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Data show that GEF Vav1 possesses tumor-suppressor functions in immature T cells.
Polymorphisms of VAV1 gene is associated with Rheumatoid arthritis.
Vav1 expression is increased in esophageal squamous cell carcinoma, indicates poor prognosis, and can serve as a candidate molecular prognostic marker.
TGFbeta (zeige TGFB1 ELISA Kits) induced the dissociation of DNMT1 (zeige DNMT1 ELISA Kits) from the VAV1 promoter, leading to demethylation and the subsequent ectopic expression of VAV1 in cancer cells via a SMAD4 (zeige SMAD4 ELISA Kits)-dependent mechanism
Our results suggest the existence of a Vav1/PU.1/miR (zeige MLXIP ELISA Kits)-142-3p network that supports all-trans retinoic acid -induced differentiation in acute promyelocytic leukemia (zeige PML ELISA Kits) -derived cells
revealed a new function for Vav1 in the negative feedback regulation of the phosphorylation of immunoreceptor tyrosine-based activation motifs within the zeta chains, CD3 delta (zeige CD3D ELISA Kits), epsilon, gamma chains, as well as activation sites on the critical T cell tyrosine kinases
Data indicate that only a single mutation in the proto-oncogene (zeige RAB1A ELISA Kits) Vav1 enhances tumorigenicity.
These findings establish VAV1 as a critical epigenetically regulated oncogene (zeige RAB1A ELISA Kits) with a key role in MBSHH maintenance, and highlight its potential as a validated therapeutic target and prognostic biomarker for the improved therapy of medulloblastoma.
The present study implies that estrogen-estrogen receptor (zeige ESR1 ELISA Kits) modulates the transcription and expression of Vav1, which may contribute to the proliferation of cancerous cells.
The role of Vav1 in T leukemia survival by selectively triggering Rac2 (zeige RAC2 ELISA Kits)-Akt (zeige AKT1 ELISA Kits) axis and elevating the expression of anti-apoptotic Bcl-2 (zeige BCL2 ELISA Kits).
this study reveals a novel function of Vav1 in regulating mesenchymal stem cell fate decisions for differentiation through Sirt1 (zeige SIRT1 ELISA Kits).
Data show that GEF (zeige ARHGEF2 ELISA Kits) Vav1 possesses tumor-suppressor functions in immature T cells.
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 (zeige GRB2 ELISA Kits) stability
Vav1 adaptor has a role in the production of inflammatory cytokines by effector T cells and in the susceptibility to neuroinflammation
provide evidence that CD28 (zeige CD28 ELISA Kits) and the TCR complex regulate NF-kappaB (zeige NFKB1 ELISA Kits) via different signaling modules of GRB-2 (zeige GRB2 ELISA Kits)/VAV1 and LAT (zeige LAT ELISA Kits)/ADAP (zeige APP ELISA Kits) pathways respectively.
Platelet P-Rex and Vav family Rac (zeige AKT1 ELISA Kits)-GEFs play important proinflammatory roles in leukocyte recruitment.
The data show that vav1 not only affects transcription of the MHCII locus but also is an important regulator of MHCII protein transport to the cell surface.
analyses revealed a SHP2 (zeige PTPN11 ELISA Kits)- and Lyn (zeige LYN ELISA Kits)-dependent pathway leading to phosphorylation of Vav1, Rac (zeige AKT1 ELISA Kits) activation, and F-actin polymerization in SCF (zeige KITLG ELISA Kits)-treated BMMCs
Data indicate that Vav1 was a key negative regulator of macrophage-derived IL-6 (zeige IL6 ELISA Kits) production.
Bruton's Tyrosine Kinase (BTK (zeige BTK ELISA Kits)) and Vav1 contribute to Dectin1 (zeige CLEC7A ELISA Kits)-dependent phagocytosis of Candida albicans in macrophages.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
vav 1 oncogene
, proto-oncogene vav
, vav oncogene