Sorcin Proteine (SRI)

Sorcin Proteine (SRI)
Auf finden Sie aktuell 15 Sorcin (SRI) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Sorcin Antikörper (43) und Sorcin Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 68 Sorcin Produkte verfügbar.
2210417O06Rik, 2900070H08Rik, CP-22, CP22, SCN, Sor, SRI, V19, zgc:64070
alle Proteine anzeigen Gen GeneID UniProt
SRI 6717 P30626
SRI 109552 Q6P069
Ratte SRI SRI 683667  

Weitere Synonyme anzeigen

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Am meisten referenzierte Sorcin Proteine

  1. Human SRI Protein expressed in Escherichia coli (E. coli) - ABIN667371 : Landriscina, Laudiero, Maddalena, Amoroso, Piscazzi, Cozzolino, Monti, Garbi, Fersini, Pucci, Esposito: Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents. in Cancer research 2010 (PubMed)
    Zeige alle 2 Referenzen für 667371

  2. Human SRI Protein expressed in Baculovirus infected Insect Cells - ABIN2006222 : Brownawell, Creutz: Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). in The Journal of biological chemistry 1997 (PubMed)

Weitere Proteine zu Sorcin Interaktionspartnern

Pig (Porcine) Sorcin (SRI) Interaktionspartner

  1. Foot-and-mouth disease virus VP1 as an interferon (zeige IFNA Proteine)-suppressor by interacting with sorcin.

Human Sorcin (SRI) Interaktionspartner

  1. Sorcin overexpression in HCT116 cells resulted in a significant increase in cell migration and invasion. Sorcin stimulated epithelial-mesenchymal transition through activating PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling.

  2. The authors verified that NS5A of hepatitis C virus interacted with sorcin through domain I of NS5A, and phosphorylation of the threonine residue 155 of sorcin played a crucial role in protein interaction.

  3. Drug resistance can be effectively reversed in cisplatin-resistance and adriamycin-resistant myeloma cells through delivery of siRNAs targeting sorcin.

  4. Sorcin is highly expressed in the heart and in the brain, and overexpressed in many cancer cells. [Review]

  5. Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study

  6. Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.

  7. Key cellular signaling pathways were triggered by sorcin silencing in the drug resistance of human nasopharyngeal carcinoma.

  8. sorcin regulates epithelial-mesenchymal transition and cancer stem cells partly through E-cadherin and vascular endothelial growth factor expression.

  9. overexpression of sorcin increased the phosphorylation of CREB1 (zeige CREB1 Proteine) and the binding of CREB1 (zeige CREB1 Proteine) to the CRE sequence of mdr1/p-gp (zeige ABCB4 Proteine) promoter, and induced the expression of MDR1/P-gp (zeige ABCB4 Proteine)

  10. down-regulation of sorcin did not alter expression or function of P-gp (zeige ABCB4 Proteine), but induced cell apoptosis and chemosensitivity in K562/ A02 and MCF-7/A02

Mouse (Murine) Sorcin (SRI) Interaktionspartner

  1. Sorcin links pancreatic beta cells lipotoxicity to calcium stores and provides a target for intervention in type 2 diabetes.

  2. Regulation of calcium signaling and cardiac contractility by miR-1 regulated sorcin expression plays a fundamental role in the maintenance of normal cardiac function and in the pathogenesis of cardiac dysfunction.

  3. sorcin is a potent inhibitor of both spontaneous and ICa-triggered RyR (zeige RYR1 Proteine) activity and is kinetically capable of playing a role in terminating the positive feedback loop of Ca2 (zeige CA2 Proteine)+-induced Ca2 (zeige CA2 Proteine)+ release

  4. Data further define the role of sorcin in cardiac excitation-contraction coupling and highlight its negative regulation of sarcoplasmic reticulum calcium release.

  5. Interaction of calcium/calmodulin-dependent protein kinase IIdeltaC with sorcin indirectly modulates ryanodine receptor (zeige RYR3 Proteine) function in cardiac myocytes.

Sorcin (SRI) Protein Überblick

Protein Überblick

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.

Alternative names and synonyms associated with Sorcin (SRI)

  • sorcin (SRI)
  • sorcin (sri)
  • Sorcin (EDI_060410)
  • Sorcin (EDI_160670)
  • Sorcin (EDI_002860)
  • Sorcin (EDI_076560)
  • sorcin (CpipJ_CPIJ004933)
  • sorcin (CpipJ_CPIJ008581)
  • sorcin (Tsp_05707)
  • Sorcin (sorcn)
  • sorcin (Sri)
  • 2210417O06Rik Protein
  • 2900070H08Rik Protein
  • CP-22 Protein
  • CP22 Protein
  • SCN Protein
  • Sor Protein
  • SRI Protein
  • V19 Protein
  • zgc:64070 Protein

Bezeichner auf Proteinebene für Sorcin Proteine (SRI)

sorcin , Sorcin , 22 kDa protein , H_RG167B05.1 , calcium binding protein amplified in mutlidrug-resistant cells

100514123 Sus scrofa
393344 Danio rerio
549421 Xenopus (Silurana) tropicalis
705215 Macaca mulatta
5879089 Entamoeba dispar SAW760
5883304 Entamoeba dispar SAW760
5883371 Entamoeba dispar SAW760
5886423 Entamoeba dispar SAW760
6036401 Culex quinquefasciatus
6040842 Culex quinquefasciatus
10913537 Trichinella spiralis
100037199 Xenopus laevis
100286583 Salmo salar
100302556 Ovis aries
100305213 Oncorhynchus mykiss
734407 Xenopus laevis
420538 Gallus gallus
463518 Pan troglodytes
6717 Homo sapiens
475220 Canis lupus familiaris
508319 Bos taurus
109552 Mus musculus
683667 Rattus norvegicus
100174725 Pongo abelii
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