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anti-Human WIF1 Antikörper:
anti-Mouse (Murine) WIF1 Antikörper:
anti-Rat (Rattus) WIF1 Antikörper:
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Human Monoclonal WIF1 Primary Antibody für IF, IHC - ABIN967258
Veeck, Wild, Fuchs, Schüffler, Hartmann, Knüchel, Dahl: Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. in BMC cancer 2009
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Human Monoclonal WIF1 Primary Antibody für ICC, IHC - ABIN969457
Kawakami, Hirata, Yamamura, Kikuno, Saini, Majid, Tanaka, Kawamoto, Enokida, Nakagawa, Dahiya: Functional significance of Wnt inhibitory factor-1 gene in kidney cancer. in Cancer research 2009
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Human Polyclonal WIF1 Primary Antibody für IHC (p), WB - ABIN389184
Elston, Gill, Conaglen, Clarkson, Shaw, Law, Cook, Little, Clifton-Bligh, Robinson, McDonald: Wnt pathway inhibitors are strongly down-regulated in pituitary tumors. in Endocrinology 2008
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Study supported the hypothesis that Wnt inhibitory factor 1 (WIF1) is crucial as a negative regulator of the functions of endothelial cells in angiogenesis and that hypoxia plays an important role in controlling WIF1 expression and angiogenesis.
Our data suggests that total cellular b-catenin levels decrease in the presence of secreted frizzled-related protein 1 (zeige SFRP1 Antikörper) and Wnt inhibitory factor 1, and a significant increase in cell death after tyrosine kinase (zeige TXK Antikörper) inhibitor treatment is observed. On the contrary, when secreted frizzled-related protein 1 (zeige SFRP1 Antikörper) is suppressed, total b-catenin levels increase in the cell and the cells become resistant to tyrosine kinase (zeige TXK Antikörper) inhibitors.
Gallbladder cancer patients with hypermethylated WIF-1 exhibited worse overall survival than those with hypomethylated WIF-1.
In astrocytoma specimens, tumor areas with numerous single cells were identified which strongly express Wif-1.
Hypermethylation of WIF1 (WNT inhibitory factor 1) and NPY (neuropeptide Y (zeige NPY Antikörper)) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage.
the expression levels of WIF-1 were low in gallbladder cancer tumor tissues and the GBC-SD, SGC (zeige SGCB Antikörper)-996 and NOZ gallbladder cancer cell lines. This low expression was associated with the methylation status of the WIF-1 gene promotor.
Compared with adjacent normal tissues, the methylation frequencies of WIF-1, RASSF1A (zeige RASSF1 Antikörper), and CDH13 (zeige CDH13 Antikörper) genes were significantly higher but the mRNA levels of these 3 genes were significantly lower in EC tissues. The survival rates of patients with WIF-1, RASSF1A (zeige RASSF1 Antikörper), and CDH13 (zeige CDH13 Antikörper) methylations were significantly lower than those of patients without methylation
Promoter hypermethylation WIF1 play an important role in the carcinogenesis of lung cancer.
HOTAIR can affect the radiosensitivity of pancreatic ductal adenocarcinoma (PDAC) cells partly via regulating the expression of WIF-1, and HOTAIR-WIF-1 axis is a potential target for PDAC radiotherapy.
beta-catenin (zeige CTNNB1 Antikörper) expression may also be a poor prognostic factor for cervical cancer (CC) while WIF1 could be a potential drug target for treatment of advanced CC.
Wif1 localizes to the enamel knot (zeige KCNK7 Antikörper) in which Wif1 regulates apoptosis by mediating and regulating Wnt (zeige WNT2 Antikörper)-beta-catenin (zeige CTNNB1 Antikörper) signaling. Thus, Wif1 plays an essential role in tooth development.
WIF1 has a role in breast neoplasms: its inhibition significantly relieves the cancer stem cell-limiting effects of dietary compound isoliquiritigenin
results demonstrate that Wif1 is not targeted for silencing by DNA methylation (zeige HELLS Antikörper) in OS. Instead, the reduced expression of Wif1 in OS cells is in context with their stage in differentiation
EZH2 (zeige EZH2 Antikörper)-induced downregulation of WIF1 expression may partially regulate Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper)-dependent crypt hyperplasia in response to citrobacter rodentium infection
Dysregulation of this endodermal Shh-Wif1-b-catenin signaling axis contributes to ARM pathogenesis.
It is anticipated that our findings will contribute to expansion of our understanding of WIF1 biological function on heart development and possible modes of treatment of heart diseases
WIF1 secretion by the Mullerian duct mesenchyme plays a role in Mullerian duct regression in fetal males
These data suggest that WIF-1 may take part in the fine-tuning of cartilage and bone turnover, promoting the balance of cartilage versus bone anabolism.
Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development
Osteoblastic Wif1 overexpression disrupts stem cell quiescence, leading to a loss of self-renewal potential.
In an examination of signaling pathways in developing Xenopus lung, wif1 was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Data describe the importance of proper level of Wnt (zeige WNT2 Antikörper) signaling for normal development of swimbladder in Wif1 morphant zebrafish.
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers.
, wnt inhibitory factor 1
, WNT inhibitory factor 1
, wnt inhibitory factor 1-like
, Wnt inhibitory factor-1
, wnt inhibitory factor-1