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we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Expected genes in the Scar-Arp2 (zeige ACTR2 ELISA Kits)/3 actin (zeige ACTB ELISA Kits) nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.
CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser (zeige SIGLEC1 ELISA Kits) and Thr (zeige TRH ELISA Kits) residues in the N-terminus and targeting it for degradation.
2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways
expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII (zeige CSNK2A1 ELISA Kits) kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta (zeige GSK3b ELISA Kits) in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
Maintenance of the progenitors thus requires cooperation by PRMT1 (zeige PRMT1 ELISA Kits) and CSNK1a1 to sustain proliferation gene expression and suppress premature differentiation driven by GRHL3 (zeige GRHL3 ELISA Kits)
These data indicate that CK1alpha has a dominant and non-redundant function in melanoma cells
KRT1 and the specific polymorphism of KRT1 in this Chinese Han population are associated with autoimmune diseases SLE and SSc (zeige CYP11A1 ELISA Kits)
Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2 (zeige MDM2 ELISA Kits), increased p53 (zeige TP53 ELISA Kits) and p21 (zeige CDKN1A ELISA Kits) and reduced expression of beta-catenin (zeige CTNNB1 ELISA Kits) and AKT (zeige AKT1 ELISA Kits).
CK1delta enhances EPO (zeige EPO ELISA Kits) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (zeige EPAS1 ELISA Kits) and promoting its nuclear accumulation.
CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII (zeige CAMK2G ELISA Kits) gamma and delta may have negative roles in the HCV life cycle.
Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis (zeige LBR ELISA Kits).
KRT1 played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease.
Report genetic/clinical spectrum of KRT1 mutations in keratinopathic ichthyosis (zeige LBR ELISA Kits).
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
Phosphorylation of LRRK2 (zeige LRRK2 ELISA Kits) by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7 (zeige ARHGEF7 ELISA Kits).
Phosphorylation of FADD (zeige FADD ELISA Kits) by the kinase CK1alpha promotes KRASG12D-induced lung cancer.
Csnk1a1 knockdown results in decreased Rps6 (zeige RPS6 ELISA Kits) phosphorylation, increased p53 (zeige TP53 ELISA Kits) activity, and myeloid differentiation.
study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development
Silencing or deleting the p53 (zeige TP53 ELISA Kits) gene demonstrated that genotoxic stress elicited Wnt (zeige WNT2 ELISA Kits) signaling in a p53 (zeige TP53 ELISA Kits)-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin (zeige CTNNB1 ELISA Kits).
maintenance of intestinal homeostasis in CKIalpha-deficient gut (zeige GUSB ELISA Kits) requires p53 (zeige TP53 ELISA Kits)-mediated growth control, because the combined ablation of Csnk1a1 and either p53 (zeige TP53 ELISA Kits) or its target gene p21 triggered high-grade dysplasia with extensive proliferation
Casein kinase I (zeige CSNK1D ELISA Kits) and casein kinase II (zeige CSNK2A1 ELISA Kits) differentially regulate axin (zeige AXIN1 ELISA Kits) function
CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C
CK1 regulates fast synaptic transmission by glutamate (zeige GRIN1 ELISA Kits) in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 (zeige PPP1CB ELISA Kits) &/or 2A & increased dephosphorylation of NMDA receptors.
Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.
The phosphorylation of p53 (zeige TP53 ELISA Kits) by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.
data provide a molecular insight into the structural features that underlie the site specificity of CK1a
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.
, casein kinase I isoform alpha
, clock regulator kinase
, down-regulated in lung cancer
, casein kinase I-alpha
, casein kinase I alpha LS
, protein kinase CK1 (casein kinase 1) isoform alpha
, casein kinase 1 alpha
, caesin kinase I alpha
, casein kinase 1
, casein kinase 1a
, casein kinase 1alpha
, casein kinase I
, casein kinase ialpha