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Human TSH receptor Protein expressed in Wheat germ - ABIN1330596
Nagata, Nakayama, Higaki, Ochi, Kanai, Matsushita, Kuwamoto, Kato, Murakami, Iwasaki, Nanba, Kimura, Hayashi: Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface. in Autoimmunity 2015
Functional thyroid differentiation in zebrafish was examined and the role of TSHR signaling during thyroid organogenesis, was characterized.
Congenital Hypothyroidism With Gland-in-Situ 59% attributable to mutations in TSHR.
data support the association that low intrathymic TSHR expression is associated with susceptibility to developing pathogenic TSHR antibodies, while high intrathymic TSHR expression is protective
Graves' disease is associated with polymorphisms of TSHR intron 1 rs179247 and rs12101255. There is no association between rs179247 SNPs and Graves' ophthalmopathy
TSHR gene mutations p.R528C and c.392+4del4 associated with congenital hypothyroidism.
this study shows that the TSHR is not main factor contributing to determining common genetic basis among Graves disease and alopecia areata
TSHR D727E polymorphism might be involved in the pathogenesis of toxic multinodular goiter
lncRNA PVT1 may contribute to tumorigenesis of thyroid cancer through recruiting EZH2 (zeige EZH2 Proteine) and regulating TSHR expression.
experimentally verified contact of Ser (zeige SIGLEC1 Proteine)-281 (ECD (zeige SHFM1 Proteine)) and Ile-486 (TMD (zeige TTN Proteine)) was subsequently utilized in docking homology models of the ECD (zeige SHFM1 Proteine) and the TMD (zeige TTN Proteine) to create a full-length model of a glycoprotein hormone receptor (zeige NR4A1 Proteine)
TSHR gene polymorphisms are associated with typical symptoms in primary congenital hypothyroidism.
The eminent ratio of TSHr methylation in well-differentiated thyroid carcinoma against benign thyroidal nodules adduced that TSHr methylation status can be utilized as a tumor marker for well-differentiated thyroid cancer.
Data indicate that splenic T cells from thyroid stimulating hormone receptor (TSHR) A-subunit primed animals undergoing Graves' orbitopathy (GO) showed proliferative responses to purified TSHR antigen and secreted proinflammatory cytokines.
Lung fibroblasts of TSHR KO mice have decreased cell surface Igf1r (zeige IGF1R Proteine) expression, and have Igf1r (zeige IGF1R Proteine) protein and protein fragments in both cytoplasm and nucleus. Igf1r (zeige IGF1R Proteine) mRNA levels were similar between TSHR KO and WT mice.
The mechanism, underlying TSH-induced liver triglyceride accumulation, involved that TSH, through its receptor TSHR, triggered hepatic SREBP-1c (zeige SREBF1 Proteine) activity.
These findings suggest that activation of TSHR directly inhibits FASN (zeige FASN Proteine) expression in mature adipocytes, possibly mediated by PKA and ERK (zeige EPHB2 Proteine)
A novel role for TSHR in behavioral and neurological phenotypes of Attention deficit/hyperactivity disorder.
The data indicate functional TSHR is expressed in ventricular myocytes and mediates TSH-induced BNP secretion and HMGCR (zeige HMGCR Proteine) up-regulation through the cAMP/PKA/pCREB signaling pathway.
findings demonstrate TSH-R expression is thymus-specific within the immune system; data support the notion of a novel neuroendocrine-immune interaction in which TSH-R signaling in the thymus, most likely mediated by TSH, enhances thymic T-cell development
The inhibition of hepatic PEPCK (zeige PEPCK Proteine) and G6P and enhanced expression of GK contributed to the development of fasting hypoglycemia in Tshr-ko mice.
UCP-1 (zeige UCP1 Proteine) and TSHR co-localized in retrobulbar adipose tissues in murine models of Graves' disease.
Cloned a thyroid-stimulating hormone receptor (TSHR) cDNA from thyroid glands. The sequence of this cDNA indicated that it encoded a 739 amino acid TSHR splice variant that lacked exon 5 (TSHR739).
Localization of thyrotropin receptor and thyroglobulin (zeige TG Proteine) in the bovine corpus luteum.
analysis of activation switch in the thyrotropin receptor
Rhes (zeige RASD2 Proteine) can interfere with the functional activity of wt and mutated TSHr.
Increased receptor binding by bovine (b) TSH bound to monoclonal antibody to bTSHbeta-subunit.
the hinge region represents an extracellular intermediate connector for both hormone binding and signal transduction of the thyroid stimulating hormone receptor
The equine TSHR is not responsive to equine chorionic gonadotropin but is more sensitive to human CG than the human TSHR
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
, thyroid-stimulating hormone receptor
, thyrotropin receptor
, seven transmembrane helix receptor
, thyrotropin receptor-I, hTSHR-I