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Our findings suggest that variants inside or near TPO (zeige THPO ELISA Kits), ATXN2 (zeige ATXN2 ELISA Kits) and RASGRP1 (zeige RASGRP1 ELISA Kits) genes are associated with HT. Identified loci are novel to HT and represent good basis for further exploration of HT susceptibility.
Our study indicated that the prevalence of TPO (zeige THPO ELISA Kits) mutations was 1% among studied Chinese patients with CH. A novel TPO (zeige THPO ELISA Kits) variation c.1682C>T/p. T561M was found, thereby expanding the mutational spectrum of the gene.
It is concluded that TPO (zeige THPO ELISA Kits) 2173A>C polymorphism may be considered as a risk factor for developing autoimmune thyroiditis in patients with allergic rhinitis and asthma and that these patients should regularly be checked for hidden thyroiditis.
TPO (zeige THPO ELISA Kits) transcripts were present in both normal and breast cancer tissue samples, although the amounts in the latter were reduced. TPO (zeige THPO ELISA Kits) levels are lower in more advanced cancers.
Biallelic TPO (zeige THPO ELISA Kits) mutations most commonly underlie severe congenital hypothyroidism.
The results of the study suggest that rs11675434 SNP located near TPO (zeige THPO ELISA Kits) is associated with the development of Graves ophthalmopathy, especially in males and patients with later age of the disease onset.
Mutations in the TPO (zeige THPO ELISA Kits) gene are associated with Congenital hypothyroidism and thyroid dyshormonogenesis.
Compound heterozygous mutations in the TPO (zeige THPO ELISA Kits) gene are associated with congenital hypothyroidism.
Mutations in the genes for thyroglobulin (zeige TG ELISA Kits) and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability
Studies suggest that Thyroid Peroxidase autoantibodies in early to mid-pregnancy is associated with concurrent depression and may be predictive of depression in the postpartum period.
Lnk (zeige SH2B3 ELISA Kits) Deficiency Leads to TPO (zeige THPO ELISA Kits)-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype
Hearing impairment in hypothyroid dwarf (zeige POU1F1 ELISA Kits) mice caused by mutations of the thyroid peroxidase gene.
Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO (zeige THPO ELISA Kits).
A novel hypothyroid dwarfism is due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
TPO gene was mapped
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
, thyroid peroxidase-like
, thyroid microsomal antigen
, thyroid peroxidase (332 AA)