IRF4 Proteine (IRF4)

Interferon Regulatory Factor 4 Proteine (IRF4)
Auf finden Sie aktuell 11 Interferon Regulatory Factor 4 (IRF4) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen IRF4 Antikörper (142) und IRF4 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 172 IRF4 Produkte verfügbar.
AI385587, IRF-4, irf4, LSIRF, MUM1, NF-EM5, si:ch73-170d1.2, Spip
alle Proteine anzeigen Gen GeneID UniProt
IRF4 3662 Q15306
IRF4 16364 Q64287
Ratte IRF4 IRF4 291100  

Weitere Synonyme anzeigen

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Weitere Proteine zu IRF4 Interaktionspartnern

Human Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

  1. PU.1-induced apoptosis in myeloma cells is associated with IRF4 downregulation and subsequent IRF7 (zeige IRF7 Proteine) upregulation.

  2. GM-CSF (zeige CSF2 Proteine) can mediate inflammation and pain by regulating IRF4-induced CCL17 (zeige CCL17 Proteine) production

  3. expression of CARMA1 (zeige CARD11 Proteine) mRNA is likely associated with the expression of MUM1 and shows male predominance in diffuse large B cell lymphoma.

  4. Data show that BCL-6 (zeige BCL6 Proteine) (64%) and MUM1 (45%) were expressed in patients with primary mediastinal large B-cell lymphoma.

  5. The study demonstrated differential MUM-1 expression between PEComas and other true melanocytic tumors

  6. Mum-1 was positive in all but one case (96.7%) of systemic anaplastic large-cell lymphoma by tissue microarray immunohistochem analysis.

  7. These results show that MUM1 is a strong and robust predictive immunohistochemical marker in patients with follicular lymphoma

  8. MUM1 expression is reliable in the prognosis of diffuse large B-cell lymphoma.

  9. MUM-1 could be a useful marker for the differential diagnosis of angioimmunoblastic T cell lymphoma (AITL) with Hodgkin/Reed-Sternberg like cells and classical Hodgkins lymphoma.

  10. identify PDL1 (zeige CD274 Proteine) and MUM1 as prognostic biomarkers for high-risk disease in primary mediastinal large B-cell lymphoma

Mouse (Murine) Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

  1. GM-CSF (zeige CSF2 Proteine) can mediate inflammation and pain by regulating IRF4-induced CCL17 (zeige CCL17 Proteine) production

  2. MTORC2 (zeige CRTC2 Proteine) operated in parallel with the IL-4Ralpha-Stat6 (zeige STAT6 Proteine) pathway.

  3. IRF4 mRNA and protein expression was remarkably suppressed during the development of myeloid-derived suppressor cells in the tumor microenvironment. IRF4 expression in MDSCs can modulate their activity to inhibit T cell proliferation through IL-10 (zeige IL10 Proteine) production and ROS (zeige ROS1 Proteine) generation, and myeloid-specific deletion of IRF4 leads to the increase of MDSC differentiation. IRF4 reduction induced by tumors can increase MDSC numbers.

  4. propose that Irf4 is imperative for thymic Treg homeostasis because it regulates thymic epithelial cell-specific expression of several chemokines and costimulatory molecules indicated in thymocyte development and Treg induction

  5. MHC II(+) resident peritoneal and pleural macrophages are continuously replenished by blood monocytes recruited to the peritoneal and pleural cavities constitutively, starting after birth, where they require IRF4 and signals likely derived from the microbiome to fully differentiate.

  6. this study shows that PU.1 functions as a positive regulator of CD11c (zeige ITGAX Proteine) gene expression by directly binding to the Itgax (zeige ITGAX Proteine) promoter and through transactivation of the Irf4 gene

  7. this study shows that the affinity of different enhancers for the BATF-IRF4 complex might underlie divergent signaling outcomes in response to various strengths of TCR signaling

  8. this study shows that baicalin upregulates IRF4 protein expression and alleviates colitis by modulating macrophage polarization to the M2 phenotype

  9. Group 2 innate lymphoid cells utilize the IRF4-IL-9 (zeige IL9 Proteine) module to coordinate epithelial cell maintenance of lung homeostasis.

  10. data reveal that CCR7 (zeige CCR7 Proteine) plays multifaceted roles in regulating collecting vessel permeability and fibrosis, with one of the key players being IRF4-dependent DCs.

Zebrafish Interferon Regulatory Factor 4 (IRF4) Interaktionspartner

  1. IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.

IRF4 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with IRF4

  • interferon regulatory factor 4 (IRF4)
  • Interferon regulatory factor 4 (irf4)
  • interferon regulatory factor 4 (LOC100223845)
  • interferon regulatory factor 4 (Irf4)
  • interferon regulatory factor 4a (irf4a)
  • melanoma associated antigen (mutated) 1 (MUM1)
  • AI385587 Protein
  • IRF-4 Protein
  • irf4 Protein
  • LSIRF Protein
  • MUM1 Protein
  • NF-EM5 Protein
  • si:ch73-170d1.2 Protein
  • Spip Protein

Bezeichner auf Proteinebene für IRF4

interferon regulatory factor 4 , Interferon regulatory factor 4 , lymphocyte-specific interferon regulatory factor , multiple myeloma oncogene 1 , NF-EM5 , PU.1 interaction partner , Sfpi1/PU.1 interaction partner , transcriptional activator PIP , irf4 , MUM-1 , PWWP domain-containing protein MUM1 , mutated melanoma-associated antigen 1

462386 Pan troglodytes
722883 Macaca mulatta
100194953 Salmo salar
100223845 Taeniopygia guttata
100590106 Nomascus leucogenys
3662 Homo sapiens
374179 Gallus gallus
100144625 Sus scrofa
16364 Mus musculus
291100 Rattus norvegicus
100002070 Danio rerio
612320 Canis lupus familiaris
513471 Bos taurus
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