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PKCdelta is a critical regulator of signaling mechanisms of neutrophil-endothelium interaction in acute inflammation. Inhibition of PKCdelta in human endothelial cells and neutrophils reduced chemoattractant-induced neutrophil migration across TNF-alpha (zeige TNF Proteine)-activated endothelium, and reduced expression of E-selectin (zeige SELE Proteine) and ICAM-1 (zeige ICAM1 Proteine). Shear rate and vascular geometry regulate the impact of PKCdelta inhibition of neutrophil-endot...
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (zeige HCK Proteine)-dependent activation of PKCdelta, which stimulates PKCgamma (zeige PRKCG Proteine), resulting in translocation of phosphorylated p47(phox).
The interplay between intracellular progesterone receptor (zeige PGR Proteine) and PRKCA (zeige PKCa Proteine)-PRKCD plays a key role in migration and invasion of human glioblastoma cells.
Amphiregulin (zeige AREG Proteine) enhances VEGF-A (zeige VEGFA Proteine) production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR (zeige MLXIP Proteine)-206 via FAK (zeige PTK2 Proteine)/c-Src (zeige SRC Proteine)/PKCdelta pathway.
In the present investigation, we demonstrated that miR486 is negatively associated with the expression of PKC-delta and could regulate the development of osteosarcoma. miR (zeige MLXIP Proteine)-486 may be a potential target for the treatment of osteosarcoma
PKCdelta and PKCepsilon (zeige PRKCE Proteine) work as a functional couple with opposite roles on thrombopoiesis, and the modulation of their balance strongly impacts platelet production.
These findings suggest that targeting Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) or Akt (zeige AKT1 Proteine) pathways may increase the efficacy of taxane chemotherapy in advanced human prostate cancers that have lost PKCdelta expression.
description of a rare monogenic form of juvenile systemic lupus erythematosus caused by a novel but damaging homozygous mutation affecting the active region of PRKCD.
MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2 (zeige SRSF2 Proteine)) to promote alternative splicing of PKCdeltaII.
mechanistic studies, inhibition of SRC (zeige SRC Proteine) and PKCdelta completely ablated the ability of MDA-7/IL-24 (zeige IL24 Proteine) to reduce the Bcl-x(L (zeige BCL2L1 Proteine))/(s) mRNA ratio and cell viability. These findings show that Bcl-x (zeige BCL2L1 Proteine)(s) expression is an important mediator of MDA-7/IL-24 (zeige IL24 Proteine)-induced cytotoxicity requiring the SRC (zeige SRC Proteine)/PKCdelta signaling axis in NSCLC cells.
Data indicate a subpopulation of the CaV1.2 (zeige CACNA1C Proteine) channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (zeige SCP2 Proteine)), a form of synaptic plasticity that requires Cav1.2 (zeige CACNA1C Proteine) and enhancement of its activity by the beta2-adrenergic receptor (zeige ADRB2 Proteine) (beta2AR (zeige ADRB2 Proteine))-cAMP-PKA cascade.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (zeige NRG1 Proteine) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
spinal PKCdelta has a role in the development of chronic pain in SCD (zeige SCD Proteine), which may become a potential target for pharmacological interventions
study identifies a new role of Dual-AKAP1 (zeige AKAP1 Proteine) in regulating mitochondrial trafficking through Miro-2 (zeige RHOT2 Proteine), and supports a model in which PINK1 (zeige PINK1 Proteine) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity
Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)
K8/K18 (zeige KRT18 Proteine)-dependent PKCdelta- and ASMase (zeige SMPD1 Proteine)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (zeige KRT18 Proteine) loss.
cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH (zeige SHH Proteine) signaling through regulation of GLI3 (zeige GLI3 Proteine) processing.
this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor (zeige CSF1R Proteine) DNA methylation (zeige HELLS Proteine) resulting in macrophage maturation
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2 (zeige FGF2 Proteine)) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 (zeige FGF2 Proteine) regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (zeige NOS3 Proteine) post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase (zeige CDK7 Proteine) Cdelta-dependent phosphorylation of syndecan-4 (zeige SDC4 Proteine) regulates cell migration.
Activation of PKC induces the translocation of Nrf2 (zeige NFE2L2 Proteine) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta (zeige PRKCG Proteine) mediates the apoptotic processes through ROS (zeige ROS1 Proteine)-dependent caspase-3 (zeige CASP3 Proteine) activation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta VIII
, protein kinase C delta type
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, PKA C-alpha
, cAMP-dependent protein kinase catalytic subunit alpha
, sperm cAMP-dependent protein kinase catalytic subunit
, protein kinase C delta
, protein kinase C gamma type