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anti-Human MYT1 Antikörper:
anti-Mouse (Murine) MYT1 Antikörper:
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Human Polyclonal MYT1 Primary Antibody für ICC, IF - ABIN4337585
Chandrasekar, Dreyer: The brain-specific Neural Zinc Finger transcription factor 2b (NZF-2b/7ZFMyt1) causes suppression of cocaine-induced locomotor activity. in Neurobiology of disease 2009
Show all 3 Pubmed References
Human Polyclonal MYT1 Primary Antibody für DB, IHC (p) - ABIN389599
Mac?rek, Lindqvist, Lim, Lampson, Klompmaker, Freire, Clouin, Taylor, Yaffe, Medema: Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. in Nature 2008
although depletion of MYT1 alone did not affect long-term cell growth, it potentiated with DNA damage to inhibit cell growth in clonogenic survival and tumor xenograft models
These results suggesta potential role for Myt1 in the regeneration of oligodendrocyte lineage cells in response to demyelination.
UVA-induced caspase-3 (zeige CASP3 Antikörper) cleavage and DNA fragmentation were suppressed by the knockdown of human Myt1 in skin cancer cells.
NZF-1 was expressed later in post-mitotic neurons. NZF-2 was initially expressed in neuronal cells a little earlier than NZF-3. NZF-3 was initially expressed in neuronal cells, just after proliferation was complete.
MyT1 is a subunit of the neural cell type-specific LSD1 (zeige KDM1A Antikörper) complex.
used NMR spectroscopy, in combination with surface plasmon resonance and data-driven molecular docking, to delineate the mechanism of DNA binding for double zinc finger polypeptides derived from MyT1
These results suggest a potential role for Myt1 in the regeneration of oligodendrocyte lineage cells in response to demyelination.
in embryonic mouse nervous system, the expression of NZF (zeige PHF20 Antikörper)-2b starts as early as at 9.5 days post-coitum (dpc) in newly differentiated neurons in the central nervous system (CNS) and the peripheral nervous system (PNS)
Expression of Myt1 inhibited the differentiation of progenitors into oligodendrocytes as assessed by morphology, immunostaining, and myelin gene expression. Progenitor differentiation was similarly inhibited by expression of Myt1.
The Myt1 family of zinc finger proteins, when bound to a neural promoter, can recruit Sin3B (zeige SIN3B Antikörper). Depending on the relative availability of Sin3B (zeige SIN3B Antikörper) isoforms, the Myt1 gene family may favor the silencing of genes during neural development.
Myt1, Myt3, and Ngn3 (zeige NEUROG3 Antikörper) are induced by Mfng (zeige MFNG Antikörper) and have roles in Mfng (zeige MFNG Antikörper)-mediated repression of Notch (zeige NOTCH1 Antikörper) signaling which could serve as a trigger for endocrine islet differentiation
These findings suggest Myt1 is involved in proper endocrine differentiation and function.
MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.
myelin transcription factor 1
, myelin transcription factor I
, proteolipid protein binding protein
, proteolipid protein-binding protein
, neural zinc finger factor 2
, neural zinc finger transcription factor 2