TSH receptor Proteine (TSHR)

Thyroid Stimulating Hormone Receptor Proteine (TSHR)
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AI481368, CHNG1, hTSHR-I, hypothroid, hyt, LGR3, pet, TSH-R, TSHRA
alle Proteine anzeigen Gen GeneID UniProt
TSHR 7253 P16473
TSHR 22095 P47750
TSHR 25360 P21463

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Am meisten referenzierte TSH receptor Proteine

  1. Human TSH receptor Protein expressed in Wheat germ - ABIN1330596 : Nagata, Nakayama, Higaki, Ochi, Kanai, Matsushita, Kuwamoto, Kato, Murakami, Iwasaki, Nanba, Kimura, Hayashi: Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface. in Autoimmunity 2015 (PubMed)
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Weitere Proteine zu TSH receptor Interaktionspartnern

Zebrafish Thyroid Stimulating Hormone Receptor (TSHR) Interaktionspartner

  1. Functional thyroid differentiation in zebrafish was examined and the role of TSHR signaling during thyroid organogenesis, was characterized.

Human Thyroid Stimulating Hormone Receptor (TSHR) Interaktionspartner

  1. Data (including data from studies using knockout mice) suggest that thyrotropin/thyrotropin receptor signal transduction stimulates thyroglobulin (zeige TG Proteine) phosphorylation and contributes to enhanced de novo triiodothyronine formation in thyrocytes.

  2. a hot-spot mutation in EZH1 (zeige EZH1 Proteine) is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 (zeige EZH1 Proteine) and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 (zeige EZH1 Proteine) mutations cooperate to induce the hyperproliferation of thyroid cells

  3. Germline mutation in the thyrotropin receptor gene is associated with non-autoimmune hyperthyroidism.

  4. Congenital Hypothyroidism With Gland-in-Situ 59% attributable to mutations in TSHR.

  5. data support the association that low intrathymic TSHR expression is associated with susceptibility to developing pathogenic TSHR antibodies, while high intrathymic TSHR expression is protective

  6. Graves' disease is associated with polymorphisms of TSHR intron 1 rs179247 and rs12101255. There is no association between rs179247 SNPs and Graves' ophthalmopathy

  7. TSHR gene mutations p.R528C and c.392+4del4 associated with congenital hypothyroidism.

  8. this study shows that the TSHR is not main factor contributing to determining common genetic basis among Graves disease and alopecia areata

  9. TSHR D727E polymorphism might be involved in the pathogenesis of toxic multinodular goiter

  10. lncRNA PVT1 may contribute to tumorigenesis of thyroid cancer through recruiting EZH2 (zeige EZH2 Proteine) and regulating TSHR expression.

Mouse (Murine) Thyroid Stimulating Hormone Receptor (TSHR) Interaktionspartner

  1. Data indicate that splenic T cells from thyroid stimulating hormone receptor (TSHR) A-subunit primed animals undergoing Graves' orbitopathy (GO) showed proliferative responses to purified TSHR antigen and secreted proinflammatory cytokines.

  2. Lung fibroblasts of TSHR KO mice have decreased cell surface Igf1r (zeige IGF1R Proteine) expression, and have Igf1r (zeige IGF1R Proteine) protein and protein fragments in both cytoplasm and nucleus. Igf1r (zeige IGF1R Proteine) mRNA levels were similar between TSHR KO and WT mice.

  3. The mechanism, underlying TSH-induced liver triglyceride accumulation, involved that TSH, through its receptor TSHR, triggered hepatic SREBP-1c (zeige SREBF1 Proteine) activity.

  4. These findings suggest that activation of TSHR directly inhibits FASN (zeige FASN Proteine) expression in mature adipocytes, possibly mediated by PKA and ERK (zeige EPHB2 Proteine)

  5. A novel role for TSHR in behavioral and neurological phenotypes of Attention deficit/hyperactivity disorder.

  6. The data indicate functional TSHR is expressed in ventricular myocytes and mediates TSH-induced BNP secretion and HMGCR (zeige HMGCR Proteine) up-regulation through the cAMP/PKA/pCREB signaling pathway.

  7. findings demonstrate TSH-R expression is thymus-specific within the immune system; data support the notion of a novel neuroendocrine-immune interaction in which TSH-R signaling in the thymus, most likely mediated by TSH, enhances thymic T-cell development

  8. The inhibition of hepatic PEPCK (zeige PEPCK Proteine) and G6P and enhanced expression of GK contributed to the development of fasting hypoglycemia in Tshr-ko mice.

  9. UCP-1 (zeige UCP1 Proteine) and TSHR co-localized in retrobulbar adipose tissues in murine models of Graves' disease.

  10. Cloned a thyroid-stimulating hormone receptor (TSHR) cDNA from thyroid glands. The sequence of this cDNA indicated that it encoded a 739 amino acid TSHR splice variant that lacked exon 5 (TSHR739).

Cow (Bovine) Thyroid Stimulating Hormone Receptor (TSHR) Interaktionspartner

  1. Localization of thyrotropin receptor and thyroglobulin (zeige TG Proteine) in the bovine corpus luteum.

  2. analysis of activation switch in the thyrotropin receptor

  3. Rhes (zeige RASD2 Proteine) can interfere with the functional activity of wt and mutated TSHr.

  4. Increased receptor binding by bovine (b) TSH bound to monoclonal antibody to bTSHbeta-subunit.

  5. the hinge region represents an extracellular intermediate connector for both hormone binding and signal transduction of the thyroid stimulating hormone receptor

Horse (Equine) Thyroid Stimulating Hormone Receptor (TSHR) Interaktionspartner

  1. The equine TSHR is not responsive to equine chorionic gonadotropin but is more sensitive to human CG than the human TSHR

TSH receptor (TSHR) Protein Überblick

Protein Überblick

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TSH receptor (TSHR)

  • thyroid stimulating hormone receptor (tshr)
  • thyroid stimulating hormone receptor (TSHR)
  • thyrotropin receptor (TSH-R)
  • thyroid stimulating hormone receptor (Tshr)
  • AI481368 Protein
  • CHNG1 Protein
  • hTSHR-I Protein
  • hypothroid Protein
  • hyt Protein
  • LGR3 Protein
  • pet Protein
  • TSH-R Protein
  • TSHRA Protein

Bezeichner auf Proteinebene für TSHR

TSH receptor , thyroid-stimulating hormone receptor , thyrotropin receptor , seven transmembrane helix receptor , thyrotropin receptor-I, hTSHR-I , TSH-R

560609 Danio rerio
574251 Macaca mulatta
100534416 Oreochromis niloticus
7253 Homo sapiens
397560 Sus scrofa
22095 Mus musculus
25360 Rattus norvegicus
428900 Gallus gallus
403968 Canis lupus familiaris
281553 Bos taurus
100721620 Cavia porcellus
493842 Felis catus
443428 Ovis aries
100052603 Equus caballus
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