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A novel frameshift mutation in PODXL seems to be the likely cause of ARJP in this family.
These findings suggest a potential functional link in colorectal cancer between PODXL, EGFR (zeige EGFR Proteine) and BRAF (zeige BRAF Proteine).
PODXL enhances motility and invasiveness through an increase in gelsolin-actin interactions in cell protrusions.
Results identify an anti-metastatic miRNA, miR (zeige MLXIP Proteine)-5100, that decreases the metastatic ability of pancreatic cancer partially by suppressing expression of PODXL.
Results indicate that urinary podocalyxin is not only an early marker but also a treatment target for diabetic nephropathy (DN).
Obese subjects showed evidence of renal alteration through the detection of a higher number of urinary podocalyxin positive cells.
Data show that both mucin16 (MUC16 (zeige MUC16 Proteine)) and podocalyxin (PODXL)-E-selectin (zeige SELE Proteine)-mediated interactions are mechanically stronger than like L-selectin (zeige SELL Proteine) interactions at the single-molecule level.
In gastric cancer, PODXL expression by the polyclonal antibody HPA2110 is an independent marker of poor prognosis.
PCX (zeige PC Proteine) promotes cisplatin chemoresistance in osteosarcoma cells through a PI3Kdependent mechanism.
EZR (zeige EZR Proteine), CLIC5 (zeige CLIC5 Proteine) and PODXL are overexpressed in hepatocellular carcinoma and may have a role in cell migration and invasiveness
Podocalyxin-like protein 1 is a relevant marker for human c-kit(pos) cardiac stem cells.(
Podxl-KO led to heightened G-CSF (zeige CSF3 Proteine) activation of Rap1a (zeige RAP1A Proteine)(GTP (zeige AK3 Proteine)), and Rap1a (zeige RAP1A Proteine)(GTP (zeige AK3 Proteine)) inhibition attenuated Podxl-KO neutrophil migration. Studies have revealed novel roles for Podxl as an important modulator of neutrophil and monocyte formation and of Rap1a (zeige RAP1A Proteine) activation during stress hematopoiesis.
Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2 (zeige ANXA2 Proteine).
when endogenous podocalyxin was removed from highly metastatic 4T1 mammary tumor cells there was a decrease in collective invasion . Podocalyxin is a tumor cell-intrinsic regulator of experimental collective tumor cell invasion and tumor budding.
Podocalyxin has a role in glioblastoma multiforme cell invasion and proliferation via beta-catenin (zeige CTNNB1 Proteine) signaling
Loss of podocalyxin from the lung vasculature results in changes to the lung structure and function including increased lung volume when inflated under constant pressure (25 cm H2O) and changes to the matrix composition.
CTGF is an important mediator of high glucose-induced podocyte damage and decreases the protein level of podocalyxin by the ERK1/2 pathway.
platelet Podxl is involved in the control of hemostasis acting as a platelet co-stimulator, likely due to its pro-adhesive properties
Full-length recombinant murine podocalyxin recruits NHERF-1 (zeige SLC9A3R1 Proteine) to the apical domain. Ectopic expression in human & canine epithelial cells leads to microvilli formation on an apical domain extending laterally to the junctional complexes.
Podocalyxin plays multiple roles in neural development
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
, podocalyxin-like protein 1-like
, GCTM-2 antigen
, podocalyxin-like protein 1
, PC-like protein 1
, Podocalyxin-like protein 1