anti-MCOLN1 (MCOLN1) Antikörper

anti-Mucolipin 1 Antikörper (MCOLN1)
Auf finden Sie aktuell 48 Mucolipin 1 (MCOLN1) Antikörper von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MCOLN1 Proteine (3) und MCOLN1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 60 MCOLN1 Produkte verfügbar.
2210015I05Rik, MCOLN1, mcoln1.1, MG-2, ML4, MLIV, mln1, MST080, mucolipidin, mucolipin-1, TRP-ML1, TRPM-L1, TRPML1, zgc:63619
Alle Antikörper anzeigen Gen GeneID UniProt
MCOLN1 57192 Q9GZU1
MCOLN1 94178 Q99J21
MCOLN1 288371  

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-MCOLN1 (MCOLN1) Antikörper

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anti-Human MCOLN1 Antikörper:

anti-Mouse (Murine) MCOLN1 Antikörper:

anti-Rat (Rattus) MCOLN1 Antikörper:

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Am meisten referenzierte anti-MCOLN1 Antikörper

  1. Mouse (Murine) Polyclonal MCOLN1 Primary Antibody für IHC, WB - ABIN350483 : Bargal, Avidan, Ben-Asher, Olender, Zeigler, Frumkin, Raas-Rothschild, Glusman, Lancet, Bach: Identification of the gene causing mucolipidosis type IV. in Nature genetics 2000 (PubMed)
    Zeige alle 10 Referenzen für 350483

  2. Human Polyclonal MCOLN1 Primary Antibody für IHC, WB - ABIN350482 : Bassi, Manzoni, Monti, Pizzo, Ballabio, Borsani: Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV. in American journal of human genetics 2000 (PubMed)
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  3. Human Polyclonal MCOLN1 Primary Antibody für IHC, WB - ABIN350479 : Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: The transcriptional landscape of the mammalian genome. ... in Science (New York, N.Y.) 2005 (PubMed)
    Zeige alle 10 Referenzen für 350479

  4. Human Polyclonal MCOLN1 Primary Antibody für IHC, WB - ABIN350480 : Falardeau, Kennedy, Acierno, Sun, Stahl, Goldin, Slaugenhaupt: Cloning and characterization of the mouse Mcoln1 gene reveals an alternatively spliced transcript not seen in humans. in BMC genomics 2003 (PubMed)
    Zeige alle 10 Referenzen für 350480

  5. Human Polyclonal MCOLN1 Primary Antibody für IHC (p), WB - ABIN657474 : Eichelsdoerfer, Evans, Slaugenhaupt, Cuajungco: Zinc dyshomeostasis is linked with the loss of mucolipidosis IV-associated TRPML1 ion channel. in The Journal of biological chemistry 2010 (PubMed)
    Zeige alle 3 Referenzen für 657474

  6. Cow (Bovine) Polyclonal MCOLN1 Primary Antibody für WB - ABIN2776233 : LaPlante, Ye, Quinn, Goldin, Brown, Slaugenhaupt, Vassilev: Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV. in Biochemical and biophysical research communications 2004 (PubMed)

Weitere Antikörper gegen MCOLN1 Interaktionspartner

Zebrafish Mucolipin 1 (MCOLN1) Interaktionspartner

  1. study characterized mcoln1.1 and mcoln1.2, the putative co-orthologs of human MCOLN1 gene

Human Mucolipin 1 (MCOLN1) Interaktionspartner

  1. TRPML1 supports both Ca(2 (zeige CA2 Antikörper)+) release and Ca(2 (zeige CA2 Antikörper)+) entry.

  2. These data suggest that lysosomal adenosine accumulation impairs lysosome function by inhibiting TRPML1 and subsequently leads to cell death in B-lymphocytes.

  3. Here we identify the lipid kinase PIKfyve (zeige PIKFYVE Antikörper) as a regulator of an alternative pathway that distributes engulfed contents in support of intracellular macromolecular synthesis during macropinocytosis, entosis, and phagocytosis. We find that PIKfyve (zeige PIKFYVE Antikörper) regulates vacuole size in part through its downstream effector, the cationic transporter TRPML1

  4. findings suggest that TRPML1 may function as a key lysosomal Ca(2 (zeige CA2 Antikörper)+) channel controlling both lysosome biogenesis and reformat

  5. This review summarizes the current understanding of TRPML1 activation and regulation

  6. target of rapamycin (TOR), a nutrient-sensitive protein kinase that negatively regulates autophagy, directly targets and inactivates the TRPML1 channel and thereby functional autophagy, through phosphorylation

  7. lysosomal adaptation to environmental cues such as nutrient levels requires mTOR (zeige FRAP1 Antikörper)/TFEB (zeige TFEB Antikörper)-dependent, lysosome-to-nucleus regulation of lysosomal ML1 channels and Ca(2 (zeige CA2 Antikörper)+) signaling.

  8. TRPML1 has a novel role in protecting against lysosomotropic amine toxicity.

  9. Retinal pigmented epithelial cells develop a punctate phenotype within 48 hours of small interfering (si)RNA-induced TRPML1-knockdown.

  10. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.

Cow (Bovine) Mucolipin 1 (MCOLN1) Interaktionspartner

  1. an NAADP-sensitive Ca(2 (zeige CA2 Antikörper)+) release channel is characteristic of TRP-ML1 channels

Mouse (Murine) Mucolipin 1 (MCOLN1) Interaktionspartner

  1. Deletion of TRPML1 increases secretory organelle size by fusion with lysosomes. Enhanced exocytosis that was rescued by re-expression of TRPML1 in neurons.

  2. Silencing of TRPML1 hindered phagosome fusion with lysosomes.

  3. These results demonstrate that the PtdIns(3,5)P2-Mcoln1 axis has an important role in ssRNA transportation into lysosomes in DCs.

  4. ML1-null mice develop a primary, early-onset muscular dystrophy independent of neural degeneration. Dystrophin-glycoprotein complex and known membrane repair proteins are expressed normally, but membrane resealing was defective in ML1-null muscle fibers.

  5. Data identified proteins as candidate TRPML1 interactors, and some false-positive interactors.

  6. Transfection of CAMs with plasmids containing a full-length TRP-ML1 gene enhanced FasL (zeige FASL Antikörper)-induced two-phase Ca2 (zeige CA2 Antikörper)+ release.

  7. Loss of Trpml1 causes reduced levels and mislocalization of the gastric proton pump and alters the secretory canaliculi, causing hypochlorhydria and hypergastrinemia.

  8. This study describes, for the first time, a defect in macroautophagy in mucolipin-1-deficient mouse neurons.

  9. the loss of TRPML1 function results in intracellular chelatable zinc dyshomeostasis.

  10. TRPML1 is expressed in the mouse inner ear.

MCOLN1 Antigen-Profil

Beschreibung des Gens

This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.

Alternative names and synonyms associated with MCOLN1

  • mucolipin 1a (mcoln1a) Antikörper
  • mucolipin 1 (MCOLN1) Antikörper
  • mucolipin 1 (mcoln1) Antikörper
  • mucolipin 1 (LOAG_04987) Antikörper
  • mucolipin 1 (Mcoln1) Antikörper
  • 2210015I05Rik Antikörper
  • MCOLN1 Antikörper
  • mcoln1.1 Antikörper
  • MG-2 Antikörper
  • ML4 Antikörper
  • MLIV Antikörper
  • mln1 Antikörper
  • MST080 Antikörper
  • mucolipidin Antikörper
  • mucolipin-1 Antikörper
  • TRP-ML1 Antikörper
  • TRPM-L1 Antikörper
  • TRPML1 Antikörper
  • zgc:63619 Antikörper

Bezeichner auf Proteinebene für anti-Mucolipin 1 (MCOLN1) Antikörper

mucolipin 1 , mucolipin 1.1 , mucolipidin , mucolipidosis type IV protein , mucolipin-1

406689 Danio rerio
426164 Gallus gallus
444113 Xenopus laevis
455656 Pan troglodytes
496811 Xenopus (Silurana) tropicalis
9942391 Loa loa
100601142 Nomascus leucogenys
57192 Homo sapiens
611517 Canis lupus familiaris
505738 Bos taurus
94178 Mus musculus
288371 Rattus norvegicus
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