VAV3 Proteine (VAV3)

Vav 3 Oncogene Proteine (VAV3)
Auf finden Sie aktuell 6 Vav 3 Oncogene (VAV3) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen VAV3 Antikörper (90) und VAV3 Kits (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 112 VAV3 Produkte verfügbar.
A530094I06Rik, AA986410, Idd18.1, RGD1565941
alle Proteine anzeigen Gen GeneID UniProt
VAV3 10451 Q9UKW4
Ratte VAV3 VAV3 295378  
Maus VAV3 VAV3 57257 Q9R0C8

Weitere Synonyme anzeigen

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Weitere Proteine zu VAV3 Interaktionspartnern

Human Vav 3 Oncogene (VAV3) Interaktionspartner

  1. Vav3 is a novel TRAF6 (zeige TRAF6 Proteine) interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.

  2. this study shows that the anti-tumor effects of astragaloside IV are mediated by the downregulation of Vav3-mediated Rac1/MAPK (zeige MAPK1 Proteine) activation

  3. Our results indicated that individuals carrying the VAV3 rs7528153 TT genotype were at a significantly increased risk of developing Paget's Disease of Bone

  4. Vav3 was accumulated in cell protrusions, contributed to the formation of membrane protrusions, and thereby increased the motility and invasiveness of pancreatic ductal adenocarcinoma cells

  5. Vav3 inhibition can suppress cell activity and promote apoptosis by regulating the apoptosis-related genes through the ERK (zeige EPHB2 Proteine) pathway

  6. Data show that microRNA miR (zeige MLXIP Proteine)-499-5p targeted 3' untranslated regions (3'-UTR) of vav 3 oncogene protein (VAV3).

  7. Results found that OSR2, VAV3, and PPFIA3 (zeige PPFIA3 Proteine) were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC.

  8. Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (zeige SYT4 Proteine), BAG3 (zeige BAG3 Proteine), APOA1 (zeige APOA1 Proteine), and VAV3, except for VGF (zeige VGF Proteine) protein, there was a trend between the expression of these four genes and their protein levels.

  9. VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma.

  10. VAV3 overexpression could be a useful marker for predicting the outcomes of CRC (zeige CALR Proteine) patients and that VAV3 targeting represents a potential modality for treating CRC (zeige CALR Proteine)

Mouse (Murine) Vav 3 Oncogene (VAV3) Interaktionspartner

  1. we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.

  2. Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis.

  3. Platelet P-Rex and Vav (zeige VAV1 Proteine) family Rac (zeige AKT1 Proteine)-GEFs play important proinflammatory roles in leukocyte recruitment.

  4. chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin (zeige INS Proteine) state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity

  5. Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 is critical for the development of this tumor type.

  6. Vav2 and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.

  7. Vav3 collaborates with p190 (zeige CNTNAP1 Proteine)-BCR-ABL (zeige ABL1 Proteine) in lymphoid progenitor leukemogenesis, proliferation, and survival.

  8. Dectin-1 (zeige CLEC7A Proteine) activates the integrin Mac-1 (zeige ITGAM Proteine) in neutrophils via Vav1 (zeige VAV1 Proteine) and Vav3 signaling to promote Candida albicans clearance.

  9. study discloses an essential and nonredundant role for this Vav (zeige VAV1 Proteine) family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates

  10. CD36 (zeige CD36 Proteine) contributes to activation of Vav-1 (zeige VAV1 Proteine), -2, and -3 in aortae from hyperlipidemic mice

VAV3 Protein Überblick

Protein Überblick

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with VAV3

  • vav 3 guanine nucleotide exchange factor (VAV3)
  • vav 3 guanine nucleotide exchange factor (Vav3)
  • vav 3 oncogene (Vav3)
  • A530094I06Rik Protein
  • AA986410 Protein
  • Idd18.1 Protein
  • RGD1565941 Protein

Bezeichner auf Proteinebene für Vav 3 Oncogene Proteine (VAV3)

vav 3 oncogene , guanine nucleotide exchange factor VAV3 , VAV-3 , vav 3 protein

100057737 Equus caballus
694685 Macaca mulatta
100220994 Taeniopygia guttata
373939 Gallus gallus
10451 Homo sapiens
479921 Canis lupus familiaris
295378 Rattus norvegicus
521961 Bos taurus
57257 Mus musculus
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