PLK1-Fbw7 (zeige FBXW7 Antikörper)-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.

  3. These data implicate the insulin (zeige INS Antikörper)-FoxM1 (zeige FOXM1 Antikörper)/PLK1/CENP-A (zeige CENPA Antikörper) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.

  4. centrosome maturation occurs during interphase in an MLK (zeige MUSK Antikörper)-dependent manner, independent of the classic mitotic kinase, Plk1.

  5. centrosome protein Dzip1 (zeige DZIP1 Antikörper) mediates the assembly of the BBSome-Dzip1 (zeige DZIP1 Antikörper)-PCM1 (zeige MBD1 Antikörper) complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome. Phosphorylation of Dzip1 (zeige DZIP1 Antikörper) at Ser (zeige SIGLEC1 Antikörper)-210 by Plk1 (polo-like kinase 1) during the G2 phase promotes disassembly of this complex, resulting in removal of Dzip1 (zeige DZIP1 Antikörper) and the BBSome from the CS.

  6. These findings suggest that Plk1 regulates smooth muscle contraction by modulating vimentin (zeige VIM Antikörper) phosphorylation at Ser (zeige SIGLEC1 Antikörper)-56.

  7. Results indicate that polo-like kinase 1 (PLK1) controls the onset of spindle assembly and spindle formation, and is essential for anaphase-promoting complex/cyclosome (APC (zeige APC Antikörper)/C) activation before anaphase onset in zygotes.

  8. observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

  9. Plk1 activity is required for meiotic spindle assembly and REC8 (zeige REC8 Antikörper) cleavage, with pPlk1Ser137 being the action executor, in mouse oocytes during meiotic division.

  10. Augmented expression of Aurora kinase-A (zeige AURKA Antikörper) and Polo-like kinase-1 at the lactogenic switch likely mediates the formation of binucleated cells.

Zebrafish Polo-Like Kinase 1 (PLK1) Interaktionspartner

  1. Report the 2.3-A crystal structure of the complex of the N-terminal kinase domain (KD) and a C-terminal Polo-box domain (PBD together with a PBD-binding motif of Drosophila melanogaster microtubule-associated protein (zeige FAM82A2 Antikörper) 205 (Map205(PBM)).

  2. Studies demonstrate that Plk1 is required for embryonic proliferation because its activity is crucial for mitotic integrity.

  3. for the first time that Plk1 can accommodate extended ATP-competitive compounds that project toward the adaptive pocket and help the enzyme order its activation segment

Caenorhabditis elegans (C. elegans) Polo-Like Kinase 1 (PLK1) Interaktionspartner

  1. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.

  2. Our data further show that PLK-1 is needed for nuclear envelope breakdown during early embryogenesis

  3. PLK-1 substitutes for Mps1 in controlling spindle checkpoint initiation in C. elegans.

  4. NCAPG2 (zeige NCAPG2 Antikörper) plays an important role in regulating proper chromosome segregation through a functional interaction with PLK1 during mitosis

  5. CDK-1 (zeige CDK1 Antikörper) activates PLK-1 via SPAT (zeige AGXT Antikörper)-1 phosphorylation to promote entry into mitosis.

  6. The result provide key insights into the regulation of homolog pairing and reveal that targeting of plk-1 to the NE by meiotic chromosomes establishes the conserved linkages to cytoskeletal forces needed for homology assessment.

  7. SPAT (zeige AGXT Antikörper)-1 and PLK-1 depletion causes impaired polarity with abnormal length of the anterior and posterior PAR (zeige AFG3L2 Antikörper) domains, and partial plk-1(RNAi) or spat (zeige AGXT Antikörper)-1(RNAi), but not air-1(RNAi), can rescue the lethality of a par-2 (zeige F2RL1 Antikörper) mutant.

  8. Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX (zeige ZSWIM2 Antikörper)-6.

  9. plk-1 asymmetry contributes to asynchronous cell division in C. elegans embryos.

  10. We suggest that control of Plk1 and Cdc25 (zeige CDC25C Antikörper) may be relevant to regulation of cell cycle length in other developmental contexts.

PLK1 Antigen-Profil

Beschreibung des Gens

human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis

Alternative names and synonyms associated with PLK1

  • polo-like kinase 1 (plk1) Antikörper
  • CG12306 gene product from transcript CG12306-RA (polo) Antikörper
  • polo-like kinase 1 (PLK1) Antikörper
  • polo-like kinase 1 (Plk1) Antikörper
  • polo-like kinase 1 (Drosophila) (plk1) Antikörper
  • polo-like kinase 2 (Plk2) Antikörper
  • Protein PLK-1 (plk-1) Antikörper
  • 0256/04 Antikörper
  • 1324/08 Antikörper
  • anon-WO0172774.3 Antikörper
  • cb525 Antikörper
  • cb636 Antikörper
  • CG12306 Antikörper
  • Dmel\CG12306 Antikörper
  • ik:tdsubc_2d1 Antikörper
  • l(3)01673 Antikörper
  • l(3)77Aa Antikörper
  • l(3)S025604 Antikörper
  • l(3)S132408 Antikörper
  • Plk Antikörper
  • PLK-1 Antikörper
  • PLK1 Antikörper
  • Plx1 Antikörper
  • Polo Antikörper
  • POLO/PLK1 Antikörper
  • Polo kinase Antikörper
  • Snk Antikörper
  • STPK13 Antikörper
  • wu:fb37g11 Antikörper
  • wu:fb76g03 Antikörper
  • xx:tdsubc_2d1 Antikörper

Bezeichner auf Proteinebene für PLK1

serine/threonine-protein kinase PLK1 , CG12306-PA , CG12306-PB , polo kinase , polo protein kinase , polo-PA , polo-PB , PLK-1 , plx1 , cell cycle regulated protein kinase , polo (Drosophia)-like kinase , polo like kinase , serine/threonine-protein kinase 13 , polo-like protein kinase , polo-like kinase homolog , PLK-2 , polo-like kinase 1 , serine/threonine-protein kinase PLK2 , serine/threonine-protein kinase SNK , serum-inducible kinase

GENE ID SPEZIES
407937 Xenopus (Silurana) tropicalis
40232 Drosophila melanogaster
380481 Xenopus laevis
416575 Gallus gallus
453991 Pan troglodytes
5347 Homo sapiens
489971 Canis lupus familiaris
396953 Sus scrofa
18817 Mus musculus
25515 Rattus norvegicus
538238 Bos taurus
280649 Danio rerio
83722 Rattus norvegicus
176143 Caenorhabditis elegans
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