SYT1 Proteine (SYT1)

Synaptotagmin I Proteine (SYT1)
Auf finden Sie aktuell 19 Synaptotagmin I (SYT1) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SYT1 Antikörper (220) und SYT1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 256 SYT1 Produkte verfügbar.
5430411C10Rik, AW124717, CG3139, D. Syt I, DKFZP459P193, Dmel\\CG3139, Droso1, DSypt, dSYT, dsyt1, Dsyt2, dsytI, G630098F17Rik, GB20036, GOLPH5, GRASP65, l(2)23AB1, l(2)23Ba, l(2)k05909, p65, SVP65, syt, syt-1, syt 1, syt1, syt I, Syti
alle Proteine anzeigen Gen GeneID UniProt
SYT1 74498 Q91X51
SYT1 6857 P21579
SYT1 25716 P21707

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Am meisten referenzierte SYT1 Proteine

  1. Human SYT1 Protein expressed in Escherichia coli (E. coli) - ABIN667472 : Xi, Chin, Gainer: Analysis of synaptotagmin I-IV messenger RNA expression and developmental regulation in the rat hypothalamus and pituitary. in Neuroscience 1999 (PubMed)
    Zeige alle 2 Referenzen für 667472

  2. Human SYT1 Protein expressed in Wheat germ - ABIN1322010 : Liu, Akle, Zheng, Dave, Tortella, Hayes, Wang: Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis. in The Biochemical journal 2006 (PubMed)

Weitere Proteine zu SYT1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Synaptotagmin I (SYT1) Interaktionspartner

  1. tethering of Syt1 to synaptic vesicles in vivo is a prerequisite for its role in facilitating fast synchronous synaptic vesicle release and suppressing asynchronous and spontaneous fusion

  2. synaptic transmission can be regulated by Syt1 multimerization and that both C2 domains of Syt1 are uniquely required for modulating Ca(2 (zeige CA2 Proteine)+)-independent spontaneous fusion and Ca(2 (zeige CA2 Proteine)+)-dependent synchronous release.

  3. effect of APP (zeige APP Proteine) gene on synaptotagmin 1 mRNA level

  4. The major function of Ca2+ binding to synaptotagmin's C2A domain is to neutralize the negative charge of the pocket, thereby unleashing the fusion-stimulating activity of synaptotagmin.

  5. this study provided direct support for the hypothesis that plasma membrane penetration, specifically by the C(2)B domain of synaptotagmin, is the critical effector interaction for coupling Ca(2 (zeige CA2 Proteine)+) binding with vesicle fusion

  6. Results suggest that the tandem C2 domains of Syt 1 play independent roles in neurotransmission.

  7. The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo

  8. Synaptotagmins I and IV promote transmitter release independently of Ca(2 (zeige CA2 Proteine)+) binding in the C(2)A domain

  9. Data show that synaptotagmin I is required for a post-docking step during vesicle fusion but does not function to stabilize the docked vesicle state.

  10. These results indicate that synaptotagmin is the major Ca(2 (zeige CA2 Proteine)+) sensor for evoked release and functions to trigger synchronous fusion in response to Ca(2 (zeige CA2 Proteine)+), while suppressing asynchronous release.

Mouse (Murine) Synaptotagmin I (SYT1) Interaktionspartner

  1. we identify Syt2 (zeige SYT2 Proteine) as a functionally important Ca(2 (zeige CA2 Proteine)+) sensor at fast-releasing inhibitory synapses, and show that Syt1 and Syt2 (zeige SYT2 Proteine) can redundantly control transmitter release at specific brain synapses

  2. results suggest that postsynaptic Syt1 and Syt7 (zeige SYT7 Proteine) act as redundant Ca(2 (zeige CA2 Proteine)+)-sensors for Ca(2 (zeige CA2 Proteine)+)-dependent exocytosis of AMPA (zeige GRIA3 Proteine) receptors during long-term potentiation, and thereby delineate a simple mechanism for the recruitment of AMPA (zeige GRIA3 Proteine) receptors that mediates LTP (zeige SCP2 Proteine)

  3. demonstrates a developmental Syt1-Syt2 (zeige SYT2 Proteine) isoform switch at an identified synapse, a mechanism that could fine-tune the speed, reliability, and plasticity of transmitter release at fast releasing CNS synapses.

  4. the combined inactivation of all 3 E-Syt (zeige SS18 Proteine) genes has no effect on mouse viability or fertility.

  5. GRASP65 (zeige GORASP1 Proteine) phosphorylation may have a critical role in inducing cell death.

  6. We conclude that synaptotagmin-1 phosphorylation is an essential step in PKC-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC substrates, Munc13-1 and Munc18-1 (zeige STXBP1 Proteine).

  7. data show that hepatic Syt1 expression is influenced by diet and hormonal milieu

  8. different structural states of syt (zeige SS18 Proteine) underlie the control of distinct forms of synaptic transmission.

  9. The interaction of Dvl1 (zeige DVL1 Proteine) with Syt-1, which is regulated by Wnts, modulates neurotransmitter release.

  10. Data (including data from studies in knockout mice) suggest that loss of both Syt1/Syt7 (zeige SYT7 Proteine) decreases capacity of readily-releasable pool (RRP (zeige RRBP1 Proteine)) of Ca2 (zeige CA2 Proteine)+ in synaptic vesicles without altering rate of priming into RRP (zeige RRBP1 Proteine); Syt1/Syt7 (zeige SYT7 Proteine) functions appear redundant.

Human Synaptotagmin I (SYT1) Interaktionspartner

  1. SYT (zeige SS18 Proteine)-SSX (zeige SSX2 Proteine) fusion is associated with synovial sarcoma.

  2. the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (zeige CA2 Proteine)+)-regulated tethers to the Pplasma membrane.

  3. Data indicate that small protein sequence changes in the Ca(2 (zeige CA2 Proteine)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 and Syt-7 (zeige SYT7 Proteine) isoforms.

  4. These findings identify Syt1 as a novel Ca(2 (zeige CA2 Proteine)+)-sensitive PS1 (zeige PSEN1 Proteine) modulator that could regulate synaptic ABETA (zeige APP Proteine), opening avenues for novel and selective synapse targeting therapeutic strategies.

  5. One-Step reverse transcriptase real time PCR for the detection SYT (zeige SS18 Proteine)-SSX (zeige SSX2 Proteine) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.

  6. membrane tethering by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (zeige CA2 Proteine)+).

  7. A dominant negative de novo SYT1 missense variant(I368T)altered the kinetics of synaptic vesicle endocytosis and caused an early onset dyskinetic movement disorder, severe motor delay, and profound cognitive impairment.

  8. Data suggest that calcium-dependent phosphatidylinositol 4,5-diphosphate- (PI(4,5)P2-) binding proteins (such as SYT1, PRKCA (zeige PKCa Proteine) [protein kinase C alpha (zeige PKCa Proteine)], and ANXA2 (zeige ANXA2 Proteine) [annexin A2 (zeige ANXA2 Proteine)]) interactions with membrane microdomains are tightly regulated. [REVIEW]

  9. Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 (zeige DDR2 Proteine) rearrangements.

  10. Hydrophobic interactions play a key role in Syt1 binding botulinum neurotoxin DC.

Cow (Bovine) Synaptotagmin I (SYT1) Interaktionspartner

SYT1 Protein Überblick

Protein Überblick

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001

Alternative names and synonyms associated with SYT1

  • Synaptotagmin 1 (Syt1)
  • synaptotagmin I (Syti)
  • synaptotagmin I (SYT1)
  • synaptotagmin-1 (Tsp_06980)
  • synaptotagmin-1 (Tsp_08220)
  • synaptotagmin 1 (syt1)
  • DKFZP459P193 protein (DKFZP459P193)
  • golgi reassembly stacking protein 1 (Gorasp1)
  • synaptotagmin I (Syt1)
  • synaptotagmin VIII (syt8)
  • synaptotagmin VIII (SYT8)
  • synaptotagmin-like 1 (SYTL1)
  • synaptotagmin, p65 (LOC100533340)
  • 5430411C10Rik Protein
  • AW124717 Protein
  • CG3139 Protein
  • D. Syt I Protein
  • DKFZP459P193 Protein
  • Dmel\\CG3139 Protein
  • Droso1 Protein
  • DSypt Protein
  • dSYT Protein
  • dsyt1 Protein
  • Dsyt2 Protein
  • dsytI Protein
  • G630098F17Rik Protein
  • GB20036 Protein
  • GOLPH5 Protein
  • GRASP65 Protein
  • l(2)23AB1 Protein
  • l(2)23Ba Protein
  • l(2)k05909 Protein
  • p65 Protein
  • SVP65 Protein
  • syt Protein
  • syt-1 Protein
  • syt 1 Protein
  • syt1 Protein
  • syt I Protein
  • Syti Protein

Bezeichner auf Proteinebene für Synaptotagmin I Proteine (SYT1)

CG3139-PA , CG3139-PB , CG3139-PC , CG3139-PE , CG3139-PF , CG3139-PG , Synaptotagmin-1 , Synaptotagmin-I , Synaptotagmin1 , SynaptotagminI , Syt1-PA , Syt1-PB , Syt1-PC , Syt1-PE , Syt1-PF , Syt1-PG , synaptoptagmin 1 , synaptotagmin , synaptotagmin 1 , synaptotagmin I , synaptotagmin-1 , DKFZP459P193 protein , Synaptotagmin I , Golgi reassembly-stacking protein 1 , golgi peripheral membrane protein p65 , golgi reassembly-stacking protein of 65 kDa , sytI , p65 , synaptotagmin p65 , synaptotagmin 8 , synaptotagmin I VQ/C2B-beta

33473 Drosophila melanogaster
408613 Apis mellifera
657877 Tribolium castaneum
751605 Taeniopygia guttata
10903271 Trichinella spiralis
10906784 Trichinella spiralis
100037879 Xenopus (Silurana) tropicalis
100189845 Pongo abelii
74498 Mus musculus
6857 Homo sapiens
20979 Mus musculus
25716 Rattus norvegicus
482579 Canis lupus familiaris
281511 Bos taurus
396083 Gallus gallus
100513599 Sus scrofa
100174463 Pongo abelii
695390 Macaca mulatta
570237 Danio rerio
423095 Gallus gallus
487346 Canis lupus familiaris
100511935 Sus scrofa
527641 Bos taurus
100533340 Aplysia californica
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