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Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 Pubmed References
Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Results indicate that ablation of epithelial Wnt (zeige WNT2 Proteine)/beta-catenin signaling affected epididymal epithelial cell proliferation but did not inhibit cell differentiation.
Interactions between the Wnt (zeige WNT2 Proteine)/beta-catenin and the Kras/ERK (zeige EPHB2 Proteine)/Foxm1 (zeige FOXM1 Proteine) pathways are essential to restrict SOX9 (zeige SOX9 Proteine) expression in basal cells during pulmonary branching morphogenesis
The collective results indicate that the osteoanabolic response to loading can occur on the periosteal surface when beta-cat levels are significantly reduced in Dmp1 (zeige DMP1 Proteine)-expressing cells.
L. donovani triggered AKT (zeige AKT1 Proteine) activation to regulate GSK-3beta/beta-catenin/FOXO-1 (zeige FOXO1 Proteine) axis.
Barx2 (zeige BARX2 Proteine) and Pax7 (zeige PAX7 Proteine) regulate the canonical Wnt (zeige WNT2 Proteine) target gene Axin2 (zeige AXIN2 Proteine), which mediates critical feedback to terminate the transcriptional response to Wnt (zeige WNT2 Proteine) signals.
NFkB/beta-catenin signaling pathway plays a key role in the regulation of breast cancer-induced bone cell activity and osteolysis.
Knockdown of MACF1 (zeige MACF1 Proteine) in osteoblastic cells inhibits osteoblast differentiation through suppressing the beta-catenin/TCF1 (zeige HNF1A Proteine)-Runx2 (zeige RUNX2 Proteine) axis.
Transcriptional cofactors Bcl9 (zeige BCL9 Proteine), Bcl9l (zeige BCL9L Proteine) and Pygo1 (zeige PYGO1 Proteine)/2 act independently of beta-catenin to ensure proper enamel formation.
Transient expression of WNT2 (zeige WNT2 Proteine) promotes somatic cell reprogramming by inducing beta-catenin nuclear accumulation.
Beta-catenin regulates expression of downstream targets of a key transcriptional memory gene, Hoxa9 (zeige HOXA9 Proteine) that is highly enriched in myeloid leukemia (zeige BCL11A Proteine) cancer stem cells and helps sustain leukemic self-renewal.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (zeige WNT2 Proteine)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (zeige WNT2 Proteine) pathway, therefore suggesting a possible role for Wnt (zeige WNT2 Proteine) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (zeige MYLIP Proteine)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (zeige WNT2 Proteine) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (zeige WNT2 Proteine)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt (zeige WNT2 Proteine) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (zeige WNT2 Proteine) signaling subsequently controls the fate of the progeny of those cell divisions.
A novel role for Eaf1 (zeige EAF1 Proteine) and Eaf2 (zeige EAF2 Proteine) in inhibiting canonical Wnt (zeige WNT2 Proteine)/beta-catenin signaling, which might form the mechanistic basis for Eaf1 (zeige EAF1 Proteine) and Eaf2 (zeige EAF2 Proteine) tumor suppressor activity.
We identified the amphibian leap2 (zeige LEAP2 Proteine) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (zeige PPP2R2B Proteine) and thereby down-regulating the Wnt (zeige WNT2 Proteine)/beta-catenin signaling.
maternal Wnt (zeige WNT2 Proteine)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (zeige WNT2 Proteine) signalling can benefit from nucleo-cytoplasmic shuttling of APC (zeige APC Proteine), Axin (zeige AXIN1 Proteine) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (zeige AKT1 Proteine) polarization depend specifically on the N-cadherin (zeige CDH2 Proteine)-p120 catenin (zeige CTNND1 Proteine) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (zeige CDH2 Proteine)-beta-catenin complex.
HERG (zeige KCNH2 Proteine) channel activity is stimulated by beta-catenin
Zic3 (zeige ZIC3 Proteine) can suppress Wnt (zeige WNT2 Proteine)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (zeige KDR Proteine), PTK7 (zeige PTK7 Proteine), is implicated in beta-catenin-dependent developmental processes.
Data show that TRIM29 (zeige TRIM29 Proteine) promotes tumor progression by activating Wnt (zeige WNT2 Proteine)/beta-Catenin signaling.
High CTNNB1 expression is associated with colorectal cancer.
CTNNB1 and Wnts have roles in differentiation of pluripotent cells into profibrotic fibroblasts; C-82 has potential with longer treatment to promote fat regeneration in systemic sclerosis skin
Data indicate significant correlation of granulin-epithelin (zeige GRN Proteine) precursor (GEP) with beta-catenin in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cohort.
Diabetic Glc also promoted beta-catenin nuclear localization and the formation of a complex with FOXO3a (zeige FOXO3 Proteine) that localized to the promoters of Sod2 (zeige SOD2 Proteine), p21(cip1 (zeige CDKN1A Proteine)), and potentially p27(kip1 (zeige CDKN1B Proteine))
Solid pseudopapillary neoplasms (SPNs) showed positive staining for SRY (zeige SRY Proteine)-related high-mobility group box (zeige SSRP1 Proteine) 11 (SOX-11 (zeige SOX11 Proteine)), transcription factor E3 (TFE3 (zeige TFE3 Proteine)) and beta-catenin on cell blocks.
H19 may regulate non-small cell lung cancer (NSCLC) metastasis through modulating cellular signaling pathway proteins related to cell proliferation and cell adhesion, including MACC1, EGFR, beta-catenin and ERK1/2.
A positive feedback loop involving the Wnt/beta-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subset in ALK + anaplastic large cell lymphoma.
Results indicate that AQP3 (zeige AQP3 Proteine) promotes stem-like properties of gastric carcinoma (GC) cells by activating the Wnt (zeige WNT2 Proteine)/GSK-3beta/beta-catenin signaling pathway.
Results highlight a potential role for the beta-catenin/Wnt (zeige WNT2 Proteine) and Notch (zeige NOTCH1 Proteine) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (zeige WNT3A Proteine) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (zeige TGFB1 Proteine)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (zeige WNT3A Proteine) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (zeige WNT2 Proteine)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (zeige TNF Proteine) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (zeige AKT1 Proteine) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (zeige BRD2 Proteine) regulates CTNNB1 protein and WNT2 (zeige WNT2 Proteine) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (zeige WNT2 Proteine) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (zeige PDZK1IP1 Proteine) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (zeige TGFB3 Proteine) induces the chondrogenic differentiation of pericytes by inducing Wnt (zeige WNT2 Proteine)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (zeige WNT2 Proteine)/beta-catenin and Hedgehog (zeige SHH Proteine) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin