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Human SRI Protein expressed in Escherichia coli (E. coli) - ABIN667371
Landriscina, Laudiero, Maddalena, Amoroso, Piscazzi, Cozzolino, Monti, Garbi, Fersini, Pucci, Esposito: Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents. in Cancer research 2010
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Human SRI Protein expressed in Baculovirus infected Insect Cells - ABIN2006222
Brownawell, Creutz: Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). in The Journal of biological chemistry 1997
Foot-and-mouth disease virus VP1 as an interferon (zeige IFNA Proteine)-suppressor by interacting with sorcin.
Sorcin overexpression in HCT116 cells resulted in a significant increase in cell migration and invasion. Sorcin stimulated epithelial-mesenchymal transition through activating PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling.
The authors verified that NS5A of hepatitis C virus interacted with sorcin through domain I of NS5A, and phosphorylation of the threonine residue 155 of sorcin played a crucial role in protein interaction.
Drug resistance can be effectively reversed in cisplatin-resistance and adriamycin-resistant myeloma cells through delivery of siRNAs targeting sorcin.
Sorcin is highly expressed in the heart and in the brain, and overexpressed in many cancer cells. [Review]
Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study
Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.
Key cellular signaling pathways were triggered by sorcin silencing in the drug resistance of human nasopharyngeal carcinoma.
sorcin regulates epithelial-mesenchymal transition and cancer stem cells partly through E-cadherin and vascular endothelial growth factor expression.
overexpression of sorcin increased the phosphorylation of CREB1 (zeige CREB1 Proteine) and the binding of CREB1 (zeige CREB1 Proteine) to the CRE sequence of mdr1/p-gp (zeige ABCB4 Proteine) promoter, and induced the expression of MDR1/P-gp (zeige ABCB4 Proteine)
down-regulation of sorcin did not alter expression or function of P-gp (zeige ABCB4 Proteine), but induced cell apoptosis and chemosensitivity in K562/ A02 and MCF-7/A02
Sorcin links pancreatic beta cells lipotoxicity to calcium stores and provides a target for intervention in type 2 diabetes.
Regulation of calcium signaling and cardiac contractility by miR-1 regulated sorcin expression plays a fundamental role in the maintenance of normal cardiac function and in the pathogenesis of cardiac dysfunction.
sorcin is a potent inhibitor of both spontaneous and ICa-triggered RyR (zeige RYR1 Proteine) activity and is kinetically capable of playing a role in terminating the positive feedback loop of Ca2 (zeige CA2 Proteine)+-induced Ca2 (zeige CA2 Proteine)+ release
Data further define the role of sorcin in cardiac excitation-contraction coupling and highlight its negative regulation of sarcoplasmic reticulum calcium release.
Interaction of calcium/calmodulin-dependent protein kinase IIdeltaC with sorcin indirectly modulates ryanodine receptor (zeige RYR3 Proteine) function in cardiac myocytes.
This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.
, 22 kDa protein
, calcium binding protein amplified in mutlidrug-resistant cells