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RNA knockdown of Syt-7 in human islets reduced first- and second-phase glucose-stimulated insulin (zeige INS Proteine) secretion attributed to the reduction of exocytosis of predocked and newcomer insulin (zeige INS Proteine) secretory granules
Data indicate that small protein sequence changes in the Ca(2 (zeige CA2 Proteine)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 (zeige SYT1 Proteine) and Syt-7 isoforms.
the results suggest that the two C2 domains of Syt7 bind independently to planar membranes, in contrast to reported interdomain cooperativity in Syt1 (zeige SYT1 Proteine)
The membrane dissociation of SYT7 C2A domain but not SYT1 C2A domain is slowed by Na(2)SO(4) and trehalose, solutes that enhance the hydrophobic effect.
identified the conserved alternative splicing events in the spacer domain of Syt VII; also shown that Syt (zeige SS18 Proteine) VIIa-GFP is mainly localized in the perinuclear region and tips of neurites (dense-core vesicles), and not in the plasma membrane
At the calyx synapse that syt7-dependent asynchronous release indeed does not produce a prolonged synaptic signal after a stimulus train and does not contribute to short-term plasticity, but induces a steady-state, asynchronous postsynaptic current during stimulus trains. This steady-state postsynaptic current sustains reliable generation of postsynaptic spikes that are precisely time locked to presynaptic spikes.
results suggest that postsynaptic Syt1 (zeige SYT1 Proteine) and Syt7 act as redundant Ca(2 (zeige CA2 Proteine)+)-sensors for Ca(2 (zeige CA2 Proteine)+)-dependent exocytosis of AMPA (zeige GRIA3 Proteine) receptors during long-term potentiation, and thereby delineate a simple mechanism for the recruitment of AMPA (zeige GRIA3 Proteine) receptors that mediates LTP (zeige SCP2 Proteine)
Data (including data from studies in knockout mice) suggest that loss of both Syt1 (zeige SYT1 Proteine)/Syt7 decreases capacity of readily-releasable pool (RRP (zeige RRBP1 Proteine)) of Ca2 (zeige CA2 Proteine)+ in synaptic vesicles without altering rate of priming into RRP (zeige RRBP1 Proteine); Syt1 (zeige SYT1 Proteine)/Syt7 functions appear redundant.
synaptotagmin 7 (Syt7) is a calcium sensor that is required for facilitation at several central synapses
Use of neurons from double-knock-out (SNAP-25 (zeige SNAP25 Proteine), synaptotagmin-7) mice in combination with viral transduction showed that SNAP-23 (zeige SNAP23 Proteine)-driven release is triggered by endogenous synaptotagmin-7
Complex of syt 7 and calmodulin (zeige Calm2 Proteine) serves as a key regulator of synaptic vesicle replenishment in presynaptic nerve terminals.
synaptotagmin-7 is directly activated by GLP-1 (zeige GCG Proteine) signaling and may serve as a drug target for boosting insulin (zeige INS Proteine) secretion.
knock-out of synaptotagmin-7 selectively impaired delayed asynchronous neurotransmitter release but not synchronous release. In contrast, the readily releasable vesicles after depletion recover normally in knock-out mice.
Ca(2 (zeige CA2 Proteine)+)-triggered release at a synapse is due to synaptotagmins, with synaptotagmin-7 mediating a slower form of Ca(2 (zeige CA2 Proteine)+)-triggered release that is normally occluded by faster synaptotagmin-1 (zeige SYT1 Proteine)-induced release but becomes manifest upon synaptotagmin-1 (zeige SYT1 Proteine) deletion
Results demonstrate that synaptotagmin-7 functions as a positive regulator of GLP-1 (zeige GCG Proteine) secretion in intestinal L-cells and GLUTag cells, consistent with its proposed role as a calcium sensor in GLP-1 (zeige GCG Proteine) secretion.
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, synaptotagmin VII
, synaptotagmin 7
, prostate cancer-associated protein 7