Synaptotagmin II Proteine (SYT2)

Bezeichnung:
Synaptotagmin II Proteine (SYT2)
Auf www.antikoerper-online.de finden Sie aktuell 7 Synaptotagmin II (SYT2) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Synaptotagmin II Antikörper (77) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 89 Synaptotagmin II Produkte verfügbar.
Synonyme:
mKIAA4194, R74640, RATSYNII, si:ch211-236j4.1, SYNII, SytII
alle Proteine anzeigen Gen GeneID UniProt
SYT2 127833 Q8N9I0
SYT2 20980 P46097
SYT2 24805 P29101

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Weitere Proteine zu Synaptotagmin II Interaktionspartnern

Zebrafish Synaptotagmin II (SYT2) Interaktionspartner

  1. knockdown of synaptotagmin 2 (syt2) reduces synchronous release, whereas knockdown of synaptotagmin 7 (syt7 (zeige SYT7 Proteine)) reduces the asynchronous component of release.

Human Synaptotagmin II (SYT2) Interaktionspartner

  1. the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (zeige CA2 Proteine)+)-regulated tethers to the Pplasma membrane.

  2. SYT2 mutations cause a novel complex presynaptic congenital myasthenic syndrome characterized by motor neuropathy causing lower limb wasting and foot deformities, reflex potentiation following exercise and a prolonged period of posttetanic potentiation

  3. Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy.

  4. Human SytII is not an effective receptor for Botulinum neurotoxin D-C.

  5. synaptotagmin-II is not a high affinity receptor for BoNT/B and G due to a phenylalanine to leucine mutation in its luminal domain present only in humans and chimpanzees

  6. role for synaptotagmin II as calcium-sensor during phagocytosis and secretion in neutrophils

  7. both synaptotagmins I and II can interact with the syntaxin/synaptosomal-associated protein of 25 kDa (SNAP-25 (zeige SNAP25 Proteine)) dimer

  8. WNK1 (zeige WNK1 Proteine) selectively binds to and phosphorylates synaptotagmin 2 (Syt2) within its calcium binding C2 domains. Endogenous WNK1 (zeige WNK1 Proteine) and Syt2 coimmunoprecipitate and colocalize on a subset of secretory granules in INS-1 (zeige FOXM1 Proteine) cells.

  9. A recombinant fragment from the luminal domain of the human receptor protein syt (zeige SS18 Proteine) II can bind specifically to botulinum neurotoxin B and its Hc domain.

  10. Mutation of overexpressed Syt2 transgene leaves intrinsic calcium sensitivity of vesicles intact while it destabilizes the readily releasable pool of vesicles and loosens the tight coupling between calcium influx and release.

Mouse (Murine) Synaptotagmin II (SYT2) Interaktionspartner

  1. we identify Syt2 as a functionally important Ca(2 (zeige CA2 Proteine)+) sensor at fast-releasing inhibitory synapses, and show that Syt1 (zeige SYT1 Proteine) and Syt2 can redundantly control transmitter release at specific brain synapses

  2. demonstrates a developmental Syt1 (zeige SYT1 Proteine)-Syt2 isoform switch at an identified synapse, a mechanism that could fine-tune the speed, reliability, and plasticity of transmitter release at fast releasing CNS synapses.

  3. the combined inactivation of all 3 E-Syt (zeige SS18 Proteine) genes has no effect on mouse viability or fertility.

  4. The 2.3-A structure of a ternary complex of botulinum neurotoxin type B bound to both its protein receptor synaptotagmin II and its ganglioside receptor GD1a, is reported.

  5. Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesis

  6. Syt2 make it an excellent marker for analyzing the development and plasticity of perisomatic inhibitory innervations onto both excitatory and inhibitory neurons in the visual cortex.

  7. Syt2 increases the dynamic range of synapses by driving release with a high Ca(2 (zeige CA2 Proteine))+ cooperativity, as well as by suppressing a remaining, near-linear Ca(2 (zeige CA2 Proteine))+ sensor.

  8. Transient expression of Syt2 is no longer detected in cochlear inner hair cells (IHCs) after the onset of hearing, indicating that the most common calcium-sensors in central nervous system synapses are not involved in mature IHC ribbon synapse.

  9. SYT2 was a negative regulator of chemotaxis

  10. The readily releasable pool was rescued by Syt2 overexpression. The kinetics of fusion was slightly slower than in cells expressing Syt1. Syt2 has a lower Ca2+ affinity for phospholipid binding than Syt1 because of a difference in the C2A domain.

Synaptotagmin II (SYT2) Protein Überblick

Protein Überblick

Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994

Alternative names and synonyms associated with Synaptotagmin II (SYT2)

  • synaptotagmin-2-like (LOC100146749)
  • synaptotagmin IIa (syt2a)
  • synaptotagmin II (syt2)
  • synaptotagmin II (SYT2)
  • synaptotagmin II (Syt2)
  • synaptotagmin-like 2 (SYTL2)
  • mKIAA4194 Protein
  • R74640 Protein
  • RATSYNII Protein
  • si:ch211-236j4.1 Protein
  • SYNII Protein
  • SytII Protein

Bezeichner auf Proteinebene für Synaptotagmin II Proteine (SYT2)

synaptotagmin II , synaptotagmin 2 , synaptotagmin-2 , sytII

GENE ID SPEZIES
100146749 Equus caballus
567877 Danio rerio
100158469 Xenopus (Silurana) tropicalis
100511582 Sus scrofa
100594116 Nomascus leucogenys
127833 Homo sapiens
20980 Mus musculus
24805 Rattus norvegicus
100300626 Bos taurus
396327 Gallus gallus
485154 Canis lupus familiaris
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