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the DNA fragment containing the associated SNPs interacts through chromatin looping not only with TNFAIP3, but also with IL20RA (zeige IL20RA Proteine), located 680 kb upstream.
The findings suggest that TNFAIP3 protein may be an independent prognostic marker for poor survival, and a promising target for esophageal squamous cell carcinoma therapy.
Study demonstrates that the rs7749323 in the TNFAIP3 gene is strongly associated with the late onset myasthenia gravis(with positive AChR Ab but without thymoma).
Influenza a virus NS1 (zeige PTPN11 Proteine) has a role in inducing A20 contributes to viral replication by suppressing interferon (zeige IFNA Proteine)-induced antiviral response
Inductive regulation of A20 by glucocorticoid receptor (zeige NR3C1 Proteine) and NF-kappaB (zeige NFKB1 Proteine) contributes to cytokine repression in human airway smooth muscle.
Our study confirms the involvement of the TNFAIP3 tumor suppressor gene in classic Hodgkin lymphoma.
A20 may be a potential therapeutic target for DLBCL.
There is a significantly higher occurrence of the A20 rs143002189 polymorphism in diffuse large B cell lymphoma (DLBCL) compared to non-neoplastic controls and other types of B cell malignancies.
HMBA was able to increase prostratin-induced phosphorylation and degradation of NF-kappaB (zeige NFKB1 Proteine) inhibitor IkappaBalpha (zeige NFKBIA Proteine), thereby enhancing and prolonging prostratin-induced nuclear translocation of NF-kappaB (zeige NFKB1 Proteine), a prerequisite for stimulation of transcription initiation
A Japanese family case with juvenile onset Behcet's disease caused by TNFAIP3 mutation.
these data reveal a crucial role of A20 in regulating the immunomodulatory activities of mesenchymal stem cells.
Therefore, A20 acts as a novel endogenous regulator of STAT1 (zeige STAT1 Proteine) that prevents onset of enthesitis.
This study demonstrated that miR (zeige MLXIP Proteine)-136-5p affected the expression of A20 in IL-17 (zeige IL17A Proteine)-stimulated astrocytes.
Our data suggest that NAOs have a beneficial preventive effect in septic shock correlated with the enhancement of IL-10 (zeige IL10 Proteine) via the induction of A20 and COX-2.
Forced expression of A20 resulted in decreased expression of key markers of lipogenesis and adipogenesis, such as sterol regulatory element binding protein (zeige CNBP Proteine) 1c (SREBP-1c (zeige SREBF1 Proteine)) and adipogenesis (aP2 (zeige TFAP2A Proteine)), leading to less lipids accumulation in differentiated 3T3-L1 cells
these results suggest that Mycobacterium fortuitum-induced activation of host proinflammatory responses is negatively regulated through TLR2-dependent A20 expression.
knockdown of A20 in tumor site inhibited tumor growth at least through inducing the apoptosis of MDSCs. A20 might be a potential target in anticancer therapy.
MiR (zeige MLXIP Proteine)-221 directly targets A20, a master regulator of NF-kappaB (zeige NFKB1 Proteine) and MAPK (zeige MAPK1 Proteine) signaling, and thus represses inflammatory signaling. Restoration of A20 in macrophages abolished the stimulatory effect of miR (zeige MLXIP Proteine)-221 on production of proinflammatory cytokines.
A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.
Our results show that miR (zeige MLXIP Proteine)-873 elevates A20 levels and inhibits morphine-induced macrophage apoptosis.
Data show the characterization and deduced amino acid sequence analysis for A20 gene which expression increases in MDBK cells infected by BVDV-1. Also, regulatory regions for NF-kappaB (zeige NFKB1 Proteine) and Sp-1 (zeige SP1 Proteine) additionally to an ARE element for mRNA stability were detected
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
tumor necrosis factor, alpha-induced protein 3
, OTU domain-containing protein 7C
, TNF alpha-induced protein 3
, putative DNA-binding protein A20
, tumor necrosis factor alpha-induced protein 3
, tumor necrosis factor inducible protein A20
, zinc finger protein A20
, tumor necrosis factor induced protein 3