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Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Zeige alle 6 Referenzen für 2004177
Mouse (Murine) CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2008021
Butz, Kemler: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. in FEBS letters 1995
Zeige alle 5 Referenzen für 2008021
Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
TIEG1 is involved in regulating the canonical Wnt (zeige WNT2 Proteine) signaling pathway in bone through multiple mechanisms of action.
Activation of WNT/b-catenin activity improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH222P/H222P mice, which was associated with increased expression of myocardial connexin 43. These results indicate that decreased WNT/b-catenin contributes to the pathophysiology of LMNA cardiomyopathy and that drugs activating b-catenin may be beneficial in affected individuals
Oncogenic beta-catenin and PI3K activities interact in the acquisition of multiple cancer-related phenotypes in organoids grown in Matrigel.
We further found that knockdown of Kif2a (zeige KIF2A Proteine) decreased the protein level of b-catenin, which is a critical molecule for neocortical neurogenesis. Together, these results reveal an important function of Kif2a (zeige KIF2A Proteine) in embryonic neocortical neurogenesis
Data show that both Wnt1 (zeige WNT1 Proteine)-cre and P0-cre are similarly effective in deleting beta-catenin in the neural crest.
HIRA (zeige HIRA Proteine), in cooperation with Setd1A, modulates beta-catenin expression to regulate neural stem cell proliferation and neurogenesis.
Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
cadherin 2 (CDH2 (zeige CDH2 Proteine)) and CDH4 (zeige CDH4 Proteine) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B (zeige PTPN1 Proteine)) and alpha- and beta-catenins.
Postnatal beta-catenin ablation in fibroblasts promoted hair follicle (HF) regeneration in neonatal and adult mouse wounds, whereas beta-catenin activation reduced HF regeneration in neonatal wounds.
In the absence of the zona pellucida, embryos lacking CTNNB1 undergo fission and these separated blastomeres can become small trophoblastic vesicles, which in turn induce decidual reactions.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (zeige WNT2 Proteine) pathway, therefore suggesting a possible role for Wnt (zeige WNT2 Proteine) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (zeige MYLIP Proteine)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (zeige WNT2 Proteine) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (zeige WNT2 Proteine)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt (zeige WNT2 Proteine) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (zeige WNT2 Proteine) signaling subsequently controls the fate of the progeny of those cell divisions.
A novel role for Eaf1 (zeige EAF1 Proteine) and Eaf2 (zeige EAF2 Proteine) in inhibiting canonical Wnt (zeige WNT2 Proteine)/beta-catenin signaling, which might form the mechanistic basis for Eaf1 (zeige EAF1 Proteine) and Eaf2 (zeige EAF2 Proteine) tumor suppressor activity.
Ccr7 (zeige CCR7 Proteine) functions during axis formation as a GPCR to inhibit beta-catenin, likely by promoting Ca(2 (zeige CA2 Proteine)+) transients throughout the blastula.
ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (zeige PPP2R2B Proteine) and thereby down-regulating the Wnt (zeige WNT2 Proteine)/beta-catenin signaling.
maternal Wnt (zeige WNT2 Proteine)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (zeige WNT2 Proteine) signalling can benefit from nucleo-cytoplasmic shuttling of APC (zeige APC Proteine), Axin (zeige AXIN1 Proteine) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (zeige AKT1 Proteine) polarization depend specifically on the N-cadherin (zeige CDH2 Proteine)-p120 catenin (zeige CTNND1 Proteine) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (zeige CDH2 Proteine)-beta-catenin complex.
HERG (zeige KCNH2 Proteine) channel activity is stimulated by beta-catenin
Zic3 (zeige ZIC3 Proteine) can suppress Wnt (zeige WNT2 Proteine)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (zeige KDR Proteine), PTK7 (zeige PTK7 Proteine), is implicated in beta-catenin-dependent developmental processes.
Kazrin (zeige KAZ Proteine) interacts with ARVCF (zeige ARVCF Proteine)-catenin, spectrin and p190B RhoGAP (zeige ARHGAP1 Proteine), and modulates RhoA (zeige RHOA Proteine) activity.
our findings identify the miR (zeige MLXIP Proteine)-410/Gsk3beta/beta-catenin signaling axis is a novel molecular circuit in inducing stemness of non-small cells lung cancer
NOR1 (zeige NR4A3 Proteine) suppresses cancer stem-like cell properties in nasopharyngeal carcinoma cells by inhibiting the AKT (zeige AKT1 Proteine)-GSK-3beta-Wnt (zeige WNT2 Proteine)/beta-catenin-ALDH1A1 (zeige ALDH1A1 Proteine) signaling circuit.
Data suggest that DBC1 (zeige DBC1 Proteine) has a dual function in regulating beta-catenin-PROX1 (zeige PROX1 Proteine) signaling axis: as a coactivator for both beta-catenin and PROX1 (zeige PROX1 Proteine).
Indicate that beta-catenin and SATB2 (zeige SATB2 Proteine) are useful immunohistochemical markers for differentiating between pulmonary enteric adenocarcinoma and metastatic colorectal carcinoma.
In promoting the self-renewal symmetric division of hTERT(high) prostate cancer cells, WNT3a (zeige WNT3A Proteine) dramatically decreased the ratio of hTERT(high) prostate cancer cells undergoing asymmetric division. Increased WNT (zeige WNT2 Proteine)/beta-catenin signal activation was also detected in hTERT(high) prostate cancer cells. hTERT-mediated CSC properties were at least partially dependent on beta-catenin.
These data define the mechanism responsible for the repressive effects of nitric oxide (NO) on the transcriptional activity of beta-catenin and link eNOS (zeige NOS3 Proteine)-derived NO to the modulation by VEGF (zeige VEGFA Proteine) of Wnt (zeige WNT2 Proteine)/beta-catenin-induced endothelial cell proliferation.
Mutation in CTNNB1 gene is associated with Pancreatic Ductal Adenocarcinoma.
Lung allografts in bronchiolitis obliterans syndrome, demonstrated reduced beta-catenin transcriptional activation in the presence of LPA1 (zeige LPAR1 Proteine) antagonist, confirming an in vivo role for lysophosphatidic acid signaling in beta-catenin activation.
beta-catenin is a key mediator of P. falciparum adverse effects on endothelial integrity.
GLI2 is a regulator of beta-catenin and provides insights into its role in tumorigenesis.
Results highlight a potential role for the beta-catenin/Wnt (zeige WNT2 Proteine) and Notch (zeige NOTCH1 Proteine) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (zeige WNT3A Proteine) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (zeige TGFB1 Proteine)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (zeige WNT3A Proteine) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (zeige WNT2 Proteine)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (zeige TNF Proteine) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (zeige AKT1 Proteine) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (zeige BRD2 Proteine) regulates CTNNB1 protein and WNT2 (zeige WNT2 Proteine) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (zeige WNT2 Proteine) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (zeige PDZK1IP1 Proteine) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (zeige TGFB3 Proteine) induces the chondrogenic differentiation of pericytes by inducing Wnt (zeige WNT2 Proteine)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (zeige WNT2 Proteine)/beta-catenin and Hedgehog (zeige SHH Proteine) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin