DVL2 Proteine (DVL2)

Bezeichnung:
Dishevelled, Dsh Homolog 2 (Drosophila) Proteine (DVL2)
Auf www.antikoerper-online.de finden Sie aktuell 3 Dishevelled, Dsh Homolog 2 (Drosophila) (DVL2) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DVL2 Antikörper (109) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 118 DVL2 Produkte verfügbar.
Synonyme:
dishevelled, dsh, dvl, Dvl-2, wu:fc05d12, wu:fo71e09, wu:fp54a02, xdsh, zgc:55372
alle Proteine anzeigen Gen GeneID UniProt
Ratte DVL2 DVL2 303251  
DVL2 13543 Q60838
DVL2 1856 O14641

Weitere Synonyme anzeigen

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Weitere Proteine zu DVL2 Interaktionspartnern

Mouse (Murine) Dishevelled, Dsh Homolog 2 (Drosophila) (DVL2) Interaktionspartner

  1. Epsins are required for Dishevelled stability and Wnt (zeige WNT2 Proteine) signalling activation in colon cancer development.

  2. Dpr1 (zeige DACT1 Proteine) promotes the ubiquitination of Dvl2 by pVHL (zeige VHL Proteine) and mediates the protein aggregate-elicited autophagy initiation

  3. Dvl2 binds to Rab35 (zeige RAB35 Proteine) and activation is required for MCF-7 cell migration

  4. Dvl-2 and Dvl-3 (zeige DVL3 Proteine) have a widespread distribution in both the olfactory epithelium and olfactory bulb

  5. Dullard (zeige DULLARD Proteine) may play a role in the fine-tuning of WNT (zeige WNT2 Proteine) signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage.

  6. loss of Dvl2 function in Vangl2(Lp (zeige VANGL2 Proteine)/+) embryos did not exacerbate the Vangl2(Lp (zeige VANGL2 Proteine)/+) neuronal migration phenotype

  7. Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.

  8. These findings suggest that Wnt5a (zeige WNT5A Proteine)-Ror-Dishevelled signaling constitutes a core noncanonical Wnt (zeige WNT2 Proteine) pathway that is conserved through evolution and is crucial during embryonic development.

  9. Dvl2 has an inhibitory role in myogenesis and Stau1 (zeige STAU1 Proteine) coordinates myogenesis through the regulation of Dvl2 mRNA.

  10. GABARAPL1 (zeige GABARAPL1 Proteine) negatively regulates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling by mediating Dvl2 degradation through the autophagy pathway.

Human Dishevelled, Dsh Homolog 2 (Drosophila) (DVL2) Interaktionspartner

  1. two mutually exclusive functions of the DEP domain in Wnt (zeige WNT2 Proteine) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.

  2. inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.

  3. Data show that RAP1B (zeige RAP1B Proteine) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (zeige RAP1B Proteine) interacted with DVL2 and activated Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.

  4. ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.

  5. Data show that dishevelled proteins DVL1 (zeige DVL1 Proteine), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).

  6. The secreted frizzled-related protein (zeige SFRP2 Proteine) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.

  7. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1 (zeige FOXE1 Proteine)-induced trans-activation of Snail (zeige SNAI1 Proteine), which promotes proliferation and metastasis.

  8. Epsins are required for Dishevelled stability and Wnt (zeige WNT2 Proteine) signalling activation in colon cancer development.

  9. The data suggest that the expression of DVL2 in colon tissue segments may be important in the pathogenesis of HSCR (zeige EDNRB Proteine).

  10. Elevated DVL2 expression is associated with drug resistance in colorectal cancer.

Xenopus laevis Dishevelled, Dsh Homolog 2 (Drosophila) (DVL2) Interaktionspartner

  1. CapZIP (zeige RCSD1 Proteine), which has been shown to regulate ciliogenesis, is an ERK7 (zeige MAPK15 Proteine) substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 (zeige MAPK15 Proteine) phosphorylation of CapZIP (zeige RCSD1 Proteine) through binding to both ERK7 (zeige MAPK15 Proteine) and CapZIP (zeige RCSD1 Proteine).

  2. Different Dvl proteins (Dvl1 (zeige DVL1 Proteine), Dvl2, Dvl3 (zeige DVL3 Proteine)) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (zeige WNT2 Proteine) signaling in Xenopus gastrulation.

  3. these findings suggest that regulation of Dvl protein levels by NEDD4L (zeige NEDD4L Proteine) is essential for convergent extension during early Xenopus embryogenesis.

  4. findings reveal that, in response to Wnt (zeige WNT2 Proteine) signalling, Dishevelled inhibits CSL (zeige SMPX Proteine) transcription factors to regulate Notch (zeige NOTCH1 Proteine) signalling and cell-fate decisions in vivo

  5. Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin.

  6. The archenteron elongation is independent of Xdsh signaling, especially during the second half of gastrulation.

  7. Subcellular localization is insufficient to account for the pathway specificity of Dishevelled in the canonical Wnt (zeige WNT2 Proteine) versus PCP (zeige PRCP Proteine) signaling cascades.

  8. both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells

  9. Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 (zeige EFNB1 Proteine) and mediates ephrinB1 (zeige EFNB1 Proteine) signalling through downstream members of the PCP (zeige PRCP Proteine) pathway during eye field formation.

  10. The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling.

Zebrafish Dishevelled, Dsh Homolog 2 (Drosophila) (DVL2) Interaktionspartner

  1. demonstrate that during early zebrafish development Nkd1 (zeige NKD1 Proteine) does not alter either endogenous or exogenous levels of Dvl2

DVL2 Protein Überblick

Protein Überblick

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

Alternative names and synonyms associated with DVL2

  • dishevelled, dsh homolog 2 (Drosophila) (DVL2)
  • dishevelled segment polarity protein 2 (dvl2)
  • dishevelled 2 (Dvl2)
  • dishevelled 2, dsh homolog (Drosophila) (Dvl2)
  • dishevelled segment polarity protein 2 (DVL2)
  • dishevelled, dsh homolog 2 (Drosophila) (dvl2)
  • dishevelled Protein
  • dsh Protein
  • dvl Protein
  • Dvl-2 Protein
  • wu:fc05d12 Protein
  • wu:fo71e09 Protein
  • wu:fp54a02 Protein
  • xdsh Protein
  • zgc:55372 Protein

Bezeichner auf Proteinebene für DVL2

DSH homolog 2 , Dishevelled-2 , dishevelled, dsh homolog 2 , segment polarity protein dishevelled homolog DVL-2 , dishevelled 2 , dishevelled, dsh homolog 2 (Drosophila) , dishevelled-2 , dishevelled 2 (homologous to Drosophila dsh) , dishevelled homolog , dishevelled 2, dsh homolog

GENE ID SPEZIES
100625452 Sus scrofa
780117 Xenopus (Silurana) tropicalis
455236 Pan troglodytes
100061612 Equus caballus
303251 Rattus norvegicus
13543 Mus musculus
1856 Homo sapiens
399301 Xenopus laevis
323630 Danio rerio
489464 Canis lupus familiaris
614312 Bos taurus
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