anti-GSK3 beta (GSK3b) Antikörper

Bezeichnung:
anti-Glycogen Synthase Kinase 3 beta Antikörper (GSK3b)
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Synonyme:
7330414F15Rik, 8430431H08Rik, C86142, fk80d11, gsk-3, GSK-3beta, GSK-3[b], gsk3, gsk3-beta, GSK3beta, wu:fb68h05, wu:fk80d11, xgsk-3
Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Maus GSK3b GSK3b 56637 Q9WV60
Anti-Ratte GSK3b GSK3b 84027 P18266
Anti-Human GSK3b GSK3b 2932 P49841

Weitere Synonyme anzeigen

Weitere Antikörper gegen GSK3 beta Interaktionspartner

Mouse (Murine) Glycogen Synthase Kinase 3 beta (GSK3b) Interaktionspartner

  1. changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine (zeige CX3CL1 Antikörper), a chemokine (zeige CCL1 Antikörper) involved in the immune response that has been linked to AD and to other different neurological disorders.

  2. The activation of brain GSK-3beta expression is increased in an animal model of depressive syndrome.

  3. Findings suggest that atorvastatin attenuates diabetes-associated renal injury by reducing reactive oxygen species (ROS (zeige ROS1 Antikörper)) generation, RhoA (zeige RHOA Antikörper) activity and normalizing Akt (zeige AKT1 Antikörper)/GSK3beta signaling pathways.

  4. Tregs ameliorated ICH (zeige ACE Antikörper)-induced inflammatory injury by modulating microglia/macrophage polarization toward the M2 phenotype through the IL-10 (zeige IL10 Antikörper)/GSK3beta/PTEN (zeige PTEN Antikörper) axis

  5. GSK-3beta(+/-) mouse hearts exhibited more severe hypertrophy, which was characterized by accelerated interstitial fibrosis, than wild-type mouse hearts after transverse aortic constriction, suggesting that reduced GSK-3beta activity aggravates pressure-induced left ventricular remodeling.

  6. findings indicate a previously unknown interaction between GSK3beta and ELAV-1 (zeige ELAVL1 Antikörper) during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1 (zeige ELAVL1 Antikörper)- GSK3beta pathways as a novel acute respiratory distress syndrome treatment approach.

  7. data suggest GSK3b and mTOR (zeige FRAP1 Antikörper) pathways modulate this ATXN1 (zeige ATXN1 Antikörper) function in spinocerebellar ataxia (zeige USP14 Antikörper) type-1 (SCA1 (zeige ATXN1 Antikörper))pathogenesis that could be targeted therapeutically prior to the onset of disease symptoms in SCA1 (zeige ATXN1 Antikörper) and other pathologies involving dysregulation of ATXN1 (zeige ATXN1 Antikörper) functions.

  8. GSK3 is regulated through mechanisms independent of N-terminal serine phosphorylation in order for beta-catenin (zeige CTNNB1 Antikörper) to be stabilized.

  9. This study suggests that the inhibition of GSK-3beta is cardioprotective in familial dilated cardiomyopathy associated with DeltaK210 cardiac troponin T (zeige TNNT2 Antikörper) mutation.

  10. Data show that the fine control of excitatory transmission by glycogen synthase kinase 3 (zeige GSK3a Antikörper) requires recruitment of dopamine D2-receptors and depends on the presence of serotonin 5-HT1A (zeige HTR1A Antikörper)-receptors.

Human Glycogen Synthase Kinase 3 beta (GSK3b) Interaktionspartner

  1. our findings identify the miR (zeige MLXIP Antikörper)-410/Gsk3beta/beta-catenin (zeige CTNNB1 Antikörper) signaling axis is a novel molecular circuit in inducing stemness of non-small cells lung cancer

  2. NOR1 (zeige NR4A3 Antikörper) suppresses cancer stem-like cell properties in nasopharyngeal carcinoma cells by inhibiting the AKT (zeige AKT1 Antikörper)-GSK-3beta-Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper)-ALDH1A1 (zeige ALDH1A1 Antikörper) signaling circuit.

  3. Studies show strong evidence supporting the idea that the hyperactive nutrient sensor GSK3beta plays a pivotal role in preserving quiescent hematopoietic stem cells despite its negative effects on self-renewal. [review]

  4. BMI1 (zeige BMI1 Antikörper) is a downstream target of GSK3 signaling.

  5. These findings suggest that the upregulation of Snail (zeige SNAI1 Antikörper) expression induced by H. pylori and transformation to a spindle-like shape as a consequence in gastric cancer cells are attributable to reactive oxygen species - mediated activation of Erk (zeige EPHB2 Antikörper) and the inactivation of GSK-3beta.

  6. changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine (zeige CX3CL1 Antikörper), a chemokine (zeige CCL1 Antikörper) involved in the immune response that has been linked to AD and to other different neurological disorders.

  7. Data indicate that microRNA miR (zeige MLXIP Antikörper)-27a directly targets GSK-3beta and increases expression of beta-catenin (zeige CTNNB1 Antikörper) and LEF1 (zeige LEF1 Antikörper) in all-trans-retinoic acid (ATRA)-induced Hep2 cells.

  8. Data indicate that microRNA miR (zeige MLXIP Antikörper)-744 activated Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway by targeting multiple negative regulators of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling, including SFRP1 (zeige SFRP1 Antikörper), GSK3beta, TLE3 and NKD1 (zeige NKD1 Antikörper), and that NKD1 (zeige NKD1 Antikörper) is a major functional target of miR (zeige MLXIP Antikörper)-744.

  9. this study shows that cross-talk between LFA-1 (zeige ITGAL Antikörper) and Notch1 (zeige NOTCH1 Antikörper) through the Akt (zeige AKT1 Antikörper)/ERK (zeige EPHB2 Antikörper)-GSK3beta signaling enhances T cell differentiation toward Th1 (zeige TH1L Antikörper)

  10. SGK1 (zeige SGK1 Antikörper) promotes YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) transcriptional activity. SGK1 (zeige SGK1 Antikörper) enhances YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) activity by upregulating YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper). SGK1 (zeige SGK1 Antikörper) is a transcriptional target of YAP (zeige YAP1 Antikörper). SGK1 (zeige SGK1 Antikörper) stabilizes TAZ (zeige TAZ Antikörper) by inhibiting GSK3beta.

Xenopus laevis Glycogen Synthase Kinase 3 beta (GSK3b) Interaktionspartner

  1. Novel roles for Plk (zeige PLK1 Antikörper) and GSK3 regulation of ADAM13 (zeige ADAM33 Antikörper) function in cranial neural crest cell migration.

  2. Interaction with Snail1 (zeige SNAI1 Antikörper)/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.

  3. These data suggest that the interactions of beta-catenin (zeige CTNNB1 Antikörper) with alpha-catenin (zeige CTNNA1 Antikörper) and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.

Zebrafish Glycogen Synthase Kinase 3 beta (GSK3b) Interaktionspartner

  1. Both active and inactive forms of Gsk3b mediate the cooperative signaling during angiogenesis in zebrafish embryos.

  2. a novel negative, Gsk3beta-independent control mechanism of beta-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation.

  3. The regulatory target of Wnts and Igfs, GSK3beta, is inefficiently inactivated in male fin regenerates compared with females. Pharmacological inhibition of GSK3 in males increases blastemal proliferation and restores regenerative pattern.

  4. 2-OST (zeige HS2ST1 Antikörper) functions within the Wnt (zeige WNT2 Antikörper) pathway, downstream of Wnt (zeige WNT2 Antikörper) ligand signaling and upstream of Gsk3beta and beta-catenin (zeige CTNNB1 Antikörper) intracellular localization and function

  5. Data show that GSK-3beta inhibition was sufficient to stimulate MG dedifferentiation and the formation of multipotent retinal progenitors that were capable of differentiating into all major retinal cell types.

  6. GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival

  7. Gsk3b regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (zeige SGPL1 Antikörper)) factor activity.

  8. A newly developed highly active GSK3beta inhibitor AR-534, reduced human TAU phosphorylation in TAU transgenic zebrafish.

Pig (Porcine) Glycogen Synthase Kinase 3 beta (GSK3b) Interaktionspartner

  1. Five different isoforms of GSK3beta identified from porcine tissues, splice variants exhibit differential activity towards glycogen synthase.

  2. scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of GSK3beta activity which can lead to activation of the downstream signaling through beta-catenin (zeige CTNNB1 Antikörper)

  3. There was no correlation of infarct size with expression or phosphorylation of p70S6K (zeige RPS6KB1 Antikörper) or GSK3beta in ischemic postconditioning.

Cow (Bovine) Glycogen Synthase Kinase 3 beta (GSK3b) Interaktionspartner

  1. GSK3B and phosphorylated GSK3B regulate milk synthesis and proliferation dairy cow mammary epithelial cells.

  2. GSK3B serine phosphorylation was positively correlated with embryo development

  3. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

  4. IGF-I (zeige IGF1 Antikörper) down-regulated functional IGF-I receptor (zeige IGF1R Antikörper) via GSK-3beta inhibition and mTOR (zeige FRAP1 Antikörper) activation; constitutive activity of GSK-3beta maintained IGF-I receptor (zeige IGF1R Antikörper) level in nonstimulated cells.

  5. These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated phosphorylation of SH-binding proteins, including MBP (zeige MBP Antikörper) and tau protein.

  6. cAMP/PKA regulation of GSK3beta/beta-catenin (zeige CTNNB1 Antikörper) signaling contributes to the increase in progesterone production in corpus luteum.

GSK3 beta (GSK3b) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GSK3 beta (GSK3b)

  • glycogen synthase kinase 3 beta (Gsk3b) Antikörper
  • glycogen synthase kinase 3 beta (GSK3B) Antikörper
  • glycogen synthase kinase 3 beta (gsk3b) Antikörper
  • 7330414F15Rik Antikörper
  • 8430431H08Rik Antikörper
  • C86142 Antikörper
  • fk80d11 Antikörper
  • gsk-3 Antikörper
  • GSK-3beta Antikörper
  • GSK-3[b] Antikörper
  • gsk3 Antikörper
  • gsk3-beta Antikörper
  • GSK3beta Antikörper
  • wu:fb68h05 Antikörper
  • wu:fk80d11 Antikörper
  • xgsk-3 Antikörper

Bezeichner auf Proteinebene für GSK3b

GSK-3 beta , glycogen synthase kinase-3 beta , serine/threonine-protein kinase GSK3B , FA , factor A , GSK3beta isoform , intracellular kinase , fb68h05 , glycogen synthase kinase 3 beta variant 1 , glycogen synthase kinase 3 beta variant 2 , glycogen synthase kinase 3 beta variant 3 , glycogen synthase kinase 3 beta variant 4 , GSK-3beta

GENE ID SPEZIES
56637 Mus musculus
84027 Rattus norvegicus
2932 Homo sapiens
399097 Xenopus laevis
30654 Danio rerio
478575 Canis lupus familiaris
100126852 Sus scrofa
790875 Bos taurus
418335 Gallus gallus
100348842 Oryctolagus cuniculus
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