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Human WNT3A Protein expressed in Wheat germ - ABIN1325361
Zhang, Han, Chen, Shi, Yang, Ren, Chen, Zhang, Pu, Kang: Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas. in Cancer letters 2013
These data define the mechanism responsible for the repressive effects of nitric oxide (NO) on the transcriptional activity of beta-catenin (zeige CTNNB1 Proteine) and link eNOS (zeige NOS3 Proteine)-derived NO to the modulation by VEGF (zeige VEGFA Proteine) of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)-induced endothelial cell proliferation.
These results indicate that PEDF (zeige SERPINF1 Proteine) counters Wnt (zeige WNT2 Proteine) signaling to allow for osteoblast differentiation and provides a mechanistic insight into how the PEDF (zeige SERPINF1 Proteine) null state results in OI type VI.
These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt (zeige NPNT Proteine) gene expression
this study shows that the Wnt3a expression levels in dendritic cells influences the generation of memory T cells after 5 days in co-culture with naive T cells through activation of the Wnt (zeige WNT2 Proteine) canonical pathway
Wnt3a induces Osx (zeige SP7 Proteine) expression via p38 MAPK (zeige MAPK14 Proteine) signaling in dental follicle cells. Wnt3a-induced Osx (zeige SP7 Proteine) expression was inhibited in the presence of p38 mitogen-activated protein kinase (zeige MAPK14 Proteine) (MAPK (zeige MAPK1 Proteine)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Furthermore, pigment epithelium-derived factor (PEDF (zeige SERPINF1 Proteine)), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2 (zeige SOD2 Proteine)) and catalase (zeige CAT Proteine).
Ginkgo biloba exocarp extract inhibits tumor angiogenesis, which may be closely relevant to its effect in blockage of Wnt /beta-catenin-VEGF signaling pathway in Lewis lung carcinoma.
Western blot analysis demonstrated that following BMP2 (zeige BMP2 Proteine) and BMP7 (zeige BMP7 Proteine) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (zeige BMP2 Proteine), BMP4 (zeige BMP4 Proteine), BMP6 (zeige BMP6 Proteine), BMP7 (zeige BMP7 Proteine), BMP9 (zeige GDF2 Proteine) and Wnt3a were increased compared with control cells
Wnt3a promotes macrophage-mediated bacterial killing by elevating CRAMP and BD1 (zeige DEFB1 Proteine) levels.
Wnt3a acutely reduces nuclear acetyl-CoA (zeige LPCAT1 Proteine), the necessary substrate for histone acetyltransferases, resulting in a global decrease in histone acetylation.
study reveals that Foxi1 (zeige FOXI1 Proteine)/miR (zeige MLXIP Proteine)-491-5p/Wnt3a/beta-catenin (zeige CTNNB1 Proteine) signaling is critical in the progression of GC. Targeting the pathway described in this study may open up new prospects to restrict the progression of gastric cancer
CHIR suppressed the hypertrophic propensity of the MSC (zeige MSC Proteine)-derived cartilage after in vivo implantation to an extent approaching that of WNT3A protein. These results indicate that CHIR may be a promising alternative for WNT3A protein for certain applications of human bone marrow-derived MSCs.
PEGylated Wnt3A liposomes associated with skeletal stem cell populations in human bone marrow and promoted osteogenesis.
The AChE plays a role in osteoblastic differentiation and is regulated by both Wnt3a and Runx2 (zeige RUNX2 Proteine).
In promoting the self-renewal symmetric division of hTERT(high) prostate cancer cells, WNT3a dramatically decreased the ratio of hTERT(high) prostate cancer cells undergoing asymmetric division. Increased WNT (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signal activation was also detected in hTERT(high) prostate cancer cells. hTERT-mediated CSC properties were at least partially dependent on beta-catenin (zeige CTNNB1 Proteine).
the results indicate neighboring structural elements within full-length Wnt3a affect saposin-like subdomain (SLD) conformational stability. Moreover, SLD function(s) in Wnt (zeige WNT2 Proteine) proteins appear to have evolved away from those commonly attributed to SAPLIP family members.
Data suggest that PORCN (zeige PORCN Proteine) exhibits substrate specificity that includes a Wnt3a peptide fragment (residues 199-219, with disulfide bonds); recombinant PORCN (zeige PORCN Proteine) containing a point mutation (R228C) associated with focal dermal hypoplasia exhibits impaired acylation activity toward Wnt3a peptide fragment. (PORCN (zeige PORCN Proteine) = porcupine (zeige PORCN Proteine) O-acyltransferase; Wnt3a = Wnt (zeige WNT2 Proteine) family member 3A)
CPE (zeige CPE Proteine) through its N'-terminal sequence, forms aggregates with Wnt3a and possible endoplasmic reticulum (ER) stress leading to its loss of function.
Our findings suggest that Pyk2 (zeige PTK2B Proteine) plays an important role in the coordination of stabilization of beta-catenin (zeige CTNNB1 Proteine) in the crosstalk between Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and Wnt (zeige WNT2 Proteine)/Ca(2 (zeige CA2 Proteine)+) signaling pathways upon Wnt3a stimulation in differentiating hNPCs.
Macrophage polarization seems to have a key role in the progression of pediatric non-alcoholic fatty liver disease; the modulation of macrophage polarization could drive hepatic progenitor cell response by Wnt3a production and beta-catenin (zeige CTNNB1 Proteine) phosphorylation.
Data suggest that Wnt3, Wnt3a, and Wnt8a (zeige WNT8A Proteine) bind to their respective receptors (Fz8 (zeige FZD2 Proteine), Lrp6 (zeige LRP5 Proteine), and Lypd6 (zeige LYPD6 Proteine)) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt (zeige WNT2 Proteine) proteins to their receptor complexes and stimulation of downstream signaling activity.
It was shown that Wnt3a-Wnt8a (zeige WNT8A Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle.
In zebrafish embryos lacking Wnt3a, Wnt1 (zeige WNT1 Proteine) and Wnt10b (zeige WNT10B Proteine), the expression of engrailed orthologs, pax2a and fgf8 (zeige FGF8 Proteine) is not maintained after mid-somitogenesis
data suggest a specific role for Wnt3a in the development of cardiac NCCs; propose that this function of wnt3a in r6 is partially mediated by crip2 (zeige CRIP2 Proteine) expression in the premigratory cardiac NCCs, which subsequently affects cardiac function and PA patterning
Sulf1 (zeige SULF1 Proteine) does not affect Wnt3a-mediated activation of canonical Wnt (zeige WNT2 Proteine) signaling.
Wnt3a protein alone is sufficient to rescue the severe loss of inner ear structures resulting from dorsal but not ventral half ablations.
hindbrain-repressive Wnt3a/Meis3/Tsh1 circuit promotes neuronal differentiation and coordinates tissue maturation
Wnt3a thus acts downstream of FAK (zeige PTK2 Proteine) to balance anterior-posterior cell fate specification in the developing neural plate
Data suggest a new model for neural anteroposterior patterning, in which Wnt3a from the paraxial mesoderm induces posterior cell fates via direct activation of a crucial transcription factor in the overlying neural plate.
Wnt3A secretion from tectal cells along with ephrin-B1 (zeige EFNB1 Proteine) signaling are specifically responsible for enhanced neural responses in the developing optic tectum.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.
wingless-type MMTV integration site family, member 3A
, protein Wnt-3a-like
, protein Wnt-3a
, vestigial tail
, wingless-type MMTV integration site family, member 3 like
, wnt3 like
, wingless-type MMTV integration site family, member 3
, Wnt-3a homolog
, Wnt3a variant 3
, wingless-type MMTV integration site family member 3a
, wingless-related MMTV integration site 3A