CD4 Proteine (CD4)

Bezeichnung:
CD4 Molecule Proteine (CD4)
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Synonyme:
cd4, CD4mut, L3T4, Ly-4, p55, W3/25
alle Proteine anzeigen Gen GeneID UniProt
CD4 12504 P06332
CD4 920 P01730
CD4 24932 P05540

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Am meisten referenzierte CD4 Proteine

  1. Human CD4 Protein expressed in HEK-293 Cells - ABIN2180791 : Crise, Buonocore, Rose: CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor. in Journal of virology 1990 (PubMed)
    Zeige alle 3 Referenzen für 2180791

  2. Mouse (Murine) CD4 Protein expressed in Human Cells - ABIN2007381 : Ryu, Truneh, Sweet, Hendrickson: Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. in Structure (London, England : 1993) 1994 (PubMed)
    Zeige alle 2 Referenzen für 2007381

  3. Rhesus Monkey CD4 Protein expressed in HEK-293 Cells - ABIN2180784 : Rudd, Trevillyan, Dasgupta, Wong, Schlossman: Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)

Weitere Proteine zu CD4 Interaktionspartnern

Mouse (Murine) CD4 Molecule (CD4) Interaktionspartner

  1. results suggest that CD4 CD8 (zeige CD8A Proteine) double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT (zeige NT5C Proteine) cells

  2. TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.

  3. High-fat diet - induced type 2 diabetes decreases the number of ileum IL17 (zeige IL17A Proteine)/RORgammaT CD4 T cells.

  4. Results indicate that hypomethylation of Cd4 antigen correlates with stable CD4 expression.

  5. CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase (zeige YES1 Proteine) p56lck (zeige LCK Proteine)

  6. This study establishes an important role of IgE in abdominal aortic aneurysms pathogenesis by activating CD4+ T cells, mast cells, and macrophages.

  7. 5-kb cis (zeige CISH Proteine)-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis (zeige CISH Proteine)-element by DNA methylation (zeige HELLS Proteine)

  8. Both type I CD8 (zeige CD8A Proteine)+ cytotoxic (Tc1 (zeige C8orf4 Proteine)) cells and interleukin (IL)-17 (zeige IL17A Proteine)-producing CD8 (zeige CD8A Proteine)+ (Tc17) cells mediate effective antitumor immunity through distinct effector mechanisms, but Tc1 (zeige C8orf4 Proteine) cells are superior to Tc17 cells in mediating tumor regression.

  9. Accumulation of CD4 positive effector T cells is a critical step in the progression from mild glomerulonephritis to severe crescentic glomerulonephritis accompanied by tubulointerstitial inflammation and loss of kidney function.

  10. Thymic selection does not appear to play an important role in CD4+CD8+ T cell receptor (TCR)beta repertoire overlap between individuals.

Human CD4 Molecule (CD4) Interaktionspartner

  1. We investigated the prevalence, magnitude and phenotype of CTAg (zeige CTAG1B Proteine)-specific T cells in the blood of patients with testicular germ cell tumors (TGCTs). CD8 (zeige CD8A Proteine)(+) and CD4(+) T-cell responses against MAGE (zeige MAGEB10 Proteine)-A family antigens were present in 44% (20/45) of patients' samples assayed by ex vivo IFN-gamma (zeige IFNG Proteine) ELISPOT. Spontaneous T-cell immunity against CTAg (zeige CTAG1B Proteine) proteins therefore develops in many patients with testicular cancer.

  2. Depletion of the gamma2 or mu1A (AP1M1 (zeige AP1M1 Proteine)) subunits of AP-1 (zeige FOSB Proteine), but not of gamma1 (AP1G1 (zeige AP1G1 Proteine)), precludes Nef-mediated lysosomal degradation of CD4.

  3. findings provide a mechanistic explanation for previous observations that dimerization-defective Nef mutants fail to down-regulate CD4 and validate the Nef dimerization interface as a target site for antiretroviral drug development

  4. Mouse leukemia cell lines that could express hCD4 and CCR5 were thus established to facilitate normal entry of HIV-1 so that a human CD4/CCR5 transgenic mice cell model can be used to investigate the transmission and pathogenesis of HIV/AIDS and potential antiviral drugs against this disease.

  5. The percentage of lamina propia CD4+LAP+ cells is increased in active ulcerative colitis, showing reduced suppressor activity due to their increased proportion of intracellular IL-17 (zeige IL17A Proteine) expression.

  6. The study gives insights into the role of CD4 on cell membrane mechanical characteristics.

  7. A decrease of CD4(+) CD25 (zeige IL2RA Proteine)(+) CD127 (zeige IL7R Proteine)(low) FoxP3 (zeige FOXP3 Proteine)(+) regulatory T cells with impaired suppressive function had been found in untreated ulcerative colitis patients.

  8. Redox shuffling of the allosteric disulfide results in previously undescribed conformational changes in CD4 that are likely important for its interaction with its protein partners.

  9. Increased levels of activated and highly susceptible HIV-1 target cells, reduced CD4 and enhanced CXCR4 (zeige CXCR4 Proteine) cell surface expression, together with the high susceptibility to FAS (zeige FAS Proteine)-induced programmed cell death may contribute to the rapid CD4+ T cell depletion.

  10. HRB (zeige HRB Proteine) knock-down affected CD4 downregulation induced by Nef but not by HIV-1 Vpu.

Pig (Porcine) CD4 Molecule (CD4) Interaktionspartner

  1. The frequency and expression of a CD4 variant in microminipigs are described.

  2. These data help clarify the regulatory mechanism of DNA methylation (zeige HELLS Proteine) of the CD4 gene in non-immune cell response to virus replication.

Cow (Bovine) CD4 Molecule (CD4) Interaktionspartner

  1. These results suggest that CD4 plays a role in production traits as well as in immune function. The identified SNPs could be used as genetic markers for selection of dairy cows with improved fat percentage. We propose further studies of these SNPs in a larger population as well as further investigations of the function of this gene.

  2. These results suggested that the SNPs in CD4 and STAT5b (zeige STAT5B Proteine) may be potential genetic markers for SCS (zeige TWIST1 Proteine) and milk/protein (zeige CSN2 Proteine) yields selecting and warrant further functional research.

  3. The DNA methylation (zeige HELLS Proteine) level of the CD4 gene was strongly influenced by mastitis in Chinese Holstein cattle.

  4. These findings revealed that despite the existence of a distinct bovine CD4(+)CD25 (zeige IL2RA Proteine)(high) T cell population, which showed Foxp3 (zeige FOXP3 Proteine) transcription/expression, natural regulatory activity did not reside in this cell population

Rhesus Monkey CD4 Molecule (CD4) Interaktionspartner

  1. The absence of CD4 T cells results in failure to produce antibodies that neutralize CD4-independent SIV Envs and CD4-pretriggered control SIV Envs.

Chimpanzee CD4 Molecule (CD4) Interaktionspartner

  1. study found noticeable variation in the first variable region V1 of CD4 and in intron six among the subspecies of chimpanzees.

CD4 Protein Überblick

Protein Überblick

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Alternative names and synonyms associated with CD4

  • CD4 molecule (CD4)
  • CD4 antigen (cd4)
  • T-cell surface glycoprotein CD4 (cd4)
  • CD4 antigen (Cd4)
  • Cd4 molecule (Cd4)
  • CD4 molecule (Cd4)
  • cd4 Protein
  • CD4mut Protein
  • L3T4 Protein
  • Ly-4 Protein
  • p55 Protein
  • W3/25 Protein

Bezeichner auf Proteinebene für CD4 Molecule Proteine (CD4)

CD4 antigen , T-cell surface glycoprotein CD4 , T-cell differentiation antigen L3T4 , T-cell surface antigen T4/Leu-3 , T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4) , CD4 antigen (p55) , CD4 receptor , W3/25 antigen , lymphocyte antigen CD4 , cell surface glycoprotein CD4

GENE ID SPEZIES
100016045 Monodelphis domestica
100125525 Oryzias latipes
778001 Takifugu rubripes
100286469 Salmo salar
12504 Mus musculus
920 Homo sapiens
24932 Rattus norvegicus
101790140 Anas platyrhynchos
493775 Felis catus
404704 Sus scrofa
395362 Gallus gallus
403931 Canis lupus familiaris
443509 Ovis aries
407098 Bos taurus
100734494 Cavia porcellus
100009152 Oryctolagus cuniculus
100126554 Meleagris gallopavo
713807 Macaca mulatta
450124 Pan troglodytes
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