anti-VHL (VHL) Antikörper

Bezeichnung:
anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase Antikörper (VHL)
Auf www.antikoerper-online.de finden Sie aktuell 132 Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen VHL Kits (15) und VHL Proteine (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 163 VHL Produkte verfügbar.
Synonyme:
BcDNA:RH61560, CG13221, d-vhl, Dmel\\CG13221, dmVHL, dVHL, hrca1, pVHL, rca1, vhl, vhl1, Vhlh, zgc:158722

Meistgesuchte Reaktivitäten zu anti-VHL (VHL) Antikörper

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anti-Human VHL Antikörper:

anti-Mouse (Murine) VHL Antikörper:

anti-Rat (Rattus) VHL Antikörper:

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Am meisten referenzierte anti-VHL Antikörper

  1. Human Monoclonal VHL Primary Antibody für IHC (f), IP - ABIN967508 : Baba, Hirai, Kawakami, Kishida, Sakai, Kaneko, Yao, Shuin, Kubota, Hosaka, Ohno: Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth. in Oncogene 2001 (PubMed)
    Zeige alle 7 Referenzen für 967508

  2. Human Monoclonal VHL Primary Antibody für ELISA, WB - ABIN393528 : Peña, Lathia, Shan, Escudier, Bukowski: Biomarkers predicting outcome in patients with advanced renal cell carcinoma: Results from sorafenib phase III Treatment Approaches in Renal Cancer Global Evaluation Trial. in Clinical cancer research : an official journal of the American Association for Cancer Research 2010 (PubMed)
    Zeige alle 5 Referenzen für 393528

  3. Human Monoclonal VHL Primary Antibody für IHC (fro), IHC (p) - ABIN264443 : Los, Jansen, Kaelin, Lips, Blijham, Voest: Expression pattern of the von Hippel-Lindau protein in human tissues. in Laboratory investigation; a journal of technical methods and pathology 1996 (PubMed)
    Zeige alle 4 Referenzen für 264443

  4. Human Polyclonal VHL Primary Antibody für EIA, WB - ABIN453457 : Olmos, Arenas, Bienes, Calzada, Aragonés, Garcia-Bermejo, Landazuri, Lucio-Cazaña: 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. in Cellular and molecular life sciences : CMLS 2009 (PubMed)
    Zeige alle 3 Referenzen für 453457

  5. Human Polyclonal VHL Primary Antibody für IHC, ELISA - ABIN1533202 : Latif, Tory, Gnarra, Yao, Duh, Orcutt, Stackhouse, Kuzmin, Modi, Geil: Identification of the von Hippel-Lindau disease tumor suppressor gene. in Science (New York, N.Y.) 1993 (PubMed)

  6. Human Monoclonal VHL Primary Antibody für EIA, IHC (p) - ABIN121157 : Staller, Sulitkova, Lisztwan, Moch, Oakeley, Krek: Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. in Nature 2003 (PubMed)

  7. Human Polyclonal VHL Primary Antibody für ELISA, WB - ABIN185675 : Kong, Lin, Liang, Fath, Sang, Caro: Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. in Molecular and cellular biology 2006 (PubMed)

Weitere Antikörper gegen VHL Interaktionspartner

Human Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) Interaktionspartner

  1. It has been proposed that the archetypal linker protein Rootletin maintains centrosome cohesion in part through inhibition of VHL-mediated Cep68 degradation.

  2. Results show that VHL missense mutations may exert mild, moderate or strong impact on protein stability. Besides the HIF binding domain, other pVHL binding sites seem to be non-randomly altered by missense mutations in sporadic clear cell renal cell carcinoma (zeige MOK Antikörper).

  3. Data identify VHL as an E3 ligase with important cellular functions under both normoxic and hypoxic conditions.

  4. Moderate/strong NEMO (zeige IKBKG Antikörper) protein expression is more frequent in VHL wild-type ccRCCs.

  5. The Absence of MCM7 (zeige MCM7 Antikörper) weakened the interaction between Cep68 and VHL, whereas MCM7 (zeige MCM7 Antikörper) overexpression facilitated the Cep68-VHL association.

  6. this meta-analysis indicates that VHL gene alteration has no prognostic or predictive value in patients with clear cell renal cell carcinoma (zeige MOK Antikörper)

  7. Low VHL expression is associated with Clear cell renal cell carcinoma (zeige MOK Antikörper).

  8. The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2alpha (zeige EPAS1 Antikörper) signaling may then lead to differentially modulated RCC (zeige XRCC1 Antikörper) progression in a VHL-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2alpha (zeige EPAS1 Antikörper)/C-MYC (zeige MYC Antikörper) signals against RCC (zeige XRCC1 Antikörper) progression.

  9. Our study reveals a novel mechanism regulating VHL proteostasis and function, which is significant for identifying new drug targets and developing new therapeutic approaches targeting VHL deficiency in VHL diseases.

  10. The prefoldin subunit Pac10 (the human homolog VBP-1 (zeige PFDN3 Antikörper) binds to pVHL) is required for pVHL stability. Reduction of soluble functional pVHL might be crucial in VHL-related diseases.

Fruit Fly (Drosophila melanogaster) Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) Interaktionspartner

  1. Interaction between Nm23 (zeige NME1 Antikörper) and the tumor suppressor VHL

  2. Transgenic pVHL can fully maintain normal dVHL-HIF1-alpha (zeige HIF1A Antikörper) downstream pathways in flies.

  3. Codepletion of Vhl with Mgr (zeige GRHL1 Antikörper) gives partial rescue of tubulin (zeige TUBB Antikörper) instability, monopolar spindle formation, and loss of centrosomes.

  4. The results establish a developmental function of the VHL gene that is relevant to its tumor-suppressor activity.

  5. findings reveal a second type of tracheal hypoxic response in which Sima activation conflicts with developmental tracheogenesis, and identify the dVHL and ago ubiquitin ligases as key determinants of hypoxia sensitivity in tracheal cells

Zebrafish Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) Interaktionspartner

  1. In this review, we have tried to bring together knowledge on the HIF/hypoxic signaling pathway in zebrafish, including what is known on VHL functions.

  2. by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (zeige FOXO3 Antikörper) (foxo3b) plays an important role in survival in response to hypoxic stress.

  3. Zebrafish embryos lacking endogenous vhl lead to defective phenotypes in the renal system that were characterized by the curved and cystic pronephric tubule or/and a cystic and malformed glomerulus.

  4. Inhibiting PHD (zeige PDC Antikörper) or knocking down VHL rescues Methyl tert (zeige TERT Antikörper)-butyl ether induced vascular lesions.

  5. Zebrafish vhl mutants display a marked increase in blood vessel formation throughout the embryo, and the most severe neovascularization is observed in distinct areas that overlap with high vegfa (zeige VEGFA Antikörper) mRNA expression, including the vhl mutant brain and eye.

  6. Vhl mutants develop polycythemia with increased epo (zeige EPO Antikörper)/epor (zeige EPOR Antikörper) mRNA & erythropoietin (zeige EPO Antikörper) signaling. VHL regulates hematopoiesis & erythroid differentiation. Zebrafish vhl mutants are the 1st congenital embryonic viable systemic vertebrate animal model for VHL.

Mouse (Murine) Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) Interaktionspartner

  1. High VHL expression is associated with liver fibrosis.

  2. Study demonstrated that mice with a loss of one allele of the VHL gene exhibited normal phenotypes without evidence of predisposition to the development of CNS-hemangioblastomas. Heterozygous VHL +/- mice exhibited the neuroprotective response to acute cerebral ischemia/reperfusion injury due to enhanced angiogenesis by HIF-dependent regulation and HIF-independent Twist 1 (zeige TWIST1 Antikörper) signaling.

  3. These results support the idea that the development of a full-blown VHL disease phenotype requires inactivation of the VHL gene not only in the tumor proper, but also in the stromal compartment.

  4. Combined deletion of Vhl, Trp53 (zeige TP53 Antikörper) and Rb1 (zeige RB1 Antikörper) specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma (zeige MOK Antikörper).

  5. pVHL has a pivotal role in bleomycin-induced pulmonary fibrosis.

  6. These findings reveal VHL-HIF-mediated metabolic compartmentalization in the developing heart and the connection between metabolism and myocardial differentiation.

  7. Longitudinal microcomputed tomography (muCT) imaging and histopathological analyses revealed an increased rate of cyst formation, increased proportion of cysts with proliferating cells, higher frequency of atypical cysts as well as the development of neoplasms in Vhl/Kif3a (zeige KIF3A Antikörper)/Trp53 (zeige TP53 Antikörper) mutant kidneys compared to Kif3a (zeige KIF3A Antikörper)/Trp53 (zeige TP53 Antikörper) or Vhl/Kif3a (zeige KIF3A Antikörper) mutant kidneys.

  8. Loss of Vhl in mesenchymal progenitors of the limb bud caused severe fibrosis of the synovial joints and formation of aggressive masses with histologic features of mesenchymal tumors.

  9. These data suggested that intestinal epithelial cells were injured after IM treatment through the pVHL overexpression-induced degradation of collagen I or HIF-1alpha (zeige HIF1A Antikörper).

  10. Vhl and Kif3a (zeige KIF3A Antikörper) deletion accelerates renal cyst formation

VHL Antigen-Profil

Beschreibung des Gens

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with VHL

  • von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL) Antikörper
  • von Hippel-Lindau (Vhl) Antikörper
  • von Hippel-Lindau tumor suppressor (VHL) Antikörper
  • von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (vhl) Antikörper
  • von Hippel-Lindau tumor suppressor (vhl) Antikörper
  • von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992) Antikörper
  • von Hippel-Lindau tumor suppressor (Vhl) Antikörper
  • von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (Vhl) Antikörper
  • BcDNA:RH61560 Antikörper
  • CG13221 Antikörper
  • d-vhl Antikörper
  • Dmel\\CG13221 Antikörper
  • dmVHL Antikörper
  • dVHL Antikörper
  • hrca1 Antikörper
  • pVHL Antikörper
  • rca1 Antikörper
  • vhl Antikörper
  • vhl1 Antikörper
  • Vhlh Antikörper
  • zgc:158722 Antikörper

Bezeichner auf Proteinebene für VHL

elongin binding protein , protein G7 , von Hippel-Lindau disease tumor suppressor , CG13221-PA , CG13221-PB , Vhl-PA , Vhl-PB , von hippel lindau , von hippel lindau protein , pVHL , von Hippel-Lindau tumor suppressor , von Hippel-Lindau syndrome homolog , von Hippel-Lindau syndrome protein homolog , Von Hippel-Lindau disease tumor suppressor

GENE ID SPEZIES
7428 Homo sapiens
53433 Drosophila melanogaster
100173372 Pongo abelii
494000 Canis lupus familiaris
416117 Gallus gallus
549121 Xenopus (Silurana) tropicalis
791202 Danio rerio
540957 Bos taurus
6042662 Culex quinquefasciatus
22346 Mus musculus
24874 Rattus norvegicus
100380306 Salmo salar
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