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Redox-sensitive activation of p38 MAPK (zeige MAPK14 Proteine)/HSP27 (zeige HSPB1 Proteine) pathway or ERK1/2 in endothelial cells requires CaMKII
Destabilization of PGC1a is attributable to decreased p38 MAPK (zeige MAPK14 Proteine) activation via diminished CaMKII signaling. Thus, we elucidate a pathway downstream of Ca(2 (zeige CA2 Proteine)+)-mediated CaMKII activation that is dysfunctional in C3KO(Capn3 (zeige CAPN3 Proteine) knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation
A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC (zeige SLC25A20 Proteine)) development, thereby providing a potential new therapeutic target for CAC (zeige SLC25A20 Proteine).
In young mice, 30% of adult CaMKIIalpha expression is sufficient for normal long-term potentiation in the hippocampus and cerebral cortex.
Findings demonstrate that Thr286 phosphorylation of CaMKII plays an important role in induction of long-term potentiation (LTP (zeige SCP2 Proteine)) by integrating Ca(2 (zeige CA2 Proteine)+) signals, and it greatly promotes, but is dispensable for, the activation of CaMKII and LTP (zeige SCP2 Proteine).
The present study demonstrates, for the first time, that ROS (zeige ROS1 Proteine)-dependent activation of CaMKII mediates altered Ca2 (zeige CA2 Proteine)+ handling and contractile dysfunction observed in the setting of sepsis.
Thus, taken into consideration the mechanism that controls the upregulation of maturation genes involved in synaptic formation, these results indicate that Etv1 (zeige ETV1 Proteine) orchestrates the activity-dependent regulation of both maturation and immaturation genes in developing granule cells and plays a key role in specifying the identity of mature granule cells in the cerebellum.
Pharmacological and genetic studies using CaMKII antagonists and genetically modified [alpha]-CaMKII mice have shown that blockade or reduction of CaMKII reduces nicotine reward
The study shows advanced glycation end products (AGEs) resulted from ribosylation activate calcium-/calmodulin-dependent protein kinase type II (CaMKII), a key kinase responsible for Tau hyperphosphorylation.
HDAC2 (zeige HDAC2 Proteine) may regulate the expression of immediate early (zeige JUN Proteine) genes, in part, by prolonging the actions of pCREB in the mouse nucleus accumbens.
The results suggest that CaMKII-dependent TnI (zeige TNNI2 Proteine) phosphorylation is involved in FDMCD and the consequent FDAR and that CaMKII inhibition removes this mechanism and thus induces diastolic dysfunction.
A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC (zeige CA2 Proteine)) development, thereby providing a potential new therapeutic target for CAC (zeige CA2 Proteine).
oxidative stress activated the TRPM2 (zeige CLU Proteine)-CaMKII cascade to further induce intracellular ROS (zeige ROS1 Proteine) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential
CKIalpha (zeige CSNK1A1 Proteine)-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII gamma and delta may have negative roles in the HCV life cycle.
Demonstrate that calcium/CaMKIIgamma/AKT (zeige AKT1 Proteine) signaling can regulate apoptosis and autophagy simultaneously in colorectal cancer cells.
Dysfunction in CaMKII-based signaling has been linked with a host of cardiovascular phenotypes including heart failure and arrhythmia, and CaMKII levels are elevated in human and animal disease models of heart disease.
Inhibition of CaMKII activity results in an upregulation of CaMKIV (zeige CAMK4 Proteine) mRNA and protein in leukemia cell lines.
CAMKIIgamma, HSP70 (zeige HSP70 Proteine) and HSP90 (zeige HSP90 Proteine) transcripts are differentially expressed in chronic myeloid leukemia (zeige BCL11A Proteine) cells from patients with resistant mutated disease.
CaMKII-dependent microtube polymerization may be responsible for the enhanced uptake of PEI/ON complexes in A549 cells under oxidative stress conditions.
Our data suggest that berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII
CaMKII overexpression in mushroom body neurons increases activity dependent calcium responses.
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
, calcium/calmodulin-dependent protein kinase type II subunit gamma
, calcium/calmodulin-dependent protein kinase II beta
, calcium/calmodulin-dependent protein kinase II gamma
, CaMK II
, caM kinase II subunit alpha
, caMK-II subunit alpha
, calcium/calmodulin-dependent protein kinase type II subunit alpha
, caMK-II subunit gamma
, Ca2+/calmodulin-dependent protein kinase II
, caM kinase II subunit gamma
, caM-kinase II gamma chain
, calcium/calmodulin-dependent protein kinase type II gamma chain